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Management of Hidradenitis Suppurativa in Special Populations: A Narrative Review
Publication Year: 2025 Source: Dermatol Ther (Heidelb) PMID: 40542230 DOI: 10.1007/s13555-025-01457-4
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that can be treated with a variety of medical and surgical therapies. However, these therapies carry inherent risks that might be heightened in medically complex patients. This narrative review examines literature for the nuances of standard HS management in immunosuppressed individuals, …
Current status of fertility rates and modes of delivery after restorative proctocolectomy with ileal pouch-anal anastomosis
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 40542270
PURPOSE: After restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA), fertility rates decline, and cesarean section (CS) has been the preferred mode of delivery. We aimed to assess the current trends and outcomes of pregnancy and delivery in patients who underwent RPC with IPAA. METHODS: This retrospective cohort study included …
Excretory/secretory products from Hymenolepis nana adult worms alleviate ulcerative colitis in mice via tuft/IL-13 signaling pathway
Publication Year: 2025 Source: Parasit Vectors PMID: 40542404
BACKGROUND: Hymenolepis nana (H. nana) is a zoonotic parasitic worm that parasitizes the small intestines of humans and rodents. Ulcerative colitis (UC) is a chronic and recurrent inflammatory bowel disease. Current symptom-based clinical treatments do not alter the natural course of UC, and mucosal healing has become a primary therapeutic …
5'-tiRNA-Lys maintains intestinal epithelial homeostasis by EWSR1-dependent suppression of miR-125a and autophagy activation
Publication Year: 2025 Source: Acta Biochim Biophys Sin (Shanghai) PMID: 40542577 DOI: 10.3724/abbs.2025074
The intestinal epithelium relies on autophagy to maintain barrier integrity and homeostasis, and dysregulation of this process has been implicated in inflammatory bowel disease (IBD). While tRNA-derived small RNAs (tsRNAs) are emerging as regulators of cellular stress responses, their roles in intestinal autophagy remain poorly understood. Here, we identify that …
Impact of Psychosocial Risk Factors on Acute Clinical Outcomes Following Colectomy: A National Perspective
Publication Year: 2025 Source: Am Surg PMID: 40542583
BackgroundA growing body of work has considered the significance of patients' psychosocial support and surrounding socioeconomic milieu on surgical outcomes. The presence of such psychosocial risk factors (PSRFs) may define both access to and engagement with care, particularly for access-sensitive conditions, such as colon resection. Yet, the impact of PSRF …
Chitosan nanoparticles of rutin mitigated histological changes induced in DNCB-induced colitis by enhanced modulation of inflammation and oxidative stress
Publication Year: 2025 Source: J Mol Histol PMID: 40542885 DOI: 10.1007/s10735-025-10491-7
Inflammatory bowel disease (IBD) is a chronic inflammatory illness of the colon involving increased production of reactive oxygen species (ROS) and involvement of inflammatory cytokinins. The present study aimed to alleviate colitis condition in rats by rutin-loaded chitosan nanoparticles for improving rutin's release profile, solubility, as well as targetability of …
Therapeutic potential of wavelength-dependent photobiomodulation on gut inflammation in an in vitro intestinal model
Publication Year: 2025 Source: J Photochem Photobiol B PMID: 40543454
Recently, photobiomodulation (PBM) has emerged as a novel therapeutic approach for modulating the gut microbiome, offering potential for the regulation of intestinal inflammation. Although PBM has been primarily used for various clinical applications, recent studies suggest that its effects may extend to the regulation of microbial imbalances and chronic inflammation. …
Scavenger receptors: An auspicious therapeutic target for autoimmune diseases
Publication Year: 2025 Source: Clin Immunol PMID: 40543695 DOI: 10.1016/j.clim.2025.110546
Scavenger receptors (SRs) belong to a large receptor family expressed on immune and non- immune cells. Initially, SRs are regarded as removers able to recognize and clear modified lipoproteins; However, it is now realized that they are pattern recognition receptors (PRRs) that identify damage-associated molecular pattern (DAMP) and pathogen-associated molecular …
MicroRNAs as Key Modulators of Intestinal Barrier Function: Pattern Recognition Receptors, Epithelial Junctional Complexes, and Therapeutic Approaches
Publication Year: 2025 Source: Dig Dis Sci PMID: 40544176 DOI: 10.1007/s10620-025-09131-7
PURPOSE: This review aims to investigate the regulatory role of microRNAs (miRNAs) in intestinal barrier function, with a focus on their interaction with pattern recognition receptors (PRRs) such as Toll-like receptors (TLR2, TLR4, TLR5) and nucleotide-binding oligomerization domain (NOD) receptors. Additionally, the review explores how miRNAs influence epithelial junctional complexes-including …
Autoimmune Diseases and Pregnancy - Is There a Greater Risk of Giving Birth to a Sick Child?
Publication Year: 2025 Source: Arch Immunol Ther Exp (Warsz) PMID: 40544482 DOI: 10.2478/aite-2025-0017
This study aims to describe the impact of some of the most common autoimmune diseases, such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), myasthenia gravis (MG), chronic inflammatory bowel disease (IBD), type 1 diabetes (T1D), autoimmune thyroid disease, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis, vasculitis, …
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