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The Emerging Roles of the Stress Epigenetic Reader LEDGF/p75 in Cancer Biology and Therapy Resistance: Mechanisms and Targeting Opportunities
Publication Year: 2024 Source: Cancers (Basel) PMID: 39682146 DOI: 10.3390/cancers16233957
The lens epithelium derived growth factor of 75 kD (LEDGF/p75) is a transcription co-activator and epigenetic reader that has emerged as a stress oncoprotein in multiple human cancers. Growing evidence indicates that it promotes tumor cell survival against certain therapeutic drugs. The amino (N)-terminal region of LEDGF/p75 contains a PWWP …
Circulating Hepcidin Levels Are an Independent Predictor of Survival in Microsatellite Stable Metastatic Colorectal Cancer Patient Candidates for Standard First-Line Treatment
Publication Year: 2024 Source: Cancers (Basel) PMID: 39682164
No Abstract
Hepcidin Is a Valuable Therapeutic Target for Colorectal Cancer
Publication Year: 2024 Source: Cancers (Basel) PMID: 39682254
No Abstract
Infectious Bursal Disease Virus in Algeria: Persistent Circulation of Very Virulent Strains in Spite of Control Efforts
Publication Year: 2024 Source: Animals (Basel) PMID: 39682508 DOI: 10.3390/ani14233543
Infectious bursal disease (IBD) is among the most impactful immunosuppressive diseases of poultry. Its agent, infectious bursal disease virus (IBDV), is prone to both mutation and reassortment, resulting in a remarkable variability. Traditionally, IBDV characterization relies on antigenicity and pathogenicity assessment, but multiple phylogenetic classifications have been recently proposed, whose …
Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa
Publication Year: 2024 Source: Cells PMID: 39682729 DOI: 10.3390/cells13231981
Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous cellular processes, such as cell growth, inflammation, differentiation, immune-mediated responses and oncogenic transformation. The aim of this review is to review the literature concerning the role of several PTPs-PTPN22, PTPN2, PTPN6, PTPN11, PTPsigma, DUSP2, DUSP6 and PTPRK-at the …
Comprehensive Assessment of Cannabidiol and HU308 in Acute and Chronic Colitis Models: Efficacy, Safety, and Mechanistic Innovations
Publication Year: 2024 Source: Cells PMID: 39682761 DOI: 10.3390/cells13232013
Cannabinoids are emerging as promising treatments for inflammatory diseases such as ulcerative colitis. Specifically, cannabinoid 2 (CB2) receptors, which are upregulated during inflammation, have been distinctively linked to anti-inflammatory and analgesic effects. HU308, a synthetic cannabinoid developed to activate CB2 receptors selectively, aims to minimize unwanted off-target side effects. This …
The Influence and Mechanisms of Natural Plant Polysaccharides on Intestinal Microbiota-Mediated Metabolic Disorders
Publication Year: 2024 Source: Foods PMID: 39682954
No Abstract
The Bacteriocins Produced by Lactic Acid Bacteria and the Promising Applications in Promoting Gastrointestinal Health
Publication Year: 2024 Source: Foods PMID: 39682959
No Abstract
Prevalence, Risk Factors and Association with Clinical Outcomes of Malnutrition and Sarcopenia in Inflammatory Bowel Disease: A Prospective Study
Publication Year: 2024 Source: Nutrients PMID: 39683376 DOI: 10.3390/nu16233983
No Abstract
Using Participatory Narrative Inquiry to Assess Experiences and Self-Experimentation with Diet Interventions in Inflammatory Bowel Disease Patients
Publication Year: 2024 Source: Nutrients PMID: 39683421 DOI: 10.3390/nu16234027
BACKGROUND AND AIMS: To improve quality of life (QoL), patients with inflammatory bowel diseases (Crohn's disease and ulcerative colitis) often self-experiment with lifestyle changes such as dietary modifications. The nature (e.g., type of interventions, expectations, perceived efficacy) of these single-subject experiments has not been systematically investigated. METHOD: We used Participatory …
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