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Glucagon-Like Peptide 1 Receptor Agonists Are Not Associated With an Increased Risk of Ileus or Intestinal Obstruction in Patients with Inflammatory Bowel Disease-A Danish Nationwide Cohort Study
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 39603814 DOI: 10.1093/ibd/izae276
BACKGROUND: There is a global increase in the prevalence of obesity, including among individuals with inflammatory bowel disease (IBD). Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are potential anti-obesity medications due to their weight-lowering effects. However, concerns exist regarding ileus and intestinal obstruction as a severe side effect. METHODS: This nationwide …
Letter to the Editor 'Relationship Between Social Isolation, Loneliness and Psychological Well-Being in Inflammatory Bowel Disease Patients: The Mediating Role of Disease Activity Social Isolation in Inflammatory Bowel Disease'
Publication Year: 2024 Source: J Clin Nurs PMID: 39604011
No Abstract
Evaluating the Anti-inflammatory Efficacy of a Novel Bipyrazole Derivative in Alleviating Symptoms of Experimental Colitis
Publication Year: 2024 Source: Curr Mol Pharmacol PMID: 39604158 DOI: 10.2174/0118761429333261241021034043
AIMS: This aims to assess the efficacy of 2', 3, 3, 5'-Tetramethyl-4'-nitro-2'H-1, 3'-bipyrazole (TMNB), a novel compound, in colitis treatment. BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with limited effective treatments available. The exploration of new therapeutic agents is critical for advancing treatment …
Multi-biome analysis identifies distinct gut microbial signatures and their crosstalk in ulcerative colitis and Crohn's disease
Publication Year: 2024 Source: Nat Commun PMID: 39604394
No Abstract
Fungal symbiont transmitted by free-living mice promotes type 2 immunity
Publication Year: 2024 Source: Nature PMID: 39604728
No Abstract
Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks
Publication Year: 2024 Source: bioRxiv PMID: 39605355 DOI: 10.1101/2024.11.11.623014
BACKGROUND & AIMS: Imaging-based, single-cell spatial transcriptomics (iSCST) using formalin-fixed, paraffin-embedded (FFPE) tissue could transform translational research by retaining all tissue cell subsets and spatial locations while enabling the analysis of archived specimens. We aimed to develop a robust framework for applying iSCST to archived clinical FFPE mucosal biopsies from …
Non-invasive vagus nerve stimulation in anti-inflammatory therapy: mechanistic insights and future perspectives
Publication Year: 2024 Source: Front Neurosci PMID: 39605787
No Abstract
Glucagon-like peptide-1 receptor agonists and the risk of erectile dysfunction: a drug target Mendelian randomization study
Publication Year: 2024 Source: Front Endocrinol (Lausanne) PMID: 39605940
No Abstract
Metabolic stress in patients with acute severe ulcerative colitis - a single-center cohort study
Publication Year: 2024 Source: Front Endocrinol (Lausanne) PMID: 39605944
No Abstract
Microscopic messengers: microbiota-derived bacterial extracellular vesicles in inflammatory bowel disease
Publication Year: 2024 Source: Front Microbiol PMID: 39606115 DOI: 10.3389/fmicb.2024.1481496
Inflammatory bowel disease (IBD) is a persistent and complex condition accomplished by inflammation of the gastrointestinal system, encompassing Crohn's disease (CD) and ulcerative colitis (UC). This condition is caused by the combination of genetic predispositions, environmental triggers, and dysregulated immunological responses, which complicates diagnosis and treatment. The latest developments in …
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