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Participation bias in the estimation of heritability and genetic correlation
Publication Year: 2025 Source: Proc Natl Acad Sci U S A PMID: 40540605 DOI: 10.1073/pnas.2425530122
It is increasingly recognized that participation bias can pose problems for genetic studies. Recently, to overcome the challenge that genetic information of nonparticipants is unavailable, it is shown that by comparing the IBD (identity by descent) shared and not-shared segments between participating relative pairs, one can estimate the genetic component …
Prevalence and management of gastrointestinal complications in Duchenne muscular dystrophy: A retrospective cohort study
Publication Year: 2025 Source: Brain Dev PMID: 40540814
BACKGROUND: Gastrointestinal complications in Duchenne muscular dystrophy (DMD) have been understudied, particularly in Asian populations. This study aimed to determine the frequency and clinical characteristics of gastrointestinal complications. METHODS: This single-center, retrospective study reviewed medical records of 459 Asian patients with genetically or biopsy-confirmed DMD, aged 1-48 years, from September …
Curing inflammatory bowel diseases: breaking the barriers of current therapies- emerging strategies for a definitive treatment
Publication Year: 2025 Source: Curr Opin Immunol PMID: 40540980 DOI: 10.1016/j.coi.2025.102593
Chronic intestinal inflammation in inflammatory bowel diseases (IBD) reflects the interplay of genetic predisposition, immune dysregulation, microbial imbalance, and epithelial barrier defects. Current therapies for IBD primarily focus on controlling inflammation necessitating lifelong treatment and face a 'therapeutic ceiling' due to primary and secondary loss of efficacy over time. Immune-mediated …
From parasite to partner: unravelling the multifaceted role of Blastocystis in human health and disease
Publication Year: 2025 Source: Lancet Microbe PMID: 40541220
Blastocystis, a common protist in the human gut microbiota, has been identified as a key modulator of gut health and disease progression. Research highlights the involvement of Blastocystis in inflammatory bowel disease, cognitive function, and metabolic health. Despite an increasing interest on this topic, the literature on Blastocystis remains fragmented …
Temporal trends in surgical treatment of inflammatory bowel disease following introduction of biological drugs in Norway and Sweden
Publication Year: 2025 Source: BMJ Open Gastroenterol PMID: 40541271 DOI: 10.1136/bmjgast-2025-001828
OBJECTIVE: The advent of biological drugs has revolutionised management of inflammatory bowel disease (IBD). However, the extent to which these novel pharmacological drugs have reduced the need for surgical treatment remains incompletely quantified.We aimed to investigate the risk of first, major surgery in IBD in a population-based, large epidemiological study. …
When inflammatory bowel disease meets pregnancy
Publication Year: 2025 Source: Eur J Intern Med PMID: 40541457 DOI: 10.1016/j.ejim.2025.06.014
Inflammatory bowel disease (IBD) is a group of chronic and relapsing inflammatory conditions that affect the gastrointestinal tract. Women of reproductive age comprise a significant proportion of patients with IBD. The management of IBD during pregnancy presents unique and complex challenges that have garnered increasing attention recently. Moreover, considerable attention …
Vitamin D status in Faroese adults and its association with inflammatory bowel diseases - a cross-sectional study from the FarGen 2 project
Publication Year: 2025 Source: Int J Circumpolar Health PMID: 40541564
Vitamin D is vital for physiological functions and is obtained primarily through sunlight and a few dietary sources. With limited sunlight exposure, the Faroe Islands face challenges in maintaining sufficient levels of vitamin D, while the Faroese population has documented the highest incidence and prevalence of inflammatory bowel disease worldwide. …
Barriers and Opportunities to Improve Shared Decision-Making for Patients with Ulcerative Colitis: A Qualitative Study
Publication Year: 2025 Source: J Gastrointest Surg PMID: 40541607 DOI: 10.1016/j.gassur.2025.102125
BACKGROUND: Surgical decision-making for Ulcerative Colitis (UC) is complex and often occurs under challenging clinical circumstances. While shared decision-making (SDM) can enhance patient-centered care, there is limited understanding of how patients experience this process, particularly across diverse populations. This study explores barriers and facilitators to SDM among patients who have …
IL-10 alleviates ulcerative colitis by regulating mitochondrial function through reducing ISG15 expression
Publication Year: 2025 Source: Cell Signal PMID: 40541818
BACKGROUND: Interleukin-10 (IL-10), an anti-inflammatory cytokine, has shown therapeutic effect on autoimmune diseases, yet its effects on UC remain unclear. This study aims to investigate whether the administration of IL-10 can suppress disease flares in ulcerative colitis (UC). METHODS: A UC model was established in mice using dextran sulfate sodium …
CCL20 expression is elevated in inflammatory bowel disease and attenuated by vitamin D metabolites
Publication Year: 2025 Source: Sci Rep PMID: 40542081
Intestinal epithelial overexpression of the Th17 cell chemoattractant CCL20 is implicated in inflammatory bowel disease and influenced by NOD2 mutations in Crohn's disease. Vitamin D metabolites have been shown to ameliorate inflammatory bowel disease. Considering NOD2 mutations in Crohn's disease, we investigated whether Vitamin D deficiency (serum 25-hydroxyvitamin D concentration …
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