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Bile acid receptors regulate the role of intestinal macrophages in inflammatory bowel disease

Publication Year: 2025 Source: Front Immunol PMID: 40599770 DOI: 10.3389/fimmu.2025.1577000

Many factors, including genetic vulnerability, barrier function, intestinal immune cells, and intestinal microbiota, may combine to affect the occurrence and progression of inflammatory bowel disease (IBD). Through targeting bile acid receptors (BARs), bile acids have been demonstrated to have a range of regulatory effects on intestinal immune responses in recent …

The microbiome of pseudomyxoma peritonei: a scoping review

Publication Year: 2025 Source: Pleura Peritoneum PMID: 40599846

There is growing interest in the role of the microbiome in carcinogenesis, but few studies examine the microbiome of pseudomyxoma peritonei (PMP). This scoping review summarises the microorganisms identified in PMP samples and examines the evidence of their role in disease outcomes. The methodology was developed in accordance with the …

Association Between Caffeine Intake and Bowel Habits and Inflammatory Bowel Disease: A Population-Based Study

Publication Year: 2025 Source: J Multidiscip Healthc PMID: 40600201 DOI: 10.2147/JMDH.S512855

BACKGROUND: The effect of caffeine in coffee, a popular beverage, on gastrointestinal symptoms has been the subject of ongoing debate worldwide. The present study explored the association between caffeine intake and bowel habits and Inflammatory bowel disease (IBD). METHODS: Data from the National Health and Nutrition Examination Survey (NHANES) spanning …

Cheese starter cultures attenuate inflammation in the in vitro Caco-2 model

Publication Year: 2025 Source: AIMS Microbiol PMID: 40600210 DOI: 10.3934/microbiol.2025017

Chronic inflammation is identified to be an underlying pathophysiology in different conditions including inflammatory bowel disease (IBD). Since the aberrant interaction of the mucosal immune system with the dysbiotic flora has been reported to contribute to IBD development, probiotics have been studied for potential prophylaxis and treatment. In this regard, …

Tissue-adhesive, antibacterial, and macrophage-reprogramming hydrogel for sealing colorectal anastomotic leakage and promoting healing

Publication Year: 2025 Source: J Mater Chem B PMID: 40600336

Intestinal anastomosis is indispensable for treating inflammatory bowel disease and colorectal cancer, yet anastomotic leakage (AL) remains a frequent, life-threatening complication that markedly prolongs hospitalization. Conventional suturing affords limited protection against leakage and infection. Here, we report an injectable, multifunctional hydrogel (PGOT) composed of gamma-poly(glutamic acid) conjugated with L-cysteine and …

Ecological Momentary Assessment of the Quality of Life and Self-Efficacy Among People With a Stoma: Longitudinal Study

Publication Year: 2025 Source: J Med Internet Res PMID: 40600935

BACKGROUND: When a stoma is formed, people with a stoma have to adjust to managing this on a daily basis. There are a number of factors that can impact their self-efficacy to self-manage and their quality of life, including complications with their stoma, body image concerns, stigma, and the changes …

Metformin use and risk of colorectal cancer in patients with inflammatory bowel disease: a nationwide, Population-Based cohort study

Publication Year: 2025 Source: J Natl Cancer Inst PMID: 40601368 DOI: 10.1093/jnci/djaf165

BACKGROUND: Patients with inflammatory bowel disease (IBD) have a significantly elevated risk of colorectal cancer (CRC). While metformin has been associated with lower CRC risk in general diabetic populations, its effect in patients with coexisting IBD and diabetes-a group at compounded risk-remains unclear. METHODS: We conducted a nationwide cohort study …

Psychosocial care needs of emerging adults with inflammatory bowel disease

Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 40601393 DOI: 10.1080/17474124.2025.2529208

INTRODUCTION: Inflammatory bowel disease (IBD) is a life-long illness that is increasing in prevalence and incidence, disproportionately amongst young adults. The diagnosis often coincides with emerging adulthood, a critical developmental stage when young adults face formative life changes such as independent living, finalization of education and career path, redefining relationships …

Prescribing Inflammatory Bowel Disease Medications in Chronic Kidney Disease: A Practical Guide

Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40601470 DOI: 10.1111/apt.70262

BACKGROUND: The prevalence of chronic kidney disease (CKD) in patients with inflammatory bowel disease (IBD) is increasing. The pharmacokinetic profiles of IBD medications in patients with advanced-stage CKD are not well studied. AIM: To provide evidence-based guidance on the use of medical therapies in patients with IBD and CKD. METHODS: …

Type D personality, insomnia severity, perceived stress, and health-related quality of life in inflammatory bowel disease: A case-control study

Publication Year: 2025 Source: J Psychosom Res PMID: 40602127 DOI: 10.1016/j.jpsychores.2025.112199

BACKGROUND: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is associated with significant psychological distress. This study aimed to investigate the relationships between Type D personality, insomnia severity, and perceived stress in IBD patients and a matched control group. METHODS: A case-control study was conducted …

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