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Neutrophils: From Inflammatory Bowel Disease to Colitis-Associated Colorectal Cancer
Publication Year: 2025 Source: J Inflamm Res PMID: 39871958 DOI: 10.2147/JIR.S497701
Inflammatory bowel disease (IBD) is a non-specific inflammatory disease of digestive tract, primarily manifesting as ulcerative colitis (UC) and Crohn's disease (CD). The precise etiology of IBD remains elusive. The interplay of genetic factors, environmental influences, and intestinal microbiota contributes to the establishment of an uncontrolled immune environment within the …
Disseminated Chickenpox Following Live Varicella Vaccination in a Crohn's Disease Patient on Combination Immunosuppression
Publication Year: 2025 Source: Case Rep Gastrointest Med PMID: 39872708
Novel therapeutics used in the treatment of inflammatory bowel disease pose an increased risk of viral reactivation in patients. We present a case of a patient with refractory Crohn's disease (CD) who developed primary varicella (chickenpox) of a vaccine-viral strain after receiving combination immunosuppression with high-dose corticosteroids, tumor necrosis factor …
Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials
Publication Year: 2025 Source: Front Cell Dev Biol PMID: 39872845 DOI: 10.3389/fcell.2024.1452258
Telocytes, a novel mesenchymal cell population, are characterized by their distinctive long and slender projections known as telopodes and have garnered significant interest since their formal introduction to the literature in 2010. These cells have been identified in various tissues, including the gastrointestinal (GI) tract, where they are suggested to …
Confocal Endomicroscopy Intestinal Epithelial Barrier Abnormalities in Individuals Without Documented Gastro-Intestinal Disease
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39873272 DOI: 10.1002/ueg2.12756
BACKGROUND AND AIMS: Probe-based confocal endomicroscopy (pCLE) allows real-time microscopic visualization of the intestinal mucosa surface layers. Despite remission achieved through anti-tumor necrosis factor or vedolizumab therapy, anomalies in the intestinal epithelial barrier are observed in inflammatory bowel disease (IBD) patients. Our study aimed to assess these abnormalities in non-IBD …
C9orf72 Alleviates DSS‑Induced Ulcerative Colitis via the cGAS-STING Pathway
Publication Year: 2025 Source: Immun Inflamm Dis PMID: 39873292
PURPOSE: C9orf72 deficiency contributes to severe inflammation in mice. Ulcerative colitis (UC) is a chronic inflammatory disorder with the shortage of clinical success. However, whether C9orf72 is involved in the progression of UC is not fully understood. This study investigated whether C9orf72 could alleviate dextran sulfate sodium (DSS)-induced colitis in …
Bisdemethoxycurcumin and Curcumin Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice
Publication Year: 2025 Source: J Agric Food Chem PMID: 39873626 DOI: 10.1021/acs.jafc.4c11101
Curcuminoids, found in turmeric (Curcuma longa L.), include curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). Although CUR and DMC are well-studied, the anti-inflammatory effects of BDMC remain less explored. Recent studies highlight BDMC's stronger NF-kappaB inhibition compared to CUR and DMC in cell models, along with its ability to target …
Evaluating the efficacy of nano-cyclosporine A in mice model of ulcerative colitis: a meta-analysis
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 39873716
Cyclosporine A is an immunosuppressive drug used in clinics to treat steroid-refractory ulcerative colitis (UC). However, due to its side effects, researchers are evaluating novel drug delivery-based treatment options. Nanoparticles-based cyclosporine (Nano-CSA) offers a promising option for the treatment of UC, and various in vivo studies on animals have been …
TTC7A Variants Results in Gastrointestinal Defects and Immunodeficiency Syndrome: Case Series and Literature Review
Publication Year: 2025 Source: Clin Rev Allergy Immunol PMID: 39873864 DOI: 10.1007/s12016-024-09017-y
Gastrointestinal Defects and Immunodeficiency Syndrome-1 (GIDID-1), caused by abnormalities in TTC7A, is an autosomal recessive disorder characterized by multiple gastrointestinal malformations and immune deficiencies, often accompanied by inflammatory bowel disease (IBD). This condition typically results in poor treatment outcomes and is usually fatal in early infancy. This paper examined the …
Effects of inflammatory bowel diseases on sexual function in women
Publication Year: 2025 Source: Ir J Med Sci PMID: 39873965 DOI: 10.1007/s11845-025-03890-y
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic disease that includes Crohn's disease and ulcerative colitis. Studies found that 40-60% of women diagnosed with IBD have sexual dysfunction (SD). AIMS: To determine SD and associated factors in women with IBD. METHODS: Female patients diagnosed with IBD in the Gastroenterology Department …
Correlation Between Rumination, Symptom Clusters, and Quality of Life in Patients With Inflammatory Bowel Disease: A Cross-Sectional Study
Publication Year: 2025 Source: Gastroenterol Nurs PMID: 39874115 DOI: 10.1097/SGA.0000000000000835
Previous studies have demonstrated that individuals with inflammatory bowel disease (IBD) experience distinct symptom clusters and generally have a lower quality of life compared to the general population. Rumination refers to the persistent and repetitive contemplation of the causes, consequences, and intricate details of a negative and stressful event. The …
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