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A probiotic multi-strain mixture combined with hydroxyectoine improves intestinal barrier function by alleviating inflammation in lipopolysaccharide stimulated differentiated Caco-2 cells
Publication Year: 2024 Source: Food Funct PMID: 39508078 DOI: 10.1039/d4fo03130j
Many studies have highlighted the role of probiotics in re-establishing the gut microbiota balance and preventing intestinal barrier dysfunction. In fact, they can also contribute to the upregulation of anti-inflammatory genes and the downregulation of pro-inflammatory genes, which are known to contribute to the development of the inflammatory bowel disease …
South African Rheumatism and Arthritis Association 2024 guidelines for the management of peripheral spondyloarthritis
Publication Year: 2024 Source: S Afr Med J PMID: 39508216 DOI: 10.7196/SAMJ.2024.v114i10.2669
Peripheral spondyloarthritis (SpA) includes psoriatic arthritis (PsA), inflammatory bowel disease (IBD)-associated arthritis, reactive arthritis and undifferentiated peripheral SpA. These South African guidelines offer information on diagnosis, assessment and therapy of peripheral SpA. Emphasis is placed on a multidisciplinary team, and a treat-to-target strategy with escalation of therapy if the target …
Multi-OMICs orchestration enabled by artificial intelligence in inflammatory bowel disease: An exciting future
Publication Year: 2024 Source: United European Gastroenterol J PMID: 39508313
No Abstract
DNA Nanopatch-Specific Modification of Probiotics for Ultrasound-Triggered Inflammatory Bowel Disease Therapy
Publication Year: 2024 Source: J Am Chem Soc PMID: 39508560
No Abstract
Fertility after pouch surgery in women with ulcerative colitis: Is robotic surgery the key to better outcomes?
Publication Year: 2024 Source: Womens Health (Lond) PMID: 39508620
No Abstract
A Novel Synbiotic Protects Against DSS-Induced Colitis in Mice via Anti-inflammatory and Microbiota-Balancing Properties
Publication Year: 2024 Source: Probiotics Antimicrob Proteins PMID: 39508961 DOI: 10.1007/s12602-024-10393-2
Inflammatory bowel disease (IBD) is a chronic immune-inflammatory disease. Gut microbes, intestinal immunity, and gut barrier function play a critical role in IBD. Growing evidence suggests that synbiotic may offer therapeutic benefits for individuals with colitis, suggesting an alternative therapy against colitis. With this in mind, we creatively prepared a …
A bidirectional Mendelian randomization analysis of the causal relationship between inflammatory bowel disease and breast cancer based on estrogen receptor status
Publication Year: 2024 Source: Discov Oncol PMID: 39508980 DOI: 10.1007/s12672-024-01514-y
The incidence of patients diagnosed with either breast cancer (BC) or inflammatory bowel disease (IBD) is increasing each year. IBD has been shown to be strongly associated with the development of a variety of solid tumors, but the relationship with breast cancer is not yet definitive. We explored the causative …
Efficacy and safety of Advanced Combination Treatment in immune-mediated inflammatory disease: A systematic review and meta-analysis of randomized controlled trials
Publication Year: 2024 Source: J Autoimmun PMID: 39509741 DOI: 10.1016/j.jaut.2024.103331
OBJECTIVES: Advanced combination treatment (ACT), defined as a combination of at least 2 biologic agents, a biologic agent and an oral small molecule, 2 oral small molecules drug with different mechanisms of action is a proposed strategy to improve outcomes in patients with immune-mediated inflammatory disease (IMID). We conducted a …
PHLDA1 protects intestinal barrier function via restricting intestinal epithelial cells apoptosis in inflammatory bowel disease
Publication Year: 2024 Source: Exp Cell Res PMID: 39510153 DOI: 10.1016/j.yexcr.2024.114322
The current approach to treating inflammatory bowel disease (IBD) primarily focuses on managing inflammation rather than maintaining the integrity of the intestinal barrier. In our study, we sought to investigate the potential role of PHLDA1 in preserving intestinal barrier function as a promising strategy for treating IBD. We observed a …
Dietary Antioxidant Capacity, Genetic Susceptibility and Polymorphism, and Inflammatory Bowel Disease Risk in a Prospective Cohort
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 39510220 DOI: 10.1016/j.cgh.2024.09.033
BACKGROUND & AIMS: Oxidative stress is an essential factor in the pathogenesis of inflammatory bowel disease (IBD). A previous study found protective potential of some antioxidative nutrients against IBD. However, the association between total antioxidant capacity (TAC) of the diet and incident IBD is unclear. METHODS: We conducted a prospective …
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