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[The gastrointestinal microbiome - vision and mission]
Publication Year: 2025 Source: Dtsch Med Wochenschr PMID: 39879970 DOI: 10.1055/a-2303-3368
The gastrointestinal microbiome influences physiological functions and is altered in a variety of diseases. The causality of "dysbiosis" in the pathogenesis is not always proven; association studies are often involved. Patients with IBD, bacteria, fungi, bacteriophages, and archaea show disease-typical patterns associated with metabolome disturbances. Fecal microbiome transfer (FMT) for …
Polysaccharide from steamed Polygonatum sibiricum ameliorates ulcerative colitis by protecting the intestinal mucosal barrier and regulating gut microbiota
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39880230
Steamed Polygonatum sibiricum is widely applied in clinical practice for its tonic effect on gastrointestinal tract. A novel polysaccharide named PSSP-EF was extracted from the steamed roots of Polygonatum sibiricum using hot water extraction, ethanol precipitation, and chromatographic purification. PSSP-EF, with a molecular weight of 2.24 x 10(4) Da, was …
Listening to the voices of adolescents with inflammatory bowel disease after returning to school: a qualitative study
Publication Year: 2025 Source: Arch Dis Child PMID: 39880591 DOI: 10.1136/archdischild-2024-328010
BACKGROUND: The prevalence of inflammatory bowel disease (IBD) among Chinese adolescents has continued to increase in recent years. Adolescents with IBD interrupted their schooling due to the diagnosis and treatment of the disease. And when the condition stabilises, they will return to school. However, as a lifelong and recurrent disease, …
Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis
Publication Year: 2025 Source: Gut PMID: 39880602
BACKGROUND: The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and difficult to predict. This is a major challenge for effective clinical management. OBJECTIVE: We aimed to provide accurate AN risk stratification in UC …
A Hepatic Oxidative Metabolite of Palmatine Ameliorates DSS-Induced Ulcerative Colitis by Regulating Macrophage Polarization Through AMPK/NF-κB Pathway
Publication Year: 2025 Source: Am J Chin Med PMID: 39880666
Palmatine (PAL) and berberine are both classified as protoberberine alkaloids, derived from several traditional Chinese herbs such as Coptis chinensis Franch. and Phellodendron chinense Schneid. These compounds are extensively used in treating dysentery and colitis. PAL is one of the crucial quality markers for these plants in the Chinese Pharmacopoeia. …
Responsiveness and clinical utility of PROMIS instruments in pediatric Crohn's disease: insights from a longitudinal study
Publication Year: 2025 Source: Front Pediatr PMID: 39882211 DOI: 10.3389/fped.2024.1473286
BACKGROUND: Inflammatory bowel disease (IBD) may adversely affect physical, psychological, and social well-being. Integrating patient-reported outcomes (PROs) into clinical practice is crucial for comprehensive disease management. OBJECTIVE: To evaluate the responsiveness and clinical utility of Patient-Reported Outcomes Measurement Information System (PROMIS) instruments, compared with standard clinical assessment tools in pediatric …
Gastroenterological Surgery and Management of Clostridioides difficile Infection: A Review
Publication Year: 2025 Source: J Anus Rectum Colon PMID: 39882219
Fever and diarrhea are the common symptoms of Clostridioides difficile infection (CDI); however, pseudomembranous enteritis, megacolonization, and paralytic ileus have been observed in severe cases. C. difficile spores are resistant to several types of disinfectants. Thus, they are often the causative pathogens of healthcare-associated infections. Rapid diagnostic tests based on …
Management of Anal Fistula with Crohn's Disease
Publication Year: 2025 Source: J Anus Rectum Colon PMID: 39882221
Crohn's disease (CD) causes gastrointestinal symptoms (i.e., diarrhea and abdominal pain), systemic symptoms (i.e., fatigue, anemia, weight loss, and fever), and perianal fistulas that produce anal pain. Because of the frequent occurrence of diarrhea and ulcers in the rectum, CD is often exacerbated by perianal abscesses and/or fistulas. Perianal fistulizing …
Case report: Successful therapy with recombinant human vascular endostatin in an elderly man with colon telangiectasia and idiopathic thrombocytopenic purpura
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 39882531
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Sleep Deficiency and Fatigue in Adults with Inflammatory Bowel Disease: A Systematic Review
Publication Year: 2025 Source: West J Nurs Res PMID: 39882819
PURPOSE: Fatigue is one of the most common and disabling symptoms experienced by people with inflammatory bowel disease; however, interventions to treat fatigue are limited. The purpose of this systematic review is to examine the relationship between sleep deficiency and fatigue in adults with inflammatory bowel disease and to describe …
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