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Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids
Publication Year: 2025 Source: Sci Rep PMID: 39885201 DOI: 10.1038/s41598-025-86314-2
Restoration of the intestinal epithelial barrier is crucial for achieving mucosal healing, the therapeutic goal for inflammatory bowel disease (IBD). During homeostasis, epithelial renewal is maintained by crypt stem cells and progenitors that cease to divide as they differentiate into mature colonocytes. Inflammation is a major effector of mucosal damage …
Milk-derived extracellular vesicles and gut health
Publication Year: 2025 Source: NPJ Sci Food PMID: 39885215 DOI: 10.1038/s41538-025-00375-1
Milk is a nutrient-rich liquid produced by mammals, offering various health benefits due to its composition of proteins, fats, carbohydrates, vitamins, and minerals. Beyond traditional nutritional aspects, recent research has focused on extracellular vesicles (EVs) found in milk and their potential health benefits, especially for gastrointestinal (GI) health. Milk-derived EVs …
Mendelian randomization analysis does not support a causal influence between lipoprotein(A) and immune-mediated inflammatory diseases
Publication Year: 2025 Source: Sci Rep PMID: 39885280 DOI: 10.1038/s41598-025-88375-9
Observational studies have reported an association between lipoprotein(a) (Lp(a)) and immune-mediated inflammatory diseases (IMIDs). This study used Mendelian Randomization (MR) and multivariable MR (MVMR) to explore the causal relationship between lipoprotein(a) [Lp(a)] and immune-mediated inflammatory diseases (IMIDs). We performed a bidirectional two-sample mendelian randomization analyses based on genome-wide association study …
Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis
Publication Year: 2025 Source: J Transl Med PMID: 39885523
BACKGROUND: Psoriasis is a common chronic, recurrent, immune-mediated disease involved in the skin or joints or both. However, deeper insight into the genetic susceptibility of psoriasis is still unclear. METHODS: Here we performed the largest multi-ancestry meta-analysis of genome-wide association study including 28,869 psoriasis cases and 443,950 healthy controls. RESULTS: …
A child with Chronic Nonbacterial Osteomyelitis and celiac disease: accidental association or two different aspects of the same condition?
Publication Year: 2025 Source: Ital J Pediatr PMID: 39885545 DOI: 10.1186/s13052-025-01842-x
BACKGROUND: Chronic Nonbacterial Osteomyelitis (CNO) is a rare auto-inflammatory disease that mainly affects children, and manifests with single or multiple painful bone lesions. Due to the lack of specific laboratory markers, CNO diagnosis is a matter of exclusion from different conditions, first and foremost bacterial osteomyelitis and malignancies. Whole Body …
Genetic polymorphisms impacting clinical pharmacology of drugs used to treat inflammatory bowel disease: a precursor to multi-omics approach to precision medicine
Publication Year: 2025 Source: Expert Rev Clin Immunol PMID: 39885730 DOI: 10.1080/1744666X.2025.2461584
INTRODUCTION: Inflammatory bowel diseases (IBDs), comprised of ulcerative colitis (UC) and Crohn's disease (CD), are chronic inflammatory diseases of the gastrointestinal tract. Clinicians and patients must vigilantly manage these complex diseases over the course of the patient's lifetime to mitigate risks of the disease, surgical complications, progression to neoplasia, and …
A Severe Case of Disseminated Herpes Zoster in a Patient With Crohn's Disease on Upadacitinib Who Completed the Recombinant Zoster Vaccine Series
Publication Year: 2025 Source: ACG Case Rep J PMID: 39886013
Herpes zoster (HZ) is caused by the reactivation of the varicella zoster virus and presents with painful vesicular lesions in a dermatomal distribution. Disseminated HZ occurs when skin lesions erupt in numerous dermatomes. Upadacitinib is the first oral medication approved to treat moderate-severe Crohn's disease and has been associated with …
Mendelian randomization studies of risk and protective factors for osteoporosis: a systematic review and meta-analysis
Publication Year: 2025 Source: Front Endocrinol (Lausanne) PMID: 39886030
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Patient Advisory Groups in Inflammatory Bowel Disease: A Collaborative Relationship Between Patients and Researchers
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 39886525
BACKGROUND: Patient advisory groups are key to guiding research studies through meaningful engagement with the population of interest. Although patient advisory groups are greatly valuable to research studies, they are underutilized in inflammatory bowel disease research. Thus, this study aims to describe the development and implementation of a patient advisory …
PMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression
Publication Year: 2025 Source: Gut Microbes PMID: 39886799 DOI: 10.1080/19490976.2025.2455508
Candida albicans (C. albicans) exhibits aberrant changes in patients with colitis, and it has been reported to dominate the colonic mucosal immune response. Here, we found that PMA1 expression was significantly increased in C. albicans from patients with IBD compared to that in healthy controls. A Crispr-Cas9-based fungal strain editing …
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