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Shared decision-making improves adherence to mesalamine in ulcerative colitis: A prospective, multicenter, non-interventional cohort study in Germany
Publication Year: 2025 Source: World J Gastroenterol PMID: 40539204
BACKGROUND: Mesalamine is the recommended first-line treatment for inducing and maintaining remission in mild-to-moderate ulcerative colitis (UC). However, adherence in real-world settings is frequently suboptimal. Encouraging collaborative patient-provider relationships may foster better adherence and patient outcomes. AIM: To quantify the association between patient participation in treatment decision-making and adherence to …
Phenolic Ethanolic Extracts of Specialty Sorghum Ameliorate Intestinal Colitis and Inflammation Induced by Dextran Sulfate Sodium in Mice
Publication Year: 2025 Source: Biofactors PMID: 40539417
Recently, sorghum [Sorghum bicolor (L.) Moench] has been given great attention as an excellent source of polyphenols that exhibit protective effects against multiple chronic disease models. Ulcerative colitis (UC) is strongly linked to the incidence of colon cancer and other intestinal chronic diseases. This study aimed to determine the ability …
Multiomics Analysis of Bacteroides cellulosilyticus Anticolitis via Gut Microbiota Metabolite-Mediated PI3K-Akt Signaling Pathway
Publication Year: 2025 Source: J Agric Food Chem PMID: 40539526
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation and dysbiosis of the gut microbiota. Bacteroides cellulosilyticus (B. cellulosilyticus) is a multifunctional carbohydrate-degrading bacterium that may serve as a probiotic to enhance gut health by regulating gut microbiota. However, its specific role and mechanisms in UC …
Identification of overlapping genetic loci between inflammatory bowel disease and major depressive disorder
Publication Year: 2025 Source: Eur Arch Psychiatry Clin Neurosci PMID: 40539999
No Abstract
Applying Biomarkers in Treat-to-target Approach for IBD
Publication Year: 2025 Source: Curr Gastroenterol Rep PMID: 40540152 DOI: 10.1007/s11894-025-00991-7
PURPOSE OF REVIEW: The treatment of inflammatory bowel disease (IBD) has evolved significantly over time based on "treat-to-target", an approach which uses sequential objective makers to monitor response to therapy with the ultimate goal of achieving endoscopic healing. Biomarkers, including C-reactive protein and fecal calprotectin, are an important noninvasive intermediate …
The Causal Association between Total Bilirubin, Direct Bilirubin, and Ulcerative Colitis: A Two-Sample Mendelian Randomization Study
Publication Year: 2025 Source: Cell Biochem Biophys PMID: 40540201
Bilirubin, a product of heme metabolism, has been linked to various inflammatory conditions. Ulcerative colitis, a chronic inflammatory bowel disease, and the causal relationship between bilirubin and ulcerative colitis remains unclear. This study investigates whether bilirubin levels have a causal effect on the risk of ulcerative colitis using a Mendelian …
Camellia oleifera oil: unveiling health benefits and exploring novel applications
Publication Year: 2025 Source: Crit Rev Food Sci Nutr PMID: 40540300
Camellia oleifera (C. oleifera) oil, commonly referred to as "Oriental olive oil," is renowned for its bioactive composition and associated health benefits. This review highlights its key constituents-unsaturated fatty acids, polyphenols, phytosterols, squalene, and vitamin E-and their therapeutic effects. Research indicates that it aids in the management of cardiovascular diseases …
Incidence and relative risk of colorectal cancer in autoimmune diseases: a global pooled-analysis with more than 91 million participants
Publication Year: 2025 Source: Int J Surg PMID: 40540456
BACKGROUND: Dysregulation of immune system could be a vital stimulant of colorectal cancer development. However, there was lacking of a comprehensive and rigorously conducted meta-analysis on association between autoimmune diseases and risk of colorectal cancer. METHODS: Literature retrieval was performed based on PubMed, Web of Science, and Embase from inception …
Uncovering common disease mechanisms and critical biomarkers in Crohn's disease with concurrent psoriasis and exploring potential therapeutic agents
Publication Year: 2025 Source: PLoS One PMID: 40540498
INTRODUCTION: Research findings show a substantial correlation between Crohn's disease and psoriasis. However, the exact cause or pathogenesis of the concurrent manifestations of these two conditions in the same individuals remains uncertain. This research aimed to scrutinize the important molecules and mechanisms responsible for the concomitance of Crohn's disease and …
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity
Publication Year: 2025 Source: Sci Immunol PMID: 40540585 DOI: 10.1126/sciimmunol.adq8860
Pathogenic CD4 T cells drive autoimmunity in diseases such as multiple sclerosis (MS) and inflammatory bowel disease (IBD). Through a forward genetic screen, we identified chloride nucleotide-sensitive channel 1A (CLNS1A) as a key regulator of inflammation in the experimental autoimmune encephalomyelitis (EAE) model of MS. CLNS1A is expressed in several …
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