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Insulin sensitivity in moderately severe to acute severe ulcerative colitis
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 39882844
BACKGROUND: Patients hospitalized with moderately severe or acute severe ulcerative colitis (UC) may experience metabolic disturbances, including alterations in insulin resistance due to inflammation and the administration of glucocorticoids (GCs). This pilot study aimed to evaluate insulin sensitivity in patients hospitalized for moderately severe to severe UC. METHOD: Patients hospitalized …
Generalizability of Randomized Controlled Trials to Routine Clinical Care in Ulcerative Colitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39883071 DOI: 10.1093/ibd/izaf012
BACKGROUND: Historically, randomized controlled trials (RCTs) have been criticized for being poorly generalizable to patients with ulcerative colitis (UC) evaluated in routine care. We aimed to evaluate the proportion of patients with UC starting an advanced therapy who would be eligible to participate in phase 3 registrational UC RCTs. METHODS: …
[An update on surgical treatment options for inflammatory bowel disease]
Publication Year: 2025 Source: Inn Med (Heidelb) PMID: 39883175 DOI: 10.1007/s00108-024-01846-5
There are national and international guidelines and developments for the surgery of chronic inflammatory bowel disease (IBD) that contribute to better patient care. Important recommendations include increasingly individualized and minimally invasive approaches with the integration of new technologies. The indication for abdominal surgery remains tied to specialization, not least in …
Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues
Publication Year: 2025 Source: Inflamm Res PMID: 39883179 DOI: 10.1007/s00011-024-01970-w
BACKGROUND: The aberrant expression of alpha defensin 5 (DEFA5) protein in colonic inflammatory bowel diseases (IBDs) underlies the distinct pathogenesis of Crohn's colitis (CC). It can serve as a biomarker for differentiating CC from Ulcerative colitis (UC), particularly in Indeterminate colitis (IC) cases into UC and CC. We evaluated the …
First-line biologics as a treatment for ulcerative colitis: a multicenter randomized control study
Publication Year: 2025 Source: J Gastroenterol PMID: 39883201
BACKGROUND: Despite the availability of several biologics for ulcerative colitis (UC), there remains a critical need to identify first-line treatment biologics. The superiority of infliximab (IFX) over vedolizumab (VED) and ustekinumab (UST) was evaluated as initial UC treatments in patients with biologic-naive UC. METHODS: This multicenter, randomized control trial was …
Automatic Quality Control System and Adenoma Detection Rates During Routine Colonoscopy: A Randomized Clinical Trial
Publication Year: 2025 Source: JAMA Netw Open PMID: 39883463
IMPORTANCE: High-quality colonoscopy reduces the risks of colorectal cancer by increasing the adenoma detection rate. Routine use of an automatic quality control system (AQCS) to assist in colorectal adenoma detection should be considered. OBJECTIVE: To evaluate the effect of an AQCS on the adenoma detection rate among colonoscopists who were …
Orally-administrable supramolecular probiotic capsules enable cooperative colon-targeted inflammation inhibition for ameliorating ulcerative colitis
Publication Year: 2025 Source: Acta Biomater PMID: 39884521
Ulcerative colitis (UC) is a prevalent gastrointestinal disease characterized by the chronical and refractory inflammation of colorectal mucosa and walls, which severely impairs overall well-being of individuals. Probiotics has shown tremendous promise for UC therapy due to its multifaceted mucosal barrier restoration and immunomodulation capabilities. Nevertheless, the successful administration of …
Prostaglandin E(2) and Akt Promote Stemness in Apc Mutant Dclk1+ Cells to Give Rise to Colitis-associated Cancer
Publication Year: 2025 Source: Cell Mol Gastroenterol Hepatol PMID: 39884575
BACKGROUND & AIMS: Loss of the tumor suppressor gene Apc in Lgr5+ intestinal stem cells results in aberrant Wnt signaling and colonic tumorigenesis. In the setting of injury, however, we and others have also shown that non-stem cells can give rise to colonic tumors. The mechanism by which inflammation leads …
Impact of histologic disease activity on long-term outcomes in patients with ileal pouch-anal anastomosis for ulcerative colitis
Publication Year: 2025 Source: Dig Liver Dis PMID: 39884896 DOI: 10.1016/j.dld.2025.01.180
BACKGROUND: Ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) can incur in complications. The impact of histological activity on the development of pouch-related complications is poorly studied. AIM: To assess the association between histology and long-term outcomes in UC-IPAA. METHODS: Single-center, ambidirectional cohort study including UC-IPAA patients undergoing pouchscopy after …
Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status
Publication Year: 2025 Source: Nat Commun PMID: 39885121
Ruminococcus gnavus is a gut bacterium found in > 90% of healthy individuals, but its increased abundance is also associated with chronic inflammatory diseases, particularly Crohn's disease. Nevertheless, its global distribution and intraspecies genomic variation remain understudied. By surveying 12,791 gut metagenomes, we recapitulated known associations with metabolic diseases and …
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