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Addressing Factors that Impact Sexual Well-Being and Intimacy in IBD Patients
Publication Year: 2025 Source: Curr Gastroenterol Rep PMID: 39779620 DOI: 10.1007/s11894-024-00956-2
PURPOSE OF REVIEW: This review details the pathophysiologic mechanisms from medical, surgical to psychosocial factors that illustrate how and why sexual health and intimacy are impacted in IBD. RECENT FINDINGS: Recent clinical surveys of practicing gastroenterologists document that clinicians should routinely address sexual health when addressing patient reported outcomes but …
Erythema nodosum, malignant melanoma and non-melanoma skin cancer in relation to inflammatory bowel disease: a Mendelian randomization study
Publication Year: 2025 Source: Sci Rep PMID: 39779820 DOI: 10.1038/s41598-025-85249-y
Inflammatory bowel disease (IBD) is a multisystem condition that could affect the cutaneous systems, namely cutaneous extraintestinal manifestations (EIMs). It has been suggested that IBD is associated with erythema nodosum (EN), malignant melanoma (MM) and non-melanoma skin cancer (NMSC). However, the potential causal relationship between IBD and the mentioned above …
Association between allergic diseases and mucosal healing in ulcerative colitis
Publication Year: 2025 Source: Sci Rep PMID: 39779831
Allergic diseases and ulcerative colitis (UC) share pathophysiological similarities. This study aimed to investigate the unclear association between allergic diseases and mucosal healing (MH), an important factor in the prognosis of UC. We studied 289 Japanese patients with UC. Information on allergic diseases (bronchial asthma, atopic dermatitis, pollen allergy, food …
Host metabolism balances microbial regulation of bile acid signalling
Publication Year: 2025 Source: Nature PMID: 39779854
Metabolites derived from the intestinal microbiota, including bile acids (BA), extensively modulate vertebrate physiology, including development(1), metabolism(2-4), immune responses(5-7) and cognitive function(8). However, to what extent host responses balance the physiological effects of microbiota-derived metabolites remains unclear(9,10). Here, using untargeted metabolomics of mouse tissues, we identified a family of BA-methylcysteamine …
Genomic characterization of Escherichia coli with a polyketide synthase (pks) island isolated from ulcerative colitis patients
Publication Year: 2025 Source: BMC Genomics PMID: 39780077
The E. coli strains harboring the polyketide synthase (pks) island encode the genotoxin colibactin, a secondary metabolite reported to have severe implications for human health and for the progression of colorectal cancer. The present study involves whole-genome-wide comparison and phylogenetic analysis of pks harboring E. coli isolates to gain insight …
Developing and evaluating a gamified self-management application for inflammatory bowel disease using the ADDIE model and Sukr framework
Publication Year: 2025 Source: BMC Med Inform Decis Mak PMID: 39780171 DOI: 10.1186/s12911-024-02842-3
BACKGROUND: The prevalence and chronic nature of Inflammatory Bowel Diseases (IBD) is a significant global concern. As the essential part of treatments approach, patient adherence to treatment protocols and self-management practices are crucial to = IBD management. Healthcare initiatives focused on chronic conditions are strongly needed to consider various aspects …
Infliximab-induced symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) in a patient with ulcerative colitis
Publication Year: 2025 Source: Br J Clin Pharmacol PMID: 39780340
Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is a rare, symmetrical skin eruption triggered by various medications, predominantly beta-lactam antibiotics. We report the case of a 69-year-old male with moderate-to-severe ulcerative colitis who developed SDRIFE following the seventh intravenous administration of infliximab. The patient presented with symmetrical, pruritic erythema in …
Phenotype-Led Identification of IL-10 Upregulators in Human CD4(+) T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors
Publication Year: 2025 Source: J Med Chem PMID: 39780505 DOI: 10.1021/acs.jmedchem.4c02630
Therapeutics promoting the endogenous production of IL-10 have the potential to restore homeostasis in inflammatory disorders such as inflammatory bowel disease (IBD). Here we describe the identification of a series of IL-10 upregulators based on a pyrimidyl-piperidine scaffold through a high throughput phenotypic CD4(+) T-cell multiplex assay. In vitro optimization …
New Intestinal Ultrasound Score for Assessing Inflammatory Bowel Disease Activity and Identifying Severity
Publication Year: 2025 Source: J Clin Ultrasound PMID: 39780687 DOI: 10.1002/jcu.23916
PURPOSE: The purpose of this study is to propose new ultrasound scores to assess inflammatory bowel disease (IBD) activity and to analyze their accuracy in assessing disease severity. In addition to this, to validate that intestinal ultrasound can be used as a follow-up tool for the assessment of IBD. METHODS: …
Hemorrhagic Shock Presenting as the First Manifestation of Inflammatory Stricturing Crohn's Disease
Publication Year: 2025 Source: ACG Case Rep J PMID: 39781181 DOI: 10.14309/crj.0000000000001589
While hematochezia is common in Crohn's disease (CD), severe gastrointestinal hemorrhage causing hemodynamic instability is rare. Strictures, another frequent complication, usually cause obstructive symptoms. We report the first case of hemorrhagic shock from ulcerated ileal strictures as the initial presentation of CD. Standard endoscopy and abdominal imaging did not identify …
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