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Rosacea
Publication Year: 2025 Source: StatPearls PMID: 32491506
Rosacea is a common chronic inflammatory disease that presents with recurrent flushing, erythema, telangiectasia, papules, or pustules on nose, chin, cheeks, and forehead. There are four clinical subtypes of rosacea based on the predominant signs and symptoms: erythematotelangiectatic, papulopustular, phymatous, and ocular. The subtypes are not mutually exclusive. Patients can …
HLA-B27 Syndromes
Publication Year: 2025 Source: StatPearls PMID: 31855367
The correlation between the presence of HLA-B27 and ankylosing spondylitis has been a known entity since the early 1970s. Although common in the general population, this allele strongly contributes to the susceptibility of development of the linked family of inflammatory rheumatologic conditions collectively known as spondyloarthritis. Additional associated diseases, particularly …
Epidermolysis Bullosa Acquisita
Publication Year: 2025 Source: StatPearls PMID: 32119399
Epidermolysis bullosa acquisita (EBA) is a rare, chronic autoimmune blistering disease that impacts both the skin and mucous membranes. This condition arises due to autoantibodies targeting type VII collagen-a crucial component of anchoring fibrils within the dermal-epidermal junction (DEJ). These anchoring fibrils are responsible for attaching the epidermis to the …
Indium-111 White Blood Cell Scan
Publication Year: 2025 Source: StatPearls PMID: 32119443
Indium-111 (In-111)-labeled white blood cell (WBC) scintigraphy is a nuclear medicine imaging modality used to diagnose occult infections, especially when other imaging techniques are contraindicated or uninformative. This technique leverages the fundamental biological process in which labeled leukocytes migrate to and accumulate at sites of inflammation, which can then be …
Chronic Pelvic Pain
Publication Year: 2025 Source: StatPearls PMID: 32119472
Chronic pelvic pain is a persistent, disabling, or cyclic intermittent pain within the pelvis, most commonly affecting women. Although chronic pelvic pain in men is less prevalent, it exists with a distinct set of overlapping comorbidities. Chronic pelvic pain is often associated with conditions such as irritable bowel syndrome (IBS), …
Pericholangitis
Publication Year: 2025 Source: StatPearls PMID: 31985931
Primary sclerosing cholangitis (PSC) is an uncommon cholestatic liver disease characterized by the inflammation and fibrosis of intra- and extra-hepatic biliary ducts. It has an incidence of 0.9 to 1.3 cases per 100000 in the United States. After recruiting of endoscopic retrograde cholangiopancreatography (ERCP) in the early 1970s, it revealed …
Histology, Goblet Cells
Publication Year: 2025 Source: StatPearls PMID: 31985989
Goblet cells arise from pluripotent stem cells and derive their name from their goblet, cup-like appearance (see Image. Histology Showing Goblet Cells). The primary function of goblet cells is to secrete mucin and create a protective mucus layer. Goblet cells are also thought to be involved with immunoregulation. Samples of …
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