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Insights into Microbiota-Host Crosstalk in the Intestinal Diseases Mediated by Extracellular Vesicles and Their Encapsulated MicroRNAs
Publication Year: 2024 Source: Int J Mol Sci PMID: 39684711
No Abstract
Fibroblast Heterogeneity in Inflammatory Bowel Disease
Publication Year: 2024 Source: Int J Mol Sci PMID: 39684719 DOI: 10.3390/ijms252313008
Intestinal fibroblasts are pivotal players in maintaining tissue homeostasis and orchestrating responses to injury and inflammation within the gastrointestinal (GI) tract. Fibroblasts contribute significantly to the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis (UC), by secreting pro-inflammatory cytokines, modulating immune cell activity, and promoting fibrosis. …
Inflammasomes in Intestinal Disease: Mechanisms of Activation and Therapeutic Strategies
Publication Year: 2024 Source: Int J Mol Sci PMID: 39684769 DOI: 10.3390/ijms252313058
NOD-like receptors (NLRs) are a family of cytosolic pattern recognition receptors (PRRs) implicated in the innate immune sensing of pathogens and damage signals. NLRs act as sensors in multi-protein complexes called inflammasomes. Inflammasome activity is necessary for the maintenance of intestinal homeostasis, although their aberrant activation contributes to the pathogenesis …
AhR-Induced Anti-Inflammatory Effects on a Caco-2/THP-1 Co-Culture Model of Intestinal Inflammation Are Mediated by PPARγ
Publication Year: 2024 Source: Int J Mol Sci PMID: 39684781
No Abstract
Therapeutic Efficacy and Underlying Mechanisms of a Mannoglucan from Hirsutella sinensis Mycelium on Dextran Sulfate Sodium-Induced Inflammatory Bowel Disease in Mice: Modulation of the Intestinal Barrier, Oxidative Stress and Gut Microbiota
Publication Year: 2024 Source: Int J Mol Sci PMID: 39684811
No Abstract
Investigating the Immunomodulatory Impact of Fecal Bacterial Membrane Vesicles and Their IgA Coating Patterns in Crohn's Disease Patients
Publication Year: 2024 Source: Int J Mol Sci PMID: 39684904
No Abstract
Optimal Management of Patients with Moderate-to-Severe Inflammatory Bowel Disease
Publication Year: 2024 Source: J Clin Med PMID: 39685485 DOI: 10.3390/jcm13237026
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and often debilitating condition requiring complex and individualized management. Over the past few decades, advancements in understanding IBD pathophysiology have led to a transformative shift in therapeutic approaches. This article provides a comprehensive overview of …
The Challenges in Treating Inflammatory Bowel Diseases During the COVID-19 Pandemic: An Opinion
Publication Year: 2024 Source: J Clin Med PMID: 39685586 DOI: 10.3390/jcm13237128
The COVID-19 pandemic posed significant challenges in the treatment of chronic diseases, particularly inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis. These challenges are multifaceted, encompassing difficulties in maintaining routine care, concerns about the safety of immunosuppressive therapies, disruptions in healthcare delivery, and the complexities of managing …
A Cross-Sectional Evaluation of Disability in Inflammatory Bowel Disease Using IBD Disk in a Tertiary Center from Romania
Publication Year: 2024 Source: J Clin Med PMID: 39685627 DOI: 10.3390/jcm13237168
Background/Objectives: The management of inflammatory bowel disease (IBD) includes, besides the control of symptoms, the prevention of organ damage and the improvement of the overall disability. Methods: A single-centered, cross-sectional, non-interventional and population-based study was conducted between October 2023 and August 2024 in the Department of Internal Medicine 2 and …
Efficacy and Safety of Janus Kinase-Inhibitors in Ulcerative Colitis
Publication Year: 2024 Source: J Clin Med PMID: 39685645 DOI: 10.3390/jcm13237186
Background: Janus kinase-inhibitors (JAK-i) have recently been approved for treating patients with Ulcerative Colitis (UC); therefore, further information is needed, particularly regarding efficacy and safety. Objectives: To provide a comprehensive review regarding the efficacy and safety of currently available JAK-i in UC. Methods: The PubMed and Scopus databases were considered, …
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