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Transforming pediatric imaging: The role of four-dimensional flow magnetic resonance imaging in quantifying mesenteric blood flow
Publication Year: 2025 Source: World J Radiol PMID: 40606042
The article "Assessment of superior mesenteric vascular flow quantitation in children using four-dimensional flow magnetic resonance imaging" suggests to use of four-dimensional (4D) flow magnetic resonance imaging (MRI) which is also to measure the blood flow in the superior mesenteric vein (SMV) in pediatric patients over the traditional method. The …
Patient Perspective and Worry regarding Ulcerative Colitis-Associated Cancer: A Questionnaire-Based Surveillance Study
Publication Year: 2025 Source: Inflamm Intest Dis PMID: 40606436
INTRODUCTION: Patients with ulcerative colitis are prone to mental disorders and may be under psychological burden due to the development of ulcerative colitis-associated cancer. Therefore, evidence regarding awareness and concerns about cancer development is needed. We aimed to investigate the state of awareness regarding cancer in patients with ulcerative colitis, …
Mild Chronic Colitis Exacerbates Intracerebral Inflammation in Mice with Parkinson's Disease Through LRRK2-Mediated Regulation of NF-κB Activation and Inhibition of Nrf2
Publication Year: 2025 Source: J Inflamm Res PMID: 40606593
BACKGROUND AND OBJECTIVE: Inflammatory bowel disease (IBD) is a known risk factor for Parkinson's disease (PD). Leucine-rich repeat kinase 2 (LRRK2), a protein associated with both disease, regulates inflammation in the colon and brain. However, the precise mechanism by which LRRK2 mediates the crosstalk between intestinal inflammation and PD neuropathology …
Innovative pH-responsive alginate-coated rosuvastatin-loaded chitosan nanoparticles: a targeted approach to inhibiting HMGB1-activated RAGE/TLR4-NFκB signaling in colonic inflammation in rats
Publication Year: 2025 Source: Front Pharmacol PMID: 40606616
This study developed and optimized an innovative oral pH-dependent drug delivery system utilizing rosuvastatin-loaded chitosan nanoparticles (RSV-CSNPs) coated with sodium alginate (ALG). The goal was to protect RSV-CSNPs from degradation in the acidic gastric environment and facilitate targeted sustained release in the colon to address inflammatory bowel disease. Nanoparticles were …
Different perceptions on the diagnosis and treatment of Crohn's disease between patients and gastroenterologists: a multicenter retrospective study
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40607168
BACKGROUND: Physician assessments of patient symptoms may not align with the patients' subjective experiences, potentially affecting disease management. The key drivers of patients with Crohn's disease (CD) regarding their physicians' engagement in treatment decision-making are unknown. OBJECTIVE: This study aimed to compare cognitive differences between patients and gastroenterologists in the …
ER stress genes (COL1A1, LOXL2, VWF) predicts IKK-16 as a Candidate therapeutic target for colitis-related inflammation and fibrosis suppression
Publication Year: 2025 Source: Front Immunol PMID: 40607383
INTRODUCTION: The role of endoplasmic reticulum stress (ERS) in the immune-inflammatory dysregulation and intestinal fibrosis associated with ulcerative colitis (UC) remains unclear. This study aims to identify ERS-related genes involved in UC fibrosis and explore potential therapeutic targets. METHODS: Differentially expressed ERS-related genes (DE-ERGs) were identified through comprehensive analysis of …
Exploring Inflammatory Bowel Disease Discourse on Reddit Throughout the COVID-19 Pandemic Using OpenAI's GPT-3.5 Turbo Model: Classification Model Validation and Case Study
Publication Year: 2025 Source: J Med Internet Res PMID: 40607732
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic autoimmune disorder with an increasing prevalence in the general population. Internet-based communities have become vital for communication among patients with IBD, especially throughout the COVID-19 pandemic. However, these internet-based patient-to-patient communications remain largely underexplored. OBJECTIVE: This study aims to analyze community posts …
Bidirectional Risk Association Between Hidradenitis Suppurativa and Inflammatory Bowel Disease
Publication Year: 2025 Source: Acta Derm Venereol PMID: 40607836
Hidradenitis suppurativa is an inflammatory skin disease of the pilosebaceous unit encompassing painful, recurrent, and malodorous abscesses, inflammatory nodules, dermal sinus tracts, and cicatrices. Hidradenitis suppurativa has been linked to several comorbidities, including inflammatory bowel disease, though evidence is limited by small sample sizes and possible bidirectional associations remain uncertain. …
Examining miR-196a, miR-196b and NF-κBIα gene expression in colitis mice model
Publication Year: 2025 Source: AMB Express PMID: 40608248
Bifidobacterium bifidum (B. bifidum) anti-inflammatory characteristics and ability to modify the gut microbiota make it a promising treatment option for Inflammatory Bowel Disease (IBD). The present study investigated the modulatory effects of B. bifidum on the expression of miR-196a, miR-196b, and NF-kappaBIalpha genes in a DSS-induced IBD mice model. Thirty …
Hyperactivated Interferon-gamma Pathways in Perianal Fistulizing Crohn's Disease by Single-Cell and Spatial Multi-omics
Publication Year: 2025 Source: J Clin Invest PMID: 40608410
Perianal fistulizing Crohn's disease (PCD) is a common and debilitating complication with elusive pathophysiology. To define actionable immunologic targets in PCD, we recruited patients with PCD (n = 24), CD without perianal disease (NPCD, n = 10), and idiopathic/cryptoglandular perianal fistulas (IPF, n = 29). Biopsies from fistula tracts, fistula …
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