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Balinatunfib: A Clinical Oral Small Molecule TNFα Inhibitor
Publication Year: 2025 Source: ChemMedChem PMID: 40537931
Most diseases are accompanied by an inflammatory response, making effective pharmacological control highly desirable. Tumor necrosis factor alpha (TNFalpha) is a key cytokine driving inflammatory and autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel disease. Although biological TNFalpha inhibitors revolutionized treatment, they have drawbacks including lacking blood-brain barrier penetration, …
Overlapping inflammatory bowel and irritable bowel: Time to screen for parental catastrophizing
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40537962
No Abstract
Classification of pediatric video capsule endoscopy images for small bowel abnormalities using deep learning models
Publication Year: 2025 Source: World J Gastroenterol PMID: 40538507
BACKGROUND: Video capsule endoscopy (VCE) is a noninvasive technique used to examine small bowel abnormalities in both adults and children. However, manual review of VCE images is time-consuming and labor-intensive, making it crucial to develop deep learning methods to assist in image analysis. AIM: To employ deep learning models for …
Longitudinal computed tomography-based delta-radiomics of visceral adipose tissue predicts infliximab secondary loss of response in Crohn's disease patients
Publication Year: 2025 Source: World J Gastroenterol PMID: 40538512
BACKGROUND: Visceral adipose tissue (VAT) plays a role in the pathogenesis of Crohn's disease (CD) and is associated with treatment outcomes following infliximab (IFX) therapy. We developed and validated the first delta-radiomics model to quantify VAT heterogeneity as a predictive biomarker for IFX response in patients with CD. AIM: To …
The Correlation between Hidradenitis Suppurativa and Irritable Bowel Diseases: A Systematic Review
Publication Year: 2025 Source: J Clin Aesthet Dermatol PMID: 40538531
BACKGROUND: Hidradenitis suppurativa (HS) is an inflammatory skin condition that presents with nodules or abscesses associated with sinus tracts. Inflammatory bowel diseases (IBD) are inflammatory gastrointestinal (GI) conditions presenting with irregular bowel movements. Although HS and IBDs may have similarities in their clinical presentation and pathophysiology, they can differ in …
Microalgal-enhanced cerium oxide nanotherapeutics for alleviating inflammatory bowel disease via scavenging reactive oxygen species and modulating gut microbiota in colitis
Publication Year: 2025 Source: Mater Today Bio PMID: 40538752 DOI: 10.1016/j.mtbio.2025.101945
Inflammatory bowel disease (IBD) poses significant therapeutic challenges due to its complex pathophysiology, which involves oxidative stress and dysbiosis of the intestinal microbiota. Antioxidant nanozymes offer promising intervention options because of their potent reactive oxygen species (ROS)-scavenging abilities; however, their instability and leakage in the upper gastrointestinal tract remain major …
Pyoderma gangrenosum, peripheral ulcerative keratitis, and oral ulcers in a patient with inflammatory bowel disease
Publication Year: 2025 Source: JAAD Case Rep PMID: 40538783
No Abstract
Immune dysregulation in ulcerative colitis: pathogenic mechanisms and therapeutic strategies of traditional Chinese medicine
Publication Year: 2025 Source: Front Cell Dev Biol PMID: 40538978 DOI: 10.3389/fcell.2025.1610435
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized primarily by immune dysregulation. Its pathogenesis involves multiple factors, including dysregulation of T-cell subsets, hypersecretion of pro-inflammatory cytokines, imbalance in the gut microbiota, and disruption of the intestinal barrier. Among T-cell subsets, abnormal activation of Th1 and Th17 cells, …
Exploring the gut-exercise link: A systematic review of gastrointestinal disorders in physical activity
Publication Year: 2025 Source: World J Gastroenterol PMID: 40539198
BACKGROUND: The relationship between exercise and gastrointestinal (GI) health is complex and bidirectional. While moderate exercise generally promotes gut health by enhancing motility, reducing inflammation, and supporting microbial balance, intense or prolonged physical activity may exacerbate GI symptoms, particularly in individuals with pre-existing digestive disorders. A deeper understanding of this …
Reevaluating therapeutic strategies in Crohn's disease: Comparing Modulen and budesonide
Publication Year: 2025 Source: World J Gastroenterol PMID: 40539199
This article explores the significant implications of the study by Ovadia et al, which innovatively compares the efficacy of a nutritional intervention (Modulen) to conventional pharmaceutical therapy (budesonide) in promoting mucosal healing in Crohn's disease. Highlighting the paradox of a well-established yet underutilized nutritional approach, the findings suggest that Modulen …
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