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Hafnium hydride Nanosheets with reactive oxygen and nitrogen species and cell-free DNA-dual scavenging capabilities for inflammatory bowel disease treatment
Publication Year: 2025 Source: J Colloid Interface Sci PMID: 40544617 DOI: 10.1016/j.jcis.2025.138222
Inflammatory bowel disease (IBD), a chronic inflammatory gastrointestinal disease, is closely related to diverse inflammatory factors like reactive oxygen and nitrogen species (RONS) and cell-free DNA (cfDNA). Herein, tannic acid (TA) modified hafnium hydride nanosheets (HfH(1.983)@TA NSs) with a thickness of 1-4 nm, prepared by liquid-phase exfoliation, were explored as …
Hydrogel loaded with mesalazine for local injected treatment of periodontitis with superior anti-inflammatory, mucosal healing and bone repair performance
Publication Year: 2025 Source: Colloids Surf B Biointerfaces PMID: 40544687 DOI: 10.1016/j.colsurfb.2025.114881
No Abstract
In vitro anti-inflammatory properties of twelve Norwegian medicinal plants
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40544978
ETHNOPHARMACOLOGICAL RELEVANCE: Today, inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease represent a major health burden in Western societies. Such diseases are treated with drugs aiming at suppressing inflammatory symptoms. In Norway, several medicinal plants share a history of ethnomedical use towards the treatment of various inflammatory conditions …
Nuclear adenomatous polyposis coli elevates STAT1 and reduces CXCL1,2, and 3 expression and inhibits neutrophil recruitment
Publication Year: 2025 Source: Cell Signal PMID: 40545113
Adenomatous polyposis coli (APC) mutations and chronic inflammation can each promote colon cancer. Though both mice and humans with germline APC mutations show reduced tumorigenesis if treated with anti-inflammatory agents, direct links between APC and inflammation remain incomplete. In the current study, we examine a novel role for APC in …
Trpa1 knockout favors colon tumorigenesis in dextran sulfate sodium (DSS)-induced colitis mice
Publication Year: 2025 Source: Drug Discov Ther PMID: 40545349
Chronic inflammation in the colon has been recognized as a key pathogenic mechanism driving colorectal cancer development. TRPA1 (transient receptor potential ankyrin 1), a key member of the TRP cation channel superfamily, is closely implicated in inflammatory processes and has emerged as a promising therapeutic target for anti-inflammatory drug development. …
"Vascular complications in inflammatory bowel disease: Moving from recognition to personalised prevention"
Publication Year: 2025 Source: Dig Liver Dis PMID: 40545386
No Abstract
Hyperbaric oxygen therapy for ulcerative colitis patients hospitalized for moderate to severe flares (HBOT-UC): study protocol for a multi-center, randomized, double-blind, sham-controlled trial
Publication Year: 2025 Source: Trials PMID: 40545548
BACKGROUND: Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis. Hyperbaric oxygen therapy involves breathing 100% oxygen under increased atmospheric pressure to increase tissue oxygenation. It reduces systemic and local inflammation and up-regulates hypoxia response pathways, making it an attractive therapeutic option. In this trial we …
Unlocking the power of swine gut bacteria: newly isolated Blautia strain and its metabolites inhibit the replication of Salmonella Typhimurium in macrophages and alleviate DSS-induced colitis in mice
Publication Year: 2025 Source: J Anim Sci Biotechnol PMID: 40545549
BACKGROUND: Inflammatory bowel disease is a significant health concern for both humans and large-scale farm animals. In the quest for effective alternatives to antibiotics, next-generation probiotics (NGPs) have emerged as a promising option. The genus Blautia presents a rich source of potential NGP strains. Here we successfully isolated Blautia hominis …
Evolution of inflammatory bowel disease in Korea: a 60-year perspective on clinical and research development
Publication Year: 2025 Source: Intest Res PMID: 40545620 DOI: 10.5217/ir.2025.00073
Inflammatory bowel disease (IBD) was once considered rare in Korea, with the first reported case documented in 1961. Since then, its incidence and prevalence have increased markedly, accompanied by significant progress in clinical care and research. This narrative review traces the historical evolution of IBD in Korea, dividing the timeline …
A real-world comparison of subcutaneous to intravenous administration of infliximab in patients with inflammatory bowel disease
Publication Year: 2025 Source: Intest Res PMID: 40545621 DOI: 10.5217/ir.2025.00001
BACKGROUND/AIMS: We compared intravenous and subcutaneous infliximab (IFX) as treatment for inflammatory bowel disease (IBD). METHODS: This retrospective, multicenter, observational study enrolled patients treated with either intravenous or subcutaneous IFX. Sequential parameters were compared at baseline, 6 months, and 12 months following the initiation of treatment with either type of …
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