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Senescence, Aging and Disease Throughout the Gastrointestinal System

Publication Year: 2025 Source: Gastroenterology PMID: 40532827

Senescence is an irreversible cell cycle arrest-characterized by morphologic alterations, genomic instability, and secretome changes-that profoundly affects the tissue structure and function. Accumulating evidence indicates that senescence plays a relevant role in gastrointestinal pathologies: senescence contributes to salivary gland hypofunction, is instrumental in the development of oral submucous fibrosis, drives …

Novel combination closure of an artificial ulcer after gastric endoscopic submucosal dissection using a double-arm-bar suturing system and an anchor prong clip

Publication Year: 2025 Source: Endoscopy PMID: 40532904

No Abstract

Diagnostic dilemmas: using the multidisciplinary expertise

Publication Year: 2025 Source: BMJ Case Rep PMID: 40533108

No Abstract

Clinical profile of patients with comorbid IBD and MS, and associated service impact in England's secondary care setting: a retrospective cohort study

Publication Year: 2025 Source: BMJ Open PMID: 40533207 DOI: 10.1136/bmjopen-2024-088808

OBJECTIVES: Inflammatory bowel diseases (IBDs) and multiple sclerosis (MS) are inflammatory diseases resulting from an interplay of genetic and environmental factors. This study aims to describe the prevalence of patients diagnosed with both conditions among those receiving hospital care in England, as well as the characteristics and healthcare resource use …

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation

Publication Year: 2025 Source: Nature PMID: 40533562

The microbiota has been recognized as a critical contributor to various diseases(1), with multiple reports of changes in the composition of the gut microbiome in contexts such as inflammatory bowel disease(2,3) and neurodegenerative diseases(4). These microbial shifts can exert systemic effects by altering the release of specific metabolites into the …

Impact of Social Isolation on Inflammatory Bowel Disease Risk and the Mitigating Effect of a Healthy Lifestyle

Publication Year: 2025 Source: Int J Behav Med PMID: 40533707 DOI: 10.1007/s12529-025-10373-y

BACKGROUND: We aimed to evaluate the association of social isolation with incident inflammatory bowel disease (IBD) risk, as well as to investigate whether and to what degree a healthy lifestyle attenuates IBD risk linked to social isolation. METHODS: This UK Biobank cohort study included 429,843 participants without a prior diagnosis …

Pediatric inflammatory bowel disease in patients of Middle Eastern descent seen at a large urban children's hospital

Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40534116 DOI: 10.1002/jpn3.70127

No Abstract

Oral Microbiota Dysbiosis Initiated by Chronic Colitis and the Possible Role in Oral Mucosa Changes

Publication Year: 2025 Source: Oral Dis PMID: 40534416 DOI: 10.1111/odi.15344

OBJECTIVE: To investigate oral microbiota dysbiosis and cytopathological changes in oral mucosa of murine chronic colitis model and the correlation between them. METHODS: Dextran sodium sulfate (DSS) induced chronic colitis was established in SPF C57BL/6 male mice, oral microbiome characterization was performed using 16S rRNA gene sequencing, and cytopathological and …

Evolution of practice of robotic ileoanal pouches: a single-center case series in East London

Publication Year: 2025 Source: J Minim Invasive Surg PMID: 40534522

Robotic ileal pouch-anal anastomosis offers improved ergonomics and dexterity, leading to increased use. This study presents our initial series, describing technique and outcomes from a nationally accredited district general hospital. Data of consecutive patients who underwent robotic restorative proctocolectomy, between January 2021 and August 2024 was presented. Da Vinci Xi …

Evaluating the predictive effect of vitamin D on clinical outcomes of infliximab-treated Crohn's disease patients

Publication Year: 2025 Source: Front Immunol PMID: 40534845

BACKGROUNDS: The aim of this study was to examine the clinical predictors of Infliximab (IFX) in Crohn's disease (CD) patients in eastern China and to support further research on the vitamin D remission rate compared to CD patients. METHODS: Patients with CD who were hospitalized at Xuzhou First People's Hospital …

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