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Changyanning tablet alleviates Crohn's disease by inhibiting GPX4-mediated ferroptosis
Publication Year: 2025 Source: J Ethnopharmacol PMID: 39870334
ETHNOPHARMACOLOGICAL RELEVANCE: Changyanning tablets (CYN) are a marketed traditional Chinese medicine composed of Diijincao (Euphorbia humifusa Willd.), Jinmaoercao (Hedyotis chrysotricha (Palib.) Merr.), Zhangshugen (root of Cinnamomum camphora (L.) J.Presl), Xiangru (Elsholtzia ciliate (Thunb.) Hyl.), and Fengxiangshuye (leaf of Liquidambar formosana Hance). They possess the functions of clearing heat, removing dampness, …
In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier
Publication Year: 2025 Source: Gut PMID: 39870396
BACKGROUND: Non-absorbed dietary emulsifiers, including carboxymethylcellulose (CMC), directly disturb intestinal microbiota, thereby promoting chronic intestinal inflammation in mice. A randomised controlled-feeding study (Functional Research on Emulsifiers in Humans, FRESH) found that CMC also detrimentally impacts intestinal microbiota in some, but not all, healthy individuals. OBJECTIVES: This study aimed to establish …
Identification of ubiquitination-related key biomarkers and immune infiltration in Crohn's disease by bioinformatics analysis and machine learning
Publication Year: 2025 Source: Sci Rep PMID: 39870856
Crohn's disease (CD) is a chronic inflammatory bowel disease with an unknown etiology. Ubiquitination plays a significant role in the pathogenesis of CD. This study aimed to explore the functional roles of ubiquitination-related genes in CD. Differentially expressed ubiquitination-related genes were identified by intersecting differentially expressed genes (DEGs) from the …
[The intestinal microbiota in inflammatory bowel diseases]
Publication Year: 2025 Source: Inn Med (Heidelb) PMID: 39870907 DOI: 10.1007/s00108-024-01845-6
BACKGROUND: The intestinal microbiota comprises all living microorganisms in the gastrointestinal tract and is crucial for its function. Clinical observations and laboratory findings confirm a central role of the microbiota in chronic inflammatory bowel diseases (IBD). However, many mechanistic details remain unclear. OBJECTIVES: Changes in the microbiota and the causal …
Usefulness of Novel Image-Enhanced Endoscopy for Predicting Maintenance of Clinical Remission in Ulcerative Colitis
Publication Year: 2025 Source: Dig Dis Sci PMID: 39870961
PURPOSE: The performance of endoscopic evaluation of ulcerative colitis (UC) using conventional scoring, including Mayo endoscopic subscore (MES) and ulcerative colitis endoscopic index of severity (UCEIS), is not satisfactory. Recently, the usefulness of novel image-enhanced endoscopy (IEE) such as texture and color enhancement imaging (TXI) and red dichromatic imaging (RDI) …
Role of the gut microbiome in psychological symptoms associated with inflammatory bowel diseases
Publication Year: 2025 Source: Semin Immunopathol PMID: 39870972
The brain-gut axis constitutes the basis for the bidirectional communication between the central nervous system and the gastrointestinal tract driven by neural, hormonal, metabolic, immunological, and microbial signals. Alterations in the gut microbiome composition as observed in inflammatory bowel diseases can modulate brain function and emerging empirical evidence has indicated …
Computed tomography enterography-based radiomics nomograms to predict inflammatory activity for ileocolonic Crohn's disease: a preliminary single-center retrospective study
Publication Year: 2025 Source: BMC Med Imaging PMID: 39871226
OBJECTIVES: This study aims to develop and validate nomograms that utilize morphological and radiomics features derived from computed tomography enterography (CTE) to evaluate inflammatory activity in patients with ileocolonic Crohn's disease (CD). METHODS: A total of 54 CD patients (237 bowel segments) with clinically confirmed CD were retrospectively analyzed. The …
Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach
Publication Year: 2025 Source: J Health Popul Nutr PMID: 39871318
BACKGROUND: The human gut microbiota has a critical role in several aspects of host homeostasis, such as immune development, metabolism, nutrition, and defense against pathogens during life. It can be sensitive to xenobiotics including drugs, diet, or even environmental pollutants, especially heavy metals (HMs). The findings of some previous studies …
Systemic Inflammatory Diseases in Children With Sickle Cell Disease: A French Multicenter Observational Study on Diagnostic and Therapeutic Issues
Publication Year: 2025 Source: Pediatr Blood Cancer PMID: 39871404 DOI: 10.1002/pbc.31563
BACKGROUND: Systemic inflammatory diseases (SIDs) have been reported in patients with sickle cell disease (SCD), but clinical data in children are scarce. OBJECTIVES: To identify clinical and laboratory features at diagnosis of SID in children with SCD and to describe their evolution. METHODS: Data from children with SCD and SIDs …
Maintenance-phase serum anti-TNF levels are not associated with mucosal healing in pediatric Crohn's disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39871722
OBJECTIVES: Mucosal healing (MH) is a key therapeutic target in Crohn's disease (CD) and is associated with improved outcomes. While adult studies indicate a positive correlation between serum anti-tumor necrosis factor (TNF) levels and MH, data in pediatric patients is limited. We aimed to define the association of serum anti-TNF …
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