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Leucine and glutamic acid attenuate the dextran sulfate sodium-induced colitis in mice by modulating the inflammatory response and energy metabolism processes
Publication Year: 2025 Source: J Nutr Biochem PMID: 40602551 DOI: 10.1016/j.jnutbio.2025.110016
Ulcerative colitis, a multifactorial chronic condition of the gastrointestinal tract, has seen increasing interest in dietary intervention as part of its treatment strategy. In this study, we utilized a Dextran Sodium Sulfate (DSS)-induced acute colitis mouse model to assess the impact of leucine and glutamic acid on mucosal ulceration, inflammatory …
Legume seed coat polysaccharides: Extraction, physicochemical properties, and anti-inflammatory potential against intestinal inflammation-A review
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40602564 DOI: 10.1016/j.ijbiomac.2025.145662
Intestinal inflammation refers to the inflammatory response in the intestines due to various causes, encompassing conditions such as infectious enteritis, inflammatory bowel disease (IBD), and irritable bowel syndrome (IBS). These disorders pose significant public health challenges, in severe cases, may lead to complications such as colon cancer. Legumes are integral …
Impact of transforming growth factor-β2 enriched food for special medical purposes on nutritional status, microbiota and clinical outcomes after allogeneic hematopoietic stem cell transplantation: prospective analysis of 192 consecutive patients
Publication Year: 2025 Source: Clin Nutr ESPEN PMID: 40602606
BACKGROUND AND AIMS: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents an essential treatment for various diseases despite being burdened by severe malnutrition, serious infections, graft-versus-host disease (GVHD) and gut microbiota dysbiosis. There is growing evidence suggesting that nutritional interventions may potentially lower these risks. In particular, nutritional supports enriched with …
Crohn's disease and ulcerative colitis exhibit prediagnostic antibody signatures with shared and divergent changes towards disease onset
Publication Year: 2025 Source: Gut PMID: 40602996 DOI: 10.1136/gutjnl-2024-334362
BACKGROUND: The development of IBD is known to involve early immunological alterations, but our understanding of the changes in antibody epitope repertoires moving from the prediagnostic phase towards disease onset remains incomplete. OBJECTIVE: In this study, we comprehensively characterised systemic antibody responses in patients with IBD before and after disease …
Moderating effects of resilience and depression on social support and life satisfaction in patients with IBD: a cross-sectional study
Publication Year: 2025 Source: Sci Rep PMID: 40603424 DOI: 10.1038/s41598-025-06221-4
Inflammatory bowel disease (IBD) significantly impaired patients' quality of life and might have affected their life satisfaction. Based on the psychosocial stress model and the conservation of resources theory, this study aimed to investigate the level of life satisfaction among patients with IBD and explored the relationships among social support, …
Etiological mechanisms underlying the hazard factors and inflammatory bowel disease: a prospective cohort study
Publication Year: 2025 Source: Sci Rep PMID: 40603574 DOI: 10.1038/s41598-025-08744-2
Inflammatory bowel disease (IBD) is a progressively advancing immune-mediated disorder characterized by intricate pathophysiological features. Despite extensive research, the mechanisms linking various risk factors to the development of IBD remain incompletely understood. We conducted analyses within a prospective cohort of unrelated European individuals, utilizing data from the UK Biobank. This …
Immune-Mediated Disorders in Patients With Alopecia Areata: Systematic Review and Meta-Analysis
Publication Year: 2025 Source: Int J Dermatol PMID: 40603702
Alopecia areata (AA) is a nonscarring, organ-specific autoimmune disorder characterized by hair loss. Emerging evidence suggests that AA frequently coexists with other immune-mediated diseases, but the strength and consistency of these associations remain unclear. This meta-analysis aimed to systematically evaluate the prevalence and risk of immune-mediated comorbidities in patients with …
An Updated Meta-analysis of Pancreatic Cancer Risk in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: J Gastrointest Cancer PMID: 40603749 DOI: 10.1007/s12029-025-01266-0
OBJECTIVE: This meta-analysis aims to systematically evaluate the relationship between inflammatory bowel disease (IBD) and the risk of developing pancreatic cancer (PC). DESIGN: Systematic review and meta-analysis. METHOD: We searched PubMed (Medline), Web of Science, and Scopus up until September 8, 2024. To evaluate heterogeneity among the studies, we used …
Expert consensus on diagnostic guidelines for pediatric inflammatory bowel disease in Japan
Publication Year: 2025 Source: J Gastroenterol PMID: 40603758 DOI: 10.1007/s00535-025-02271-7
BACKGROUND: Inflammatory bowel disease (IBD) can occur at any age. In pediatric patients, the disease may present with a broader range of symptoms and more severe course than in adults, due to ongoing growth and development. Therefore, pediatric IBD often exhibits an atypical clinical course and laboratory findings. It is …
Therapeutic mechanisms of exclusive enteral nutrition in Crohn's disease
Publication Year: 2025 Source: Semin Immunopathol PMID: 40603760
Crohn's disease (CD) is a chronic, relapsing multifactorial inflammatory condition of the gastrointestinal tract, which is diagnosed under the age of 17 in 25% of patients, categorized as pediatric CD (pCD). Exclusive enteral nutrition (EEN) is a first-line therapy for inducing remission in pCD, yet its precise mechanisms remain poorly …
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