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Creeping fat in Crohn's disease: an immunometabolic imbalance worth targeting?
Publication Year: 2025 Source: J Crohns Colitis PMID: 40608412
No Abstract
Understanding disease-associated metabolic changes in human colonic epithelial cells using the iColonEpithelium metabolic reconstruction
Publication Year: 2025 Source: PLoS Comput Biol PMID: 40609069
The colonic epithelium plays a key role in the host-microbiome interactions, allowing uptake of various nutrients and driving important metabolic processes. To unravel detailed metabolic activities in the human colonic epithelium, our present study focuses on the generation of the first cell-type-specific genome-scale metabolic model (GEM) of human colonic epithelial …
Propionate alleviated colitis by modulating iron homeostasis to inhibit ferroptosis and macrophage polarization
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40609203
Ulcerative colitis (UC) is a relapsing inflammatory bowel disease with limited effective treatment options. Ferroptosis, characterized by lipid peroxidation-induced cellular death, is involved in UC pathogenesis. Propionic acid, a short-chain fatty acid, has demonstrated therapeutic potential in alleviating numerous conditions; however, its role and underlying mechanisms in UC remain unclear. …
Enzyme activated fluorescent probe for Vanin-1 multi-dimensional Imaging: Advanced insights for diagnosis and treatment of inflammatory bowel disease
Publication Year: 2025 Source: Free Radic Biol Med PMID: 40609803
Vanin-1, a GPI-anchored pantetheinase, has been implicated in various physiological and pathological processes and is a drug target for inflammatory bowel disease (IBD). We developed PHPO, a novel, specific and sensitive fluorogenic biosensor for Vanin-1 and validated its selectivity in VNN1(-/-) mice. Using PHPO, we imaged the endogenous distribution of …
Pickering emulsion gels stabilized by sardine protein/konjac glucomannan complexes delivering astaxanthin for alleviating inflammatory bowel disease
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40609948
Astaxanthin (AXT) alleviates inflammatory bowel disease (IBD) by reducing inflammation, blocking NF-kappaB pathway, and modulating gut microbiota. However, the poor solubility and low bioavailability of AXT limit its applications in food. In this study, sardine protein (SDP)/konjac glucomannan (KGM)-stabilized Pickering emulsion gels (SKEGs) were developed for AXT delivery for IBD …
Reverse polarity in pseudopyloric metaplasia in Crohn's disease
Publication Year: 2025 Source: J Clin Pathol PMID: 40610197
No Abstract
Patient knowledge and acceptance of the upcoming automatic substitution of biological medicines in community pharmacies: survey of Finnish patients with inflammatory bowel disease and psoriasis
Publication Year: 2025 Source: BMC Health Serv Res PMID: 40611165
BACKGROUND: Automatic substitution of biological medicines in community pharmacies is among the policy measures to contain increasing pharmaceutical costs, with gradual implementation starting in Finland in 2024. It is important to study patient knowledge of biological medicines, biosimilars, and substitution, as they have an impact on the success of automatic …
Pitfalls in the diagnosis of apparent homozygous mutations: two cases of IL10RA deficiency inflammatory bowel disease and a literature review
Publication Year: 2025 Source: Orphanet J Rare Dis PMID: 40611267
BACKGROUND: In East Asia, IL10RA is the predominant pathogenic gene in patients with very early-onset inflammatory bowel disease (VEO-IBD), frequently characterised by refractory diarrhoea and severe perianal disease, resulting in elevated death rates. IL10RA-deficient IBD, an autosomal recessive genetic disorder, has been documented to be inherited through the conventional compound …
Identification of key genes as diagnostic biomarkers for IBD using bioinformatics and machine learning
Publication Year: 2025 Source: J Transl Med PMID: 40611294
BACKGROUND: The pathogenesis of inflammatory bowel disease (IBD) involves complex molecular mechanisms, and achieving clinical remission remains challenging. This study aims to identify IBD-potential biomarkers, analyze their correlation with immune cell infiltration, and identify genes that have a causal relationship with IBD. METHODS: RNA-seq datasets for IBD were retrieved from …
Luohuazizhu Granules Alleviate Symptoms of Ulcerative Colitis via Changes in Bile Acid Metabolism and Gut Microbiota
Publication Year: 2025 Source: Comb Chem High Throughput Screen PMID: 40611408
INTRODUCTION: Luohuazizhu granules (LHZZG) are made of Callicarpa nudiflora Hook. (CN), which is used to treat ulcerative colitis (UC). The anti-inflammatory effects of CN on UC have been previously reported. However, the biological effects of LHZZG on bile acids (BAs) in UC and the underlying mechanisms remain unexplored. METHODS: Integrated …
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