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Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR(2)
Publication Year: 2025 Source: bioRxiv PMID: 39868234
Protease-activated receptor 2 (PAR(2)) is a central regulator of intestinal barrier function, inflammation and pain. Upregulated intestinal proteolysis and PAR(2)-signaling are implicated in inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS). To identify potential bacterial regulators of PAR(2) activity, we developed a functional assay for PAR(2) processing and used …
Pseudohypoparathyroidism type 1A presenting as short stature and congenital hypothyroidism
Publication Year: 2025 Source: Endocrinol Diabetes Metab Case Rep PMID: 39868553
SUMMARY: Short stature is a common complaint among pediatric visits and the differential diagnosis is extensive. Although some variations in growth are normal, deviation from normal growth is often the first symptom of chronic disease in children. This is true for hormone abnormalities including growth hormone deficiency, hypothyroidism and glucocorticoid …
Cardiovascular, cancer, and infection risks of Janus kinase inhibitors in rheumatoid arthritis and ulcerative colitis: A nationwide cohort study
Publication Year: 2025 Source: J Intern Med PMID: 39868841
BACKGROUND: Evolving evidence suggests that patients undergoing treatment with Janus kinase inhibitors (JAKi) may face an increased risk of cardiovascular events, malignancies, and serious infections. OBJECTIVES: We assessed cardiovascular, malignancy, and serious infection risks associated with JAKi use compared to tumor necrosis factor inhibitor (TNFi) use, which served as the …
Anti-tumor Necrosis Factor Drug Concentration Is Not Associated with Disease Outcomes in Pouchitis: A Retrospective, International Study
Publication Year: 2025 Source: Dig Dis Sci PMID: 39869163
BACKGROUND: Therapeutic drug monitoring is important for optimizing anti-tumor necrosis factor-alpha (TNF-alpha) therapy in inflammatory bowel disease. However, the exposure-response relationship has never been assessed in pouchitis. AIMS: To explore associations between anti-TNF-alpha drug concentration and pouchitis disease activity in patients with a background of ulcerative colitis. METHODS: A retrospective, …
Fast, Present and Future of the Concept of Spondyloarthritis
Publication Year: 2025 Source: Curr Rheumatol Rep PMID: 39869233 DOI: 10.1007/s11926-024-01179-0
PURPOSE OF REVIEW: Axial spondyloarthritis (axSpA) is a rather prevalent chronic inflammatory rheumatic disease that affects already relatively young patients. It has been known better since the end of the nineteenth century but quite a lot has been learned since the early 60ies when the first classification (diagnostic) criteria for …
Global trends in surgically based treatment of anal fistula in Crohn's disease: a bibliometric and visualization analysis
Publication Year: 2025 Source: Int J Surg PMID: 39869383
BACKGROUND: Crohn's disease (CD) is a chronic, recurrent gastrointestinal disorder characterized by a complex etiology. Among its perianal complications, anal fistulas represent a challenging comorbidity. With the increase of surgical options, a comprehensive bibliometric analysis was deemed necessary to consolidate the vast array of research in this field. METHODS: We …
Approach to Therapy for Chronic Pouchitis
Publication Year: 2025 Source: Annu Rev Med PMID: 39869428
Chronic pouchitis (CP) occurs in approximately 20% of patients with ulcerative colitis after total proctocolectomy with ileal pouch anal anastomosis and is categorized as antibiotic dependent, antibiotic refractory, or Crohn's disease-like. The management of CP is challenging because of limited evidence and few randomized controlled trials. In this review, we …
Assessment and management for latent tuberculosis before advanced therapies for immune-mediated inflammatory diseases: A comprehensive review
Publication Year: 2025 Source: Autoimmun Rev PMID: 39870187
Tuberculosis (TB), caused by Mycobacterium tuberculosis , is the most significant infectious cause of mortality across the globe. While TB disease can prey on immunocompetent individuals, it is more likely to occur in immunocompromised individuals. Immune-mediated inflammatory diseases (IMIDs) are a group of diseases (rheumatoid arthritis, inflammatory bowel disease, ankylosing …
Burden and Social Determinants of Health in Pediatric Inflammatory Bowel Disease: Lessons Learned From Epidemiologic Studies Using Health Administrative Data
Publication Year: 2025 Source: Gastroenterology PMID: 39870222
No Abstract
Oral tributyrin treatment affects short-chain fatty acid transport, mucosal health, and microbiome in a mouse model of inflammatory diarrhea
Publication Year: 2025 Source: J Nutr Biochem PMID: 39870330
Butyrate may decrease intestinal inflammation and diarrhea. This study investigates the impact of oral application of sodium butyrate (NaB) and tributyrin (TB) on colonic butyrate concentration, SCFA transporter expression, colonic absorptive function, barrier properties, inflammation, and microbial composition in the colon of slc26a3(-/-) mice, a mouse model for inflammatory diarrhea. …
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