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Medicinal Plant-Derived Carbon Dots Nanozymes Ameliorate Ulcerative Colitis via Anti-inflammatory, Antioxidant, and Gut Barrier-Protective Effects
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 40611517
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by oxidative stress, immune dysregulation, and compromised intestinal barrier integrity. Current therapeutic agents are frequently limited by safety concerns. To address this clinical challenge, we pioneered the development of an innovative nanotherapeutic system derived from the medicinal plant Atractylodes macrocephala …
Molecular Docking, Dynamics, and Preclinical Studies Reveal Morin Hydrate as a Potent PPARγ and Nrf2 Agonist That Mitigates Colon Inflammation
Publication Year: 2025 Source: Pharmacol Res Perspect PMID: 40611672
Peroxisome proliferator-activated receptors (PPARs), functioning as nuclear receptors, regulate the expression of genes associated with inflammation, lipid metabolism, and glucose metabolism. The primary isotypes of PPARs are PPARalpha, PPARbeta, and PPARgamma. PPARgamma is mostly expressed in adipose tissue and the colon. The activation of PPARgamma modulates signaling pathways associated with …
The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs
Publication Year: 2025 Source: bioRxiv PMID: 40611896
The Spatial Atlas of Human Anatomy (SAHA) represents the first multimodal, subcellular-resolution reference of healthy adult human tissues across multiple organ systems. Integrating spatial transcriptomics, proteomics, and histological features across over 15 million cells from more than 100 donors, SAHA maps conserved and organ-specific cellular niches in gastrointestinal and immune …
Warren Alpert Medical School of Brown University Annual Research Forum: Resident Project Winners
Publication Year: 2025 Source: J Brown Hosp Med PMID: 40612093
Resident project winners at the Warren Alpert Medical School of Brown University annual research forum.
Solitary Inflammatory Cap Polyp, An Unusual Cause of Rectal Bleeding in a Pediatric Patient: A Case Report
Publication Year: 2025 Source: Sage Open Pediatr PMID: 40612205
Solitary inflammatory cap polyp (ICP) is a rare rectal condition characterized by distinctive polypoid lesions with a "cap-like" appearance. It primarily occurs without underlying inflammatory bowel disease, making diagnosis and treatment challenging. We report the case of a 6-year-old female presenting with rectal bleeding and abdominal pain. Her medical history …
Exploring diet-microbiota interactions and therapeutic nutrition management in inflammatory bowel disease
Publication Year: 2025 Source: Biophys Rep PMID: 40612235
Intestinal bowel disease (IBD) is a chronic, early-onset, recurrent gastrointestinal immune-related disease that has become globalized. Although the combination of genetic, environmental, and immunological factors leads to intestinal inflammation and barrier damage, the etiology of IBD is not clearly defined. In recent years, diet-microbiota interactions have been widely studied for …
Comparison Between Adalimumab and Infliximab in Perianal Crohn's Disease: A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: Gastro Hep Adv PMID: 40612626
BACKGROUND AND AIMS: Anti-tumor necrosis factor therapy has been a mainstay of medical management of perianal Crohn's disease (CD). This systematic review and meta-analysis aimed to compare the efficacy of adalimumab (ADA) and infliximab (IFX) for the treatment of perianal fistulizing CD. METHODS: We searched PubMed, Embase, and Web of …
What is the impact on recruitment of a shortened compared with a standard-length participant information leaflet? PROMETHEUS in IBD-BOOST: study within a trial, a decentralised UK randomised controlled trial
Publication Year: 2025 Source: Trials PMID: 40528252 DOI: 10.1186/s13063-025-08931-6
BACKGROUND: Participant Information Leaflets (PILs) are lengthy and increasingly complex, and could deter research participation. A shortened PIL may be more appealing as it is likely to provide a more a manageable volume of information. Previous research has found that shortened PILs are no less effective for recruitment outcomes, and …
Management of paediatric ulcerative colitis, part 2: Acute severe colitis-An updated evidence-based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organization
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40528309
Acute severe colitis (ASC) is a relatively frequent manifestation in children with ulcerative colitis and one of the few emergencies in paediatric gastroenterology. A standardized proactive approach based on tight monitoring and timely medical and surgical interventions may improve patients' outcomes. We aimed to update the previous ASC guidelines using …
D-Tagatose attenuates DSS-induced ulcerative colitis by inhibiting inflammation, reducing intestinal barrier damage and modulating the intestinal flora composition
Publication Year: 2025 Source: Food Funct PMID: 40528436 DOI: 10.1039/d4fo06475e
Ulcerative colitis (UC) is a prevalent inflammatory bowel disease (IBD) posing a significant health threat. This study explored the protective effects of D-tagatose against DSS-induced colitis in mice and its underlying mechanisms using H&E staining, AB-PAS staining, immunofluorescence, immunohistochemistry, ELISA, qPCR, western blotting, and other assays. D-Tagatose improved colitis by …
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