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The epithelium takes the stage in asthma and inflammatory bowel diseases
Publication Year: 2024 Source: Front Cell Dev Biol PMID: 38529406 DOI: 10.3389/fcell.2024.1258859
The epithelium is a dynamic barrier and the damage to this epithelial layer governs a variety of complex mechanisms involving not only epithelial cells but all resident tissue constituents, including immune and stroma cells. Traditionally, diseases characterized by a damaged epithelium have been considered "immunological diseases," and research efforts aimed …
Adolescent and caregiver perceptions of addressing mental health in inflammatory bowel disease
Publication Year: 2024 Source: J Child Health Care PMID: 38530035 DOI: 10.1177/13674935241241350
Adolescents with inflammatory bowel disease (IBD) are at an increased risk of anxiety and depression compared to peers, but availability of mental health services in IBD clinics does not meet patients' needs, and use of primary care services for mental health screening and care is low. This study provides qualitative …
Rapid Onset of Intestinal Lymphoma in Crohn Disease
Publication Year: 2024 Source: Radiology PMID: 38530169
No Abstract
Effect of Tofacitinib on One-Year Colectomy Risk in Anti-TNF Refractory Ulcerative Colitis: A Prospective Multicenter Italian Study
Publication Year: 2024 Source: Dig Dis Sci PMID: 38530500
No Abstract
Geraniin Alleviates Inflammation in Caco-2 Cells and Dextran Sulfate Sodium-Induced Colitis Mice by Targeting IL-1β
Publication Year: 2024 Source: J Agric Food Chem PMID: 38530797 DOI: 10.1021/acs.jafc.3c09396
IL-1beta is an important cytokine implicated in the progression of inflammatory bowel disease (IBD) and intestinal barrier dysfunction. The polyphenolic compound, geraniin, possesses bioactive properties, such as antitumor, antioxidant, anti-inflammatory, antihypertensive, and antiviral activities; however, its IL-1beta-targeted anticolitis activity remains unclear. Here, we evaluated the inhibitory effect of geraniin in …
Simultaneous Presentation of Takayasu Arteritis and Crohn's Disease in a Middle-Aged Patient: Are they two sides of the same coin?
Publication Year: 2024 Source: BMJ Case Rep PMID: 38531553
No Abstract
Precise infliximab exposure and pharmacodynamic control to achieve deep remission in paediatric Crohn's disease (REMODEL-CD): study protocol for a multicentre, open-label, pragmatic clinical trial in the USA
Publication Year: 2024 Source: BMJ Open PMID: 38531570
No Abstract
Guselkumab provides durable improvement across psoriatic arthritis disease domains: post hoc analysis of a phase 3, randomised, double-blind, placebo-controlled study
Publication Year: 2024 Source: RMD Open PMID: 38531621 DOI: 10.1136/rmdopen-2023-003977
OBJECTIVE: Evaluate long-term guselkumab effectiveness across Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)-recognised domains/related conditions of psoriatic arthritis (PsA). METHODS: Post hoc analyses used data from DISCOVER-2 (NCT03158285) biologic/Janus-kinase inhibitor-naive participants with active PsA (>/=5 swollen/>/=5 tender joints, C-reactive protein >/=0.6 mg/dL), randomised (1:1:1) to guselkumab …
In-hospital outcomes and trends of patients with autoimmune diseases undergoing percutaneous coronary intervention: A nationwide analysis
Publication Year: 2024 Source: Cardiovasc Revasc Med PMID: 38531708 DOI: 10.1016/j.carrev.2024.02.020
BACKGROUND: The risk of coronary artery disease is exaggerated in patients with autoimmune diseases (AID). A higher risk of complications has been reported during and after percutaneous coronary intervention (PCI) in these patients. We aimed to analyze the in-hospital outcomes and trends of patients with AID, including rheumatoid arthritis (RA), …
Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice
Publication Year: 2024 Source: Nat Commun PMID: 38531874 DOI: 10.1038/s41467-024-46983-5
Host molecular responses to fecal microbiota transplantation (FMT) in ulcerative colitis are not well understood. Here, we profile the human colonic mucosal transcriptome prior to and following FMT or placebo to identify molecules regulated during disease remission. FMT alters the transcriptome above the effect of placebo (n = 75 vs …
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