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Early-life antibiotic exposures: Paving the pathway for dysbiosis-induced disorders
Publication Year: 2025 Source: Eur J Pharmacol PMID: 39864578
Microbiota encompasses a diverse array of microorganisms inhabiting specific ecological niches. Gut microbiota significantly influences physiological processes, including gastrointestinal motor function, neuroendocrine signalling, and immune regulation. They play a crucial role in modulating the central nervous system and bolstering body defence mechanisms by influencing the proliferation and differentiation of innate …
Intraoperative Initial Intracranial Pressure Demonstrates High Diagnostic Efficacy for Postoperative Intestinal Mucosal Barrier Dysfunction Following Severe Traumatic Brain Injury
Publication Year: 2025 Source: World Neurosurg PMID: 39864807 DOI: 10.1016/j.wneu.2025.123711
OBJECTIVE: To investigate the risk factors and their diagnostic efficacy for postoperative intestinal mucosal barrier dysfunction (IBD) following severe traumatic brain injury (sTBI). METHODS: There were 140 patients with sTBI enrolled in this study. Univariate and multivariate logistic regression analyses were conducted to assess the relationship between the clinical data …
Intestinal epithelial cell-specific restoration of Nrf2 gene in whole-body-knockout mice ameliorates acute colitis
Publication Year: 2025 Source: Exp Anim PMID: 39864840
Unbalanced redox homeostasis leads to the production of reactive oxygen species and exacerbates inflammatory bowel disease. To investigate the role of the transcription factor Nrf2, a major antioxidative stress sensor, in intestinal epithelial cells (IECs), we generated IEC-specific Nrf2 gene knock-in mice (Nrf2-vRes), which express Nrf2 only in IECs, using …
Actual Use of Budesonide Enteric-Coated Capsules for Crohn's Disease in Japan: Analysis of Health Insurance Big Data
Publication Year: 2025 Source: Biol Pharm Bull PMID: 39864854
Using a large health insurance database in Japan, we examined the real-world usage of budesonide enteric-coated capsules (BUD) in treating Crohn's disease. We analyzed data from the Japan Medical Data Center claims database for Crohn's disease patients prescribed BUD from April 2016 to March 2021, focusing on prescription status, adverse …
Nutraceutical Impact of Pumpkin Seed Oil on Expression Levels of EZH-2 and KRT-14 Genes against DSS-induced Inflammatory Bowel Disease in the Rat Model
Publication Year: 2025 Source: Cell Biochem Biophys PMID: 39865190 DOI: 10.1007/s12013-024-01629-7
Inflammatory bowel disease is a collection of intestinal disorders that cause inflammation in the digestive tract. Prolonged inflammation in the gastrointestinal tract is a major risk factor for colorectal cancer. The objective of this study was to fucus on gene expression levels of (KRT-14; associated with epithelial cell integrity) and …
MC-LR induces and exacerbates Colitis in mice through the JAK1/STAT3 pathway
Publication Year: 2025 Source: J Toxicol Environ Health A PMID: 39865252 DOI: 10.1080/15287394.2024.2443227
Inflammatory bowel disease (IBD) is a complex gastrointestinal disorder attributed to genetic and environmental factors. Microcystin-leucine-arginine (MC-LR) is an environmental toxin that accumulates in the gut and produces intestinal damage. The aim of this study was to investigate the effects of exposure to MC-LR on development and progression of IBD …
Serum Periostin is Able to Stratify Type 2-Dominant Ulcerative Colitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39865279
BACKGROUND: Ulcerative colitis (UC) is a heterogeneous disease composed of different endotypes. It is important to develop useful biomarkers for endotyping UC; however, available biomarkers are insufficient. We have already established that periostin is a surrogate biomarker of type 2 inflammation. In this study, we examined the usefulness of periostin …
Incidence of Venous Thromboembolism in Asian Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 39865330 DOI: 10.1111/jgh.16888
BACKGROUND/AIMS: Although incidence and prevalence of inflammatory bowel disease (IBD) have been gradually increasing throughout Asia, incidence of venous thromboembolism (VTE) in Asia is relatively lower than that in Western and is not well known. This study aimed to evaluate incidence of VTE in Asian IBD patients using a systematic …
Comprehensive care of ulcerative colitis: new treatment strategies
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 39865726
INTRODUCTION: Ulcerative colitis is a chronic inflammatory condition of the colon driven by aberrant immune activation. Although advanced medical therapies form the cornerstone of ulcerative colitis management, unmet needs include failure to induce and sustain remission in a substantial proportion of patients and in managing acute severe ulcerative colitis. We …
From Teeth to Body: The Complex Role of Streptococcus mutans in Systemic Diseases
Publication Year: 2025 Source: Mol Oral Microbiol PMID: 39865888
Streptococcus mutans, the principal pathogen associated with dental caries, impacts individuals across all age groups and geographic regions. Beyond its role in compromising oral health, a growing body of research has established a link between S. mutans and various systemic diseases, including immunoglobulin A nephropathy (IgAN), nonalcoholic steatohepatitis (NASH), infective …
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