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Iron and the Intestinal Microbiome
Publication Year: 2025 Source: Adv Exp Med Biol PMID: 40603801
Iron in the gut is like a double-edged sword. On one side, it is essential for numerous physiological processes, including oxygen transport and energy production, and is crucial for addressing conditions like anemia. However, on the other side, excess or unabsorbed iron can disrupt gut homeostasis, fuel harmful pathogens, contribute …
Kurarinone Alleviates cGAS-STING-Triggered Inflammatory Diseases by Targeting STING
Publication Year: 2025 Source: Phytother Res PMID: 40604353
Aberrant activation of the cGAS-STING pathway has been implicated in the pathogenesis of diverse inflammatory diseases. Kurarinone, a flavonoid compound isolated from Sophorae tonkinensis Radix et Rhizoma, has been reported to exhibit anti-inflammatory effects and is used to treat inflammatory diseases. But the effect of kurarinone on the cGAS-STING pathway …
Varying patterns of risk factors for inflammatory bowel disease in the East and the West: insights from the global burden of disease study 2021
Publication Year: 2025 Source: BMC Public Health PMID: 40604809
BACKGROUND: Certain risk factors for inflammatory bowel disease (IBD) have not been thoroughly examined. The disparity in IBD risk factors between Eastern and Western regions remains inadequately understood. This study seeks to comprehensively investigate global IBD risk factors and delineate the differences between Eastern and Western populations. METHODS: The global …
Gut sensory neurons as regulators of neuro-immune-microbial interactions: from molecular mechanisms to precision therapy for IBD/IBS
Publication Year: 2025 Source: J Neuroinflammation PMID: 40605050
As potentially important biosensors within the intestinal mucosal barrier, gut sensory neurons appear to dynamically orchestrate tissue homeostasis through multimodal integration of mechanical forces, chemical cues, and microbial metabolites. While current research indicates gut sensory neurons may play a significant role in the pathophysiology of IBD/IBS, the precise etiological mechanisms …
Structural Model of the Oncostatin M (OSM)-OSMRβ-gp130 Ternary Complex Reveals Pathways of Allosteric Communication in OSM Signaling
Publication Year: 2025 Source: Curr Med Chem PMID: 40605163
INTRODUCTION: Human oncostatin M (OSM) is a pleiotropic cytokine that regulates inflammatory and immune responses by binding to the heterodimer receptor complex OSM receptor beta (OSMRbeta) and glycoprotein 130 (gp130). The distinct signaling pathways triggered by OSM are involved in multiple chronic inflammatory conditions, such as inflammatory bowel disease (IBD), …
[Heat shock protein family A member 5 regulation of ferroptosis alleviates acute-phase mucosal injury in ulcerative colitis]
Publication Year: 2025 Source: Zhonghua Nei Ke Za Zhi PMID: 40605290
Objective: This study aimed to investigate the role of heat shock protein family A member 5 (HSPA5) in ferroptosis at its regulatory mechanisms in ulcerative colitis (UC), using both a dextran sulfate sodium (DSS)-induced mouse model of acute colitis and in vitro cell experiments. Methods: Differentially expressed genes in UC …
Harnessing the Immunomodulation of UV-Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40605511
Sunbathing excessively heightens the risk of skin carcinogenesis due to ultraviolet (UV)-mediated immunosuppression. Keratinocytes, the primary cells in epidermis, play a pivotal role in orchestrating the UV-induced immunosuppressive response by releasing platelet-activating factor (PAF) upon UV exposure. Adopting a paradigm shift that transforms a known health hazard as a potential …
An Interpretable Artificial Intelligence System for Crohn's Disease Ulcer Identification and Grading on Double-Balloon Enteroscopy Images
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40605587
BACKGROUND: Crohn's disease (CD) is an incurable inflammatory bowel disease that can lead to a variety of complications and requires lifelong treatment. However, the diagnosis and management of Crohn's disease exhibit high rates of misdiagnosis and missed diagnoses, along with significant variability, among primary care facilities and novice endoscopists. Therefore, …
[Pouchitis]
Publication Year: 2025 Source: Ugeskr Laeger PMID: 40605597
Pouchitis is the most common complication following ileal pouch-anal anastomosis. It is characterized by pouch inflammation and symptoms resembling ulcerative colitis. The aetiology is thought to involve a combination of genetic factors, a dysregulated immune response, and alterations in the gut microbiome. Pouchitis is classified as acute if symptoms less-than …
Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phospholipase A2
Publication Year: 2025 Source: Genes Dis PMID: 40605975
Ulcerative colitis is an idiopathic, chronic inflammatory bowel disease. Its pathogenesis is multifactorial involving inflammation and immune dysregulation. Proinflammatory TNFalpha/NFkappaB signaling is believed to play a cardinal role in ulcerative colitis. Growing evidence indicates the molecular interactions between the cellular metabolites and different phases of inflammation. This study aims to …
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