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Protective effect of sucrose esters from cape gooseberry (Physalis peruviana L.) in TNBS-induced colitis
Publication Year: 2024 Source: PLoS One PMID: 38512973 DOI: 10.1371/journal.pone.0299687
Phytotherapy is an attractive strategy to treat inflammatory bowel disease (IBD) that could be especially useful in developing countries. We previously demonstrated the intestinal anti-inflammatory effect of the total ethereal extract from the Physalis peruviana (Cape gooseberry) calyces in TNBS-induced colitis. This work investigates the therapeutic potential of Peruviose A …
Patient Perspectives of Bowel Urgency and Bowel Urgency-Related Accidents in Ulcerative Colitis and Crohn's Disease
Publication Year: 2024 Source: Inflamm Bowel Dis PMID: 38513272
No Abstract
Opposing diet, microbiome, and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host
Publication Year: 2024 Source: Cell Host Microbe PMID: 38513656 DOI: 10.1016/j.chom.2024.03.001
Inflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with host genetics, diet and gut bacteria are thought to contribute prominently to IBDs, but mechanisms are still emerging. In mice lacking the IBD-associated cytokine, interleukin-10, we show that …
Biobank-scale inference of multi-individual identity by descent and gene conversion
Publication Year: 2024 Source: Am J Hum Genet PMID: 38513668 DOI: 10.1016/j.ajhg.2024.02.015
We present a method for efficiently identifying clusters of identical-by-descent haplotypes in biobank-scale sequence data. Our multi-individual approach enables much more computationally efficient inference of identity by descent (IBD) than approaches that infer pairwise IBD segments and provides locus-specific IBD clusters rather than IBD segments. Our method's computation time, memory …
What impact has the Centre of Research Excellence in Digestive Health made in the field of gastrointestinal health in Australia and internationally? Study protocol for impact evaluation using the FAIT framework
Publication Year: 2024 Source: BMJ Open PMID: 38514142
No Abstract
Dual RNA sequencing of Helicobacter pylori and host cell transcriptomes reveals ontologically distinct host-pathogen interaction
Publication Year: 2024 Source: mSystems PMID: 38514462
No Abstract
Role of pH-sensing receptors in colitis
Publication Year: 2024 Source: Pflugers Arch PMID: 38514581 DOI: 10.1007/s00424-024-02943-y
Low pH in the gut is associated with severe inflammation, fibrosis, and colorectal cancer (CRC) and is a hallmark of active inflammatory bowel disease (IBD). Subsequently, pH-sensing mechanisms are of interest for the understanding of IBD pathophysiology. Tissue hypoxia and acidosis-two contributing factors to disease pathophysiology-are linked to IBD, and …
DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis tissue biopsies
Publication Year: 2024 Source: Sci Rep PMID: 38514698 DOI: 10.1038/s41598-024-57440-0
DNA methylation has been implied to play a role in the immune dysfunction associated with inflammatory bowel disease (IBD) and the disease development of ulcerative colitis (UC). Changes of the DNA methylation and correlated gene expression in patient samples with inactive UC might reveal possible regulatory features important for further …
A rare colonoscopic finding in a renal transplant recipient
Publication Year: 2024 Source: Clin Endosc PMID: 38514986
No Abstract
Immunotherapy of gastric cancer: Present status and future perspectives
Publication Year: 2024 Source: World J Gastroenterol PMID: 38516237
No Abstract
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