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Acanthoside B attenuates NLRP3-mediated pyroptosis and ulcerative colitis through inhibition of tAGE/RAGE pathway
Publication Year: 2025 Source: Allergol Immunopathol (Madr) PMID: 39786883
Acanthoside B (Aca.B), a principal bioactive compound extracted from Pogostemon cablin, exhibits superior anti-inflammatory capacity. Ulcerative colitis is a nonspecific inflammatory bowel disease with unknown etiology. The potential of Aca.B as a therapeutic agent for ulcerative colitis is also unknown and remains an area for future investigation. In this study, …
Deconditioning in quiescent Crohn's disease patients with heightened fatigue perception
Publication Year: 2025 Source: J Crohns Colitis PMID: 39787044 DOI: 10.1093/ecco-jcc/jjae194
BACKGROUND AND OBJECTIVE: Inflammatory bowel disease (IBD) fatigue aetiology is poorly understood. This study quantified body composition and physical function alongside proton magnetic resonance imaging (1H MRI) and spectroscopy (31P MRS) measures of organ structure and function in quiescent Crohn's disease patients (CD) and healthy volunteers (HVs), to identify a …
Development and validation of an algorithm to better identify pregnant women with inherited bleeding disorders within electronic health records
Publication Year: 2025 Source: Thromb Res PMID: 39787817 DOI: 10.1016/j.thromres.2025.109253
BACKGROUND: When using electronic health records (EHRs) to conduct population-based studies on inherited bleeding disorders (IBDs), using diagnosis codes alone results in a high number of false positive identifications. OBJECTIVE: The objective of this study was to develop and validate an algorithm that uses multiple data elements of EHRs to …
Ribosomal proteins mediate non-canonical regulation of gut inflammatory signature by crop contaminant deoxynivalenol
Publication Year: 2025 Source: Ecotoxicol Environ Saf PMID: 39788032 DOI: 10.1016/j.ecoenv.2024.117645
Deoxynivalenol (DON), a prevalent mycotoxin produced by Fusarium species, contaminates global agricultural products and poses significant health risks, particularly to the gastrointestinal (GI) system. DON exposure disrupts ribosomal function, inducing stress responses linked to various inflammatory diseases, including inflammatory bowel disease (IBD). In this study, we elucidate a novel regulatory …
Linking E. coli to fibrosis in Crohn's disease
Publication Year: 2025 Source: Cell Host Microbe PMID: 39788093
Intestinal fibrosis associated with Crohn's disease is a serious yet poorly understood clinical complication. In this issue of Cell Host & Microbe, Ahn and colleagues provide evidence that the adherent intestinal E. coli produced the metallophore yersiniabactin, which sequesters zinc to drive intestinal fibrosis in a HIF-1alpha-dependent manner.
Maintenance treatment with vedolizumab in paediatric inflammatory bowel disease (VEDOKIDS): 54-week outcomes of a multicentre, prospective, cohort study
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 39788134 DOI: 10.1016/S2468-1253(24)00319-4
BACKGROUND: Infliximab and adalimumab are the only biologics thus far approved for paediatric patients with inflammatory bowel disease (IBD), so other biologics, such as vedolizumab, are prescribed off-label. Despite its frequent use, prospective data for vedolizumab treatment in children are available only for short-term induction outcomes. We aimed to evaluate …
Huanglian Ganjiang Decoction alleviates DSS-induced colitis through suppressing inflammation and protecting intestinal barrier: From the perspective of disassembling prescriptions
Publication Year: 2025 Source: J Ethnopharmacol PMID: 39788168
ETHNOPHARMACOLOGICAL RELEVANCE: Huanglian Ganjiang decoction (HGD), which is composed of Chinese medicines with cold, warm, and astringent properties, has demonstrated significant therapeutic efficacy in ulcerative colitis (UC). However, the underlying mechanisms remain unclear, highlighting the need for a multi-faceted investigation. Disassembling prescriptions is a crucial approach for investigating compatibility mechanisms. …
Change in fatigue in patients with ulcerative colitis or Crohn's disease initiating biologic therapy
Publication Year: 2025 Source: Dig Liver Dis PMID: 39788858 DOI: 10.1016/j.dld.2024.12.011
BACKGROUND: Fatigue is common among patients with inflammatory bowel diseases (IBDs) and is associated with decreased quality of life (QoL). AIMS: Describe fatigue evolution and identify factors associated with fatigue outcomes in patients with ulcerative colitis (UC) or Crohn's disease (CD) initiating biologic treatment. METHODS: Data from adult Belgian patients …
Taurine prevents mitochondrial dysfunction and protects mitochondria from reactive oxygen species and deuterium toxicity
Publication Year: 2025 Source: Amino Acids PMID: 39789296
Taurine, although not a coding amino acid, is the most common free amino acid in the body. Taurine has multiple and complex functions in protecting mitochondria against oxidative-nitrosative stress. In this comprehensive review paper, we introduce a novel potential role for taurine in protecting from deuterium (heavy hydrogen) toxicity. This …
Chronic active Epstein‒Barr virus colitis, a rare cause of recurrent diarrhea in an immunocompetent female: a case report
Publication Year: 2025 Source: BMC Infect Dis PMID: 39789451 DOI: 10.1186/s12879-024-10422-z
BACKGROUND: Chronic active Epstein-Barr virus (CAEBV) colitis is a rare disease with clinical and endoscopic manifestations very similar to those of inflammatory bowel disease (IBD). In clinical practice, it is easy to be misdiagnosed and mistreated, leading to poor clinical outcomes. CASE PRESENTATION: We report a case of a 56-year-old …
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