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Astragaloside IV: A Promising Drug to Prevent the Transition from Colitis to Colorectal Cancer
Publication Year: 2025 Source: Am J Chin Med PMID: 40530759 DOI: 10.1142/S0192415X25500405
Colorectal cancer (CRC) remains a major threat to health worldwide, partly due to the lack of effective treatments targeting the transition from inflammatory bowel disease (IBD) to malignancy. Astragaloside IV (AS-IV) is a major bioactive component from the traditional herb Astragalus membranaceus, and it has strong immunomodulatory and gastrointestinal protective …
Perianal Crohn's Disease Successfully Treated With Topical Ruxolitinib
Publication Year: 2025 Source: J Dermatol PMID: 40530803
No Abstract
Improving the patient care pathway and multidisciplinary management are major challenges in Hidradenitis suppurativa treatment
Publication Year: 2025 Source: Eur J Dermatol PMID: 40530932
Hidradenitis suppurativa (HS) is a chronic inflammatory disease resulting from the close interplay between genetic predisposition, dysregulation of the mechanisms involved in autoinflammatory pathways, dysfunctional response to bacterial biofilm changes, and environmental factors that potentially exacerbate the disease. Its cutaneous manifestations may represent just the tip of the iceberg, as …
Influence of Pharmacokinetic-Pharmacodynamic Failure Mechanisms on Outcomes in Biologic Therapy Sequencing in Inflammatory Bowel Disease: A Retrospective Cohort Study
Publication Year: 2025 Source: BioDrugs PMID: 40531271
BACKGROUND: Increasing therapeutic options for inflammatory bowel disease calls for tools to aid choice of sequencing. We investigated if pharmacokinetic (PK) and pharmacodynamic (PD) failure mechanisms prompting therapy change influenced subsequent outcomes when switching to a different biologic drug class. METHODS: Retrospective single-center cohort study including patients treated first with …
Inflammation-related polymorphisms IFNG-AS1 rs1558744 and CCAT2 rs6983267: Potential risk factors for ulcerative colitis
Publication Year: 2025 Source: Indian J Gastroenterol PMID: 40531297
BACKGROUND: Recent research indicates that long non-coding RNAs (lncRNAs) may have a regulatory role in inflammatory processes, potentially influencing the development of inflammatory bowel diseases such as ulcerative colitis (UC). However, the relationship between UC and lncRNAs remains unclear, highlighting the need for further research in this area. AIM: This …
Sexuality and health quality in patients with inflammatory bowel disease
Publication Year: 2025 Source: Pol Arch Intern Med PMID: 40531564
No Abstract
CALCULATION OF TOTAL ENERGY EXPENDITURE IN ADULTS WITH CROHN'S DISEASE BY INDIRECT CALORIMETRY AND SIMPLE WEIGHT-BASED EQUATIONS: A COMPARATIVE STUDY
Publication Year: 2025 Source: Arq Gastroenterol PMID: 40531684
BACKGROUND: Patients diagnosed with Crohn's disease (CD) are at high risk of nutritional impairment due to the symptoms and the intense inflammatory response of the disease. The use of indirect calorimetry (IC) to assess resting energy expenditure (REE) proves to be a valuable alternative for more accurately determining the energy …
Dietary Sugar and Sweetened Beverage Intake Increases Inflammatory Bowel Disease Risk: A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40532067 DOI: 10.1002/ueg2.70047
BACKGROUND AND AIMS: The impact of dietary sugar intake on the risk of developing inflammatory bowel disease is unclear, with inconsistent findings across studies. The aim of this systematic review and meta-analysis was to clarify how sugar consumption contributes to the risk of developing inflammatory bowel disease (IBD) using the …
Interaction Between Group 3 Innate Lymphoid Cells, Microbiota, and Intestinal Diseases: Mechanisms and Therapeutic Potential
Publication Year: 2025 Source: J Innate Immun PMID: 40532676 DOI: 10.1159/000546972
No Abstract
Fabrication and in vivo characterization of FRESH-based 3D printed chitosan construct for small intestine regeneration
Publication Year: 2025 Source: Biomed Mater PMID: 40532727 DOI: 10.1088/1748-605X/ade5e1
This study demonstrates the implantation of a 3D-printed small intestine construct using chitosan bioink and freeform reversible embedding of suspended hydrogels (FRESH) bioprinting technology. The research addresses the significant clinical challenges posed by inflammatory bowel disease (IBD) and short bowel syndrome (SBS), which often require surgical interventions leading to substantial …
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