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Risk of new-onset inflammatory bowel disease in psoriasis patients treated with five different interleukin inhibitors: a systematic review and meta-analysis
Publication Year: 2025 Source: Front Immunol PMID: 40534876 DOI: 10.3389/fimmu.2025.1594998
BACKGROUND: Interleukin inhibitors represent a standard therapeutic approach for psoriasis. However, there is still debate about the risk of new-onset inflammatory bowel disease (IBD) in psoriasis patients following interleukin inhibitor treatment. This systematic review and meta-analysis aims to evaluate the risk of new-onset IBD in psoriasis patients treated with five …
Mechanism of cell death and its application in the repair of inflammatory bowel disease by mesenchymal stem cells
Publication Year: 2025 Source: Front Immunol PMID: 40534879 DOI: 10.3389/fimmu.2025.1597462
The onset and progression of inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, are influenced by the immune system, environmental factors, genetics, and intestinal flora. Cell death is a biological phenomenon that occurs in all living organisms; nevertheless, excessive cell death has been linked to IBD, including …
The Efficacy of Ayurvedic Herbs in the Prevention and Treatment of Inflammatory Bowel Disease: A Scoping Review
Publication Year: 2025 Source: Cureus PMID: 40535387 DOI: 10.7759/cureus.84410
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with no known cure in Western medicine. While steroids and other anti-inflammatory treatments help manage symptoms, Ayurvedic herbs and spices offer a holistic approach rooted in Ayurveda, an ancient Indian medical system that aims to balance life's …
Prospective observational study of tofacitinib in ulcerative colitis - analysis of clinical data, fatigue and health-related quality of life during the induction phase
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40535533
BACKGROUND: Tofacitinib is a Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Prospective real-world data are scarce. OBJECTIVES: To collect data on clinical outcomes, including health-related quality of life (HRQoL) and fatigue during treatment with tofacitinib. DESIGN: This is a prospective observational multicentre study in Sweden. In this …
The Role of Five-Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview
Publication Year: 2025 Source: ChemMedChem PMID: 40536013
Over the past decades, extensive scientific research in the fields of chemistry and pharmaceutical chemistry has led to the synthesis and study of numerous chemical compounds with diverse therapeutic applications. Many of these compounds feature heterocyclic aromatic structures, including four-, five-, and six-membered rings. Among them, five-membered heteroaromatic rings have …
Nonemergency colectomy for inflammatory bowel disease: the National Consultant Information Programme (NCIP) used to highlight colorectal surgery practice and outcomes in England 2018-2022
Publication Year: 2025 Source: Ann R Coll Surg Engl PMID: 40536417 DOI: 10.1308/rcsann.2025.0041
INTRODUCTION: The National Consultant Information Programme (NCIP) tool provides a platform for NHS consultants to benchmark their practice and for trusts to have a purview of the range, variation and outcomes of surgical procedures. Surgery remains an effective strategy for the treatment of inflammatory bowel disease (IBD) despite advances in …
Multi-Omics Analysis of Ileal Mucosa and Mesentery Before and After Ileocecal Resection in Crohn's Disease
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40536441 DOI: 10.1002/ueg2.70069
Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic disorder involving any part of the gastrointestinal tract. Ileocecal resection may serve as a more effective treatment option for early CD. However, the potential relationship and mechanisms between the ileocecum and remission induction of CD are still …
Clinical and Genetic Profile of 35 Patients with Glycogen Storage Disease Type 1b: A Comparative Analysis Before and During SGLT2 Inhibitor Therapy
Publication Year: 2025 Source: Mol Diagn Ther PMID: 40536628 DOI: 10.1007/s40291-025-00795-5
BACKGROUND: Glycogen storage disease type 1b (GSD 1b) is an ultra-rare disease worldwide, whereas in Serbia it has an unexpectedly high prevalence. GSD 1b is the result of variants in the SLC37A4 gene and reduced function of the enzyme glucose 6 phosphate translocase (G6PT). In addition to the classic symptoms …
Cold-blooded vertebrates evolved regulatory B cells to participate in inflammatory diseases
Publication Year: 2025 Source: Cell Commun Signal PMID: 40537793 DOI: 10.1186/s12964-025-02311-y
BACKGROUND: Regulatory B cell (Breg), known for its immunosuppressive properties through the provision of IL-10, plays a critical role in the control of inflammatory diseases. Although Breg has been discovered for over two decades in mammals, its existence in non-mammalian vertebrates remains unclear. Here, we aimed to explore the differentiation …
Nanoparticle-Driven Modulation of Mucosal Immunity and Interplay with the Microbiome
Publication Year: 2025 Source: J Microbiol Biotechnol PMID: 40537897
Mucosal surfaces are dynamic immunological interfaces that play a critical role in maintaining host defense and microbial homeostasis. Disruptions in the interaction between the mucosal immune system and its commensal microbiota have been associated with the onset of several diseases, including inflammatory bowel disease, asthma, and bacterial vaginosis. This review …
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