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Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis
Publication Year: 2025 Source: Front Mol Neurosci PMID: 39866908 DOI: 10.3389/fnmol.2024.1503396
Multiple sclerosis (MS) affects 2.8 million people worldwide. Although the cause is unknown, various risk factors might be involved. MS involves the immune system attacking the central nervous system's myelin sheath, leading to neuron damage. This study used a cuprizone (CPZ)-intoxicated mouse model to simulate MS's demyelination/remyelination process. It evaluated …
The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases
Publication Year: 2025 Source: Front Mol Neurosci PMID: 39866909 DOI: 10.3389/fnmol.2024.1493308
Multiple sclerosis (MS) is a chronic central nervous system (CNS) disease with demyelinating inflammatory characteristics. It is the most common nontraumatic and disabling disease affecting young adults. The incidence and prevalence of MS have been increasing. However, its exact cause remains unclear. The main tests used to support the diagnosis …
Marginal Zone Lymphoma in a Case of Hidradenitis Suppurativa Treated With Adalimumab Therapy
Publication Year: 2025 Source: J Community Hosp Intern Med Perspect PMID: 39867141
Marginal zone lymphoma has seldom been described in relation to adalimumab used for treatment of hidradenitis suppurativa. Although studies have shown an increased risk of lymphoma with adalimumab, most of these studies were done in patients with underlying inflammatory bowel disease or rheumatoid arthritis where the disease itself presents as …
Efficacy of vagus nerve stimulation in gastrointestinal disorders: a systematic review
Publication Year: 2025 Source: Gastroenterol Rep (Oxf) PMID: 39867596 DOI: 10.1093/gastro/goaf009
Dysfunction of the vagus nerve has been suggested as a contributing factor in various gastrointestinal disorders, prompting interest in vagus nerve stimulation (VNS) as a non-pharmacological therapy. We performed a systematic review to determine the efficacy of invasive and non-invasive VNS in gastrointestinal disorders, including inflammatory bowel disease (IBD), irritable …
Inflammatory bowel disease is associated with an increased risk of cardiovascular events in a sex and age-dependent manner: A historical cohort study
Publication Year: 2025 Source: Int J Cardiol Cardiovasc Risk Prev PMID: 39867747 DOI: 10.1016/j.ijcrp.2025.200363
BACKGROUND: The relationship between inflammatory bowel diseases (IBD) and the risk of ischemic heart diseases (IHD) remains a subject of debate. In this study, we sought to investigate the association between IBD and long-term risk of IHD in a substantial cohort of IBD patients. METHODS: In this retrospective cohort study …
Expression and role of CTHRC1 in inflammatory bowel disease in children
Publication Year: 2025 Source: Cytotechnology PMID: 39867826 DOI: 10.1007/s10616-025-00705-x
Inflammatory bowel disease (IBD) is a chronic, progressive, immune-mediated, gastrointestinal inflammatory disease with increasing occurrences in children. Collagen triple helix repeat containing 1 (CTHRC1), a migration-promoting protein, acts as a tumor-promoting factor in malignant tumors. However, functions and mechanisms of CTHRC1 in children with IBD remain unclear. This study aimed …
Mechanism underlying the role of the circRNA OMA1/miR-654-3p/RAF1 axis in children with inflammatory bowel disease
Publication Year: 2025 Source: Cytotechnology PMID: 39867828 DOI: 10.1007/s10616-025-00703-z
Inflammatory bowel disease (IBD), a chronic gastrointestinal disorder, often emerges during childhood and poses significant challenges due to its adverse effects on growth, development, and psychosocial well-being. Circular RNAs (circRNAs) have been implicated in the pathogenesis of diverse diseases. However, the specific biological role and mechanisms of circRNA OMA1 in …
Inhibition SIRT1 to regulate FOXP3 or RORγt can restore the balance of Treg/Th17 axis in ulcerative colitis and enhance the anti-inflammatory effect of moxibustion
Publication Year: 2025 Source: Front Immunol PMID: 39867884
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Cuproptosis Cell Death Molecular Events and Pathways to Liver Disease
Publication Year: 2025 Source: J Inflamm Res PMID: 39867947 DOI: 10.2147/JIR.S498340
Chronic liver disease ranks as the 11th leading cause of death worldwide, while hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality, representing a substantial risk to public health. Over the past few decades, the global landscape of chronic liver diseases, including hepatitis, metabolic dysfunction-associated steatotic liver disease …
Inflammatory disease microbiomes share a functional pathogenicity predicted by C-reactive protein
Publication Year: 2025 Source: bioRxiv PMID: 39868147
We examine disease-specific and cross-disease functions of the human gut microbiome by colonizing germ-free mice, at risk for inflammatory arthritis, colitis, or neuroinflammation, with over 100 human fecal microbiomes from subjects with rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, ulcerative colitis, Crohn's disease, or colorectal cancer. We find common inflammatory phenotypes …
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