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Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders
Publication Year: 2025 Source: Ann Rheum Dis PMID: 39874239 DOI: 10.1136/ard-2024-225829
OBJECTIVES: This study aims to elucidate the microbial signatures associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), compared with colorectal cancer (CRC), to identify unique biomarkers and shared microbial mechanisms that could inform specific treatment protocols. METHODS: We analysed metagenomic datasets from patient cohorts …
Bridging the Gap Between Explanatory and Pragmatic Trials in Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39874269
No Abstract
Racial disparities in extended venous thromboembolism prophylaxis after hysterectomy
Publication Year: 2025 Source: PLoS One PMID: 39874351
BACKGROUND: Venous thromboembolism (VTE) is a significant preventable cause of postoperative morbidity and mortality after major abdominopelvic surgery that calls for extended VTE prophylaxis (eVTEp). Literature suggests that significant racial disparities may exist in post-operative care. OBJECTIVE: The study sought to examine if racial disparities exist in the administration of …
High risk and low incidence diseases: Stercoral colitis
Publication Year: 2025 Source: Am J Emerg Med PMID: 39874678
INTRODUCTION: Stercoral colitis is a rare but serious diagnosis which is associated with a high rate of morbidity. OBJECTIVE: This review highlights the pearls and pitfalls of stercoral colitis, including presentation, diagnosis, and emergency department (ED) management based on the available evidence. DISCUSSION: Stercoral colitis is an uncommon inflammatory condition …
Ischemic ulcers do not significantly impact endoscopic recurrence score in Crohn's disease: A multicenter comparative study after right-side colectomy
Publication Year: 2025 Source: Dig Liver Dis PMID: 39875231
BACKGROUND: Postoperative recurrence (POR) occurs in up to 70% of patients with Crohn's disease (CD). The Rutgeerts score (RS) system may overestimate the prevalence of "real" anastomotic recurrence. Hence, we aimed to compare the prevalence of anastomotic POR in CD and the presence of ulcers at anastomotic sites in patients …
Coeliac disease: complications and comorbidities
Publication Year: 2025 Source: Nat Rev Gastroenterol Hepatol PMID: 39875649
Coeliac disease is an autoimmune disease characterized by small intestinal villus atrophy and inflammation upon exposure to gluten. It has a global prevalence of approximately 1%. Although the gluten-free diet can be an effective treatment, this diet is burdensome with practical difficulties and frequent inadvertent gluten exposure. Moreover, there are …
Gastrointestinal complications of hepatic glycogen storage disease: a national survey questionnaire study in China
Publication Year: 2025 Source: Orphanet J Rare Dis PMID: 39875987 DOI: 10.1186/s13023-025-03570-1
BACKGROUND: Hepatic glycogen storage diseases (GSD) are inborn errors of metabolism with abnormal storage or utilization of glycogen, a complex disease with significant genetic heterogeneity and similar clinical manifestations. This study aimed to describe the gastrointestinal symptoms and endoscopic features of hepatic GSD, including types Ia, Ib, III, VI, and …
E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration
Publication Year: 2025 Source: J Exp Clin Cancer Res PMID: 39876002 DOI: 10.1186/s13046-024-03271-w
BACKGROUND: Bacterial toxins are emerging as promising hallmarks of colorectal cancer (CRC) pathogenesis. In particular, Cytotoxic Necrotizing Factor 1 (CNF1) from E. coli deserves special consideration due to the significantly higher prevalence of this toxin gene in CRC patients with respect to healthy subjects, and to the numerous tumor-promoting effects …
Nonsurgical Treatment of Splenic Abscesses in Patient With Simultaneous Diagnosis of Endocarditis and Crohn's Disease: A Case Report and Literature Review
Publication Year: 2025 Source: Clin Case Rep PMID: 39876927 DOI: 10.1002/ccr3.70161
The spleen is one site for septic emboli in cases of IE but in patients with splenic abscess when the patient has a suspicious history of autoimmune diseases, splenic aseptic abscess must be ruled out before splenectomy.
Polydatin protects against DSS-induced ulcerative colitis via Nrf2/Slc7a11/Gpx4-dependent inhibition of ferroptosis signalling activation
Publication Year: 2025 Source: Front Pharmacol PMID: 39877390
No Abstract
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