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Trichinella spiralis adult excretory-secretory antigen promotes peripheral regulatory T cell differentiation and attenuates experimental colitis via TGF-β-like mechanisms
Publication Year: 2025 Source: Parasit Vectors PMID: 40597393
BACKGROUND: Trichinella spiralis adult excretory-secretory antigen (TsAES) has been proposed as a potential immunomodulator capable of promoting naive T cell differentiation into peripheral regulatory T cells (pTregs). This study aims to investigate the effects of TsAES on pTreg development and evaluate its role in alleviating dextran sulfate sodium (DSS)-induced acute …
Identification and experimental validation of ulcerative colitis-associated hub genes through integrated WGCNA and lysosomal autophagy analysis
Publication Year: 2025 Source: Hum Genomics PMID: 40597456
OBJECTIVE: This study aims to systematically identify differentially expressed genes associated with lysosomal autophagy in ulcerative colitis (UC) and validate key candidate genes in an animal model, thereby providing novel insights driving UC pathogenesis. METHODS: The GSE47908 dataset from the Gene Expression Omnibus (GEO) was subjected to principal component analysis …
Infliximab for patients with moderate to severely active ulcerative colitis: an updated meta-analysis of randomized controlled trials
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40597681
BACKGROUND AND AIMS: Ulcerative colitis (UC) is a serious inflammatory bowel disease with significant morbidity and mortality. Infliximab (IFX), a TNF-alpha antagonist, is recommended by the American Gastroenterological Association, but its clinical effectiveness and safety are based on limited studies. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy …
Unveiling the diagnostic and pro-inflammatory role of crohn's disease: insights from 16 S-guided discovery and species-specific validation
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40597688
BACKGROUND: The rising incidence of Crohn's disease (CD) in Asia underscores the need to explore its underlying mechanisms. The interaction between gut microbiota and the host is strongly linked to CD onset and progression, yet the precise mechanisms remain unclear. Previous studies have demonstrated that Ruminococcus gnavus (R. gnavus) is …
Routine psychological problems screening in hospitalized inflammatory bowel diseases and its effect for progression-free survival from disease worsening
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40597694
BACKGROUND: To examine the progression-free survival from disease worsening after the implementation of routine screening for psychological problems in hospitalized patients with inflammatory bowel diseases (IBDs) during a long-term follow-up. METHODS: The retrospective cohort study enrolled 1265 patients with active IBDs. Their records were stratified into screening cohort (n = …
The experiences of fertility concerns in women with inflammatory bowel disease of childbearing age: a descriptive qualitative study
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40597726 DOI: 10.1186/s12876-025-04046-z
BACKGROUND: Since the onset of inflammatory bowel disease (IBD) symptoms among females is usually in the reproductive years, issues regarding pregnancy and childbearing are prevalent. Relatively few studies have focused on the fertility concerns of women with IBD. PURPOSE: To comprehensively explore the fertility concerns of women with IBD. PATIENTS …
Pain and Sedative Medication Use Among Individuals With Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40599116 DOI: 10.1111/apt.70247
BACKGROUND: Individuals with inflammatory bowel disease (IBD) often experience pain, mood disturbances, and sleep disruption, which may lead to greater use of pain-relieving and sedative medications compared with the general population. These are associated with increased mortality, paradoxical worsening of pain, and inappropriate IBD treatment discontinuation. Chronic prescribing and co-prescribing …
Revolutionizing gastroenterology and hepatology with artificial intelligence: From precision diagnosis to equitable healthcare through interdisciplinary practice
Publication Year: 2025 Source: World J Gastroenterol PMID: 40599184
Artificial intelligence (AI) is driving a paradigm shift in gastroenterology and hepatology by delivering cutting-edge tools for disease screening, diagnosis, treatment, and prognostic management. Through deep learning, radiomics, and multimodal data integration, AI has achieved diagnostic parity with expert clinicians in endoscopic image analysis (e.g., early gastric cancer detection, colorectal …
Cardiometabolic diseases in patients with inflammatory bowel disease: An evidence-based review
Publication Year: 2025 Source: World J Gastroenterol PMID: 40599191 DOI: 10.3748/wjg.v31.i24.107661
Metabolic syndrome-comprising central adiposity, dyslipidaemia, insulin resistance, and hypertension-is a major risk factor for cardiometabolic diseases such as ischaemic heart disease, stroke, and type 2 diabetes. Its global prevalence is rising, largely driven by urbanization, sedentary lifestyles, and dietary changes. These same factors are also associated with the increasing incidence …
Small Bowel Stricture in a Crohn's Patient: An Unrelated Etiology
Publication Year: 2025 Source: Case Rep Gastrointest Med PMID: 40599252
Small bowel strictures are a common complication of Crohn's disease (CD), which can lead to obstruction, perforation, and fistula formation. However, strictures can stem from other etiologies in CD patients, including malignancy, prior surgery, radiation, and ischemia. We present a patient who developed a new long-segment jejunal and ileal stricture …
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