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3D printed PLGA scaffold with nano-hydroxyapatite carrying linezolid for treatment of infected bone defects
Publication Year: 2024 Source: Biomed Pharmacother PMID: 38320333 DOI: 10.1016/j.biopha.2024.116228
BACKGROUND: Linezolid has been reported to protect against chronic bone and joint infection. In this study, linezolid was loaded into the 3D printed poly (lactic-co-glycolic acid) (PLGA) scaffold with nano-hydroxyapatite (HA) to explore the effect of this composite scaffold on infected bone defect (IBD). METHODS: PLGA scaffolds were produced using …
Modified DeeplabV3+ with multi-level context attention mechanism for colonoscopy polyp segmentation
Publication Year: 2024 Source: Comput Biol Med PMID: 38320340
No Abstract
Dilated Internal Iliac Artery Confers a Higher Risk of Endoleak in Iliac Branch Devices in a Single Centre Retrospective Experience
Publication Year: 2024 Source: Eur J Vasc Endovasc Surg PMID: 38320646 DOI: 10.1016/j.ejvs.2024.01.087
OBJECTIVE: Iliac branch devices (IBDs) have shown good results but there is little evidence for the risk of internal iliac artery (IIA) endoleak, so there are no clear recommendations on the maximum diameter it should be. Based on limited evidence, it was hypothesised that an IIA of >/= 11 mm …
Biomarkers for Personalizing IBD Therapy: The Quest Continues
Publication Year: 2024 Source: Clin Gastroenterol Hepatol PMID: 38320679 DOI: 10.1016/j.cgh.2024.01.026
Despite recent advances in the understanding of the pathogenesis of inflammatory bowel diseases (IBD) and advent of multiple targeted therapies, approximately one-third of patients are primary non-responders to initiated treatment, and half of patients lose response over time. There is currently a lack of available biomarkers that would prognosticate therapeutic …
The learning curve for using intestinal ultrasonography
Publication Year: 2024 Source: Dig Liver Dis PMID: 38320914 DOI: 10.1016/j.dld.2024.01.192
BACKGROUND AND AIMS: Intestinal ultrasonography (IUS) is challenging to learn. This prospective study examined how the accuracy of IUS increases with operator experience ("learning curve") and if prior abdominal ultrasound experience facilitates the learning process. METHODS: The study included two trainees with limited abdominal ultrasound experience (< 50 exams) and …
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation
Publication Year: 2024 Source: Trends Mol Med PMID: 38320941 DOI: 10.1016/j.molmed.2024.01.001
The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its impairment contributes to the pathogenesis of inflammatory bowel disease (IBD), a chronic inflammatory condition affecting more than seven million people worldwide. Current treatment options specifically …
Effect of huankuile on colon injury in rats with ulcerative colitis by reducing TNF-α and MMP9
Publication Year: 2024 Source: Eur J Med Res PMID: 38321559
No Abstract
High prevalence of muscle weakness and probable sarcopenia in patients with inflammatory bowel disease
Publication Year: 2024 Source: Nutr Clin Pract PMID: 38321633 DOI: 10.1002/ncp.11125
BACKGROUND: This study aimed to determine the prevalence of probable sarcopenia and sarcopenia in patients with inflammatory bowel disease (IBD) by using the European Working Group on Sarcopenia in Older People (EWGSOP2) diagnostic criteria. METHODS: Sarcopenia was assessed by using the sequential four-step algorithm. (1) Find: Sarcopenia risk by simple …
Clinical use of biologics for Crohn's disease in adults: lessons learned from real-world studies
Publication Year: 2024 Source: Expert Opin Biol Ther PMID: 38321868
No Abstract
Exploring the Interconnections of Functional Gut Disorders and Inflammatory Bowel Disease: A Narrative Review Article
Publication Year: 2024 Source: Cureus PMID: 38322093 DOI: 10.7759/cureus.53699
This review reveals details of the interaction between disorders of gut-brain interaction (DGBI) and inflammatory bowel disease (IBD) by providing an in-depth review of that relationship. The review provides a nuanced understanding of this multifaceted dynamic by spanning shared symptomatology, the impact of inflammation on functional aspects, and addressing diagnostic …
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