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Imaging characteristics of brain microstructure and cerebral perfusion in Crohn's disease patients with anxiety: A prospective comparative study
Publication Year: 2025 Source: World J Gastroenterol PMID: 39877713
BACKGROUND: Anxiety is a common comorbidity in patients with Crohn's disease (CD). Data on the imaging characteristics of brain microstructure and cerebral perfusion in CD with anxiety are limited. AIM: To compare the imaging characteristics of brain microstructure and cerebral perfusion among CD patients with or without anxiety and healthy …
Clinical entity-aware domain adaptation in low resource setting for inflammatory bowel disease
Publication Year: 2025 Source: Front Artif Intell PMID: 39877750 DOI: 10.3389/frai.2024.1450477
The digitization of healthcare records has revolutionized medical research and patient care, with electronic health records (EHRs) containing a wealth of structured and unstructured data. Extracting valuable information from unstructured clinical text presents a significant challenge, necessitating automated tools for efficient data mining. Natural language processing (NLP) methods have been …
The diagnostic accuracy of plasma and serum calprotectin is inferior to C-reactive protein in patients with suspected Crohn's disease
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 39878038
BACKGROUND AND AIMS: Prior studies indicate that serum calprotectin (SC) and plasma calprotectin (PC) can be used as biomarkers in Crohn's disease (CD). The aim of this study was to investigate the diagnostic accuracy of SC and PC in patients with a clinical suspicion of CD. METHOD: This biobank study …
The Role of Environmental Factors Prior to Diagnosis on the Activity and Severity of Inflammatory Bowel Diseases-Results From the Prospective Population-Based Copenhagen Inflammatory Bowel Disease Inception Cohort
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39878314 DOI: 10.1002/ueg2.12737
BACKGROUND: The influence of environmental factors on the severity of early inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is unclear. Herein, we aimed to investigate the role of environmental factors in the initial phenotype, activity, and severity of IBD. METHODS: Copenhagen IBD Inception Cohort is …
Inadequate Therapy Response on Advanced Therapy in Ulcerative Colitis Adult Patients: A Retrospective Analysis of German Health Claims Data
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39878360
BACKGROUND: The treatment landscape for active ulcerative colitis is rapidly evolving and current real-world evidence on response to advanced therapy is limited. This study aimed to determine indicators of inadequate therapeutic response among patients with ulcerative colitis in Germany initiating advanced therapy. METHODS: This retrospective analysis used German claims data …
Body Mass Index Did Not Affect Efficacy and Safety of Etrasimod: A Post Hoc Analysis of the ELEVATE Ulcerative Colitis Clinical Program
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39878434
INTRODUCTION: High body mass index (BMI) may reduce ulcerative colitis (UC) treatment efficacy. Etrasimod is an oral, once-daily (QD), selective sphingosine 1-phosphate 1,4,5 receptor modulator for the treatment of moderately to severely active UC. This post hoc analysis assessed treatment outcomes according to BMI in ELEVATE UC 52 and ELEVATE …
Comparative Improvement in Health-Related Quality of Life With Advanced Therapies for Moderate-to-Severe Crohn's Disease: A Network Meta-Analysis
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39878444
INTRODUCTION: The comparative efficacy of advanced therapies to improve health-related quality of life (HR-QoL) in Crohn's disease (CD) is unknown. We aimed to compare the impact of approved advanced therapies for moderate-to-severe CD on HR-QoL. METHODS: We searched MEDLINE, Embase, and Cochrane CENTRAL from inception to December 2023. We included …
Human-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transcripts in the gut commensal Bacteroides thetaiotaomicron
Publication Year: 2025 Source: mBio PMID: 39878512
In the gut, microRNAs (miRNAs) produced by intestinal epithelial cells are secreted into the lumen and can shape the composition and function of the gut microbiome. Crosstalk between gut microbes and the host plays a key role in irritable bowel syndrome (IBS) and inflammatory bowel diseases, yet little is known …
Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin in ulcerative colitis
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 39878817
Ulcerative colitis is a long-term inflammatory colon illness that significantly affects patients quality of life. Traditional medicines and therapies often come with challenges such as side effects, instability, unpredictability, and high costs. This has captured interest in natural products that have huge health benefits. Various natural compounds, including resveratrol, curcumin, …
The CT findings of extranodal natural killer/T-cell lymphoma, nasal type involving the gastrointestinal tract
Publication Year: 2025 Source: Eur Radiol PMID: 39878902
OBJECTIVES: To analyze the CT imaging features of extranodal natural killer/T (NK/T)-cell lymphoma, nasal type (ENKTCL-NT) involving the gastrointestinal tract (GI), and to compare them with those of Crohn's disease (CD) and diffuse large B-cell lymphoma (DLBCL). MATERIALS AND METHODS: Data were retrospectively collected from 17 patients diagnosed with GI …
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