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Impact of Obesity on Treatment Response in Patients With Chronic Inflammatory Disease Receiving Biologic Therapy: Secondary Analysis of the Prospective Multicentre BELIEVE Cohort Study
Publication Year: 2025 Source: Scand J Immunol PMID: 40545788
Biological therapy is used to treat chronic inflammatory diseases (CIDs); however, up to 50% of patients fail to achieve an adequate clinical response. This study aimed to access the impact of obesity on clinical treatment response in CID patients after 14-16 weeks of biological therapy. This multicentre prospective cohort study …
Dendritic Cell-Based Biohybrid Immunomodulator Alleviates Intestinal Inflammatory Disease
Publication Year: 2025 Source: Adv Mater PMID: 40545797 DOI: 10.1002/adma.202420113
Inflammation is a key driver of intestinal inflammatory diseases, such as inflammatory bowel disease (IBD). While biologics have demonstrated notable success in treating some patients, there remains a critical need for alternative therapeutic strategies to address primary and secondary non-responders. In this study, a dendritic cell (DC)-based biohybrid immunomodulator is …
Vedolizumab: Beyond Inflammatory Bowel Disease
Publication Year: 2025 Source: Med Princ Pract PMID: 40545809 DOI: 10.1159/000547015
Vedolizumab (VDZ) is a key therapeutic option for inflammatory bowel disease (IBD) patients, not responding to conventional treatments. An alpha4beta7 integrin antagonist, VDZ primarily prevents T cell migration to the gut by inhibiting the binding of integrins to mucosal vascular address in cellular adhesion molecule. Its gut-selective mechanism of action …
Protective Effects of Human Milk Oligosaccharides (hMOs) on Analgesic, Nonsteroidal Anti-inflammatory Drugs (NSAIDs)-Induced Disruption of Gut Barrier Integrity in Cocultures Mimicking Neuro-Gut Epithelial Cell Crosstalk
Publication Year: 2025 Source: Mol Nutr Food Res PMID: 40545937 DOI: 10.1002/mnfr.70146
Nonsteroidal anti-inflammatory drugs (NSAIDs) like indomethacin alter gut microbiota composition and disrupt intestinal integrity, increasing the risks of inflammatory bowel disease (IBD). Gut barrier function is regulated by a complex crosstalk between different cell types, including epithelial cells and cells from the enteric nervous system (ENS). Human milk oligosaccharides (hMOs), …
Macrophages Internalize Epithelial-Derived Extracellular Vesicles That Contain Ferritin via the Macrophage Scavenger Receptor 1 to Promote Inflammatory Bowel Disease
Publication Year: 2025 Source: J Extracell Vesicles PMID: 40545965 DOI: 10.1002/jev2.70105
The incidence of inflammatory bowel disease (IBD) is on the rise, yet current clinical treatments are limited. Previous studies have identified impairments in both systemic and local iron metabolism in IBD patients. However, the impact of iron dyshomeostasis on the development and pathogenesis of IBD remains elusive. In this study, …
Protective Effect of Resveratrol Against Intracranial Aneurysm Rupture in Mice
Publication Year: 2025 Source: J Neurosci Res PMID: 40546125
Resveratrol is a polyphenol and potent antioxidant that has anti-inflammatory effects in conditions such as atherosclerosis, aortic aneurysm, and inflammatory bowel disease. In this study, we investigated whether resveratrol exerts anti-inflammatory effects and protects against intracranial aneurysm formation and rupture in male mice. Intracranial aneurysms were induced in mice using …
Association Between 10 Autoimmune Diseases and Risk of Pulmonary Tuberculosis: A Mendelian Randomization Study
Publication Year: 2025 Source: J Multidiscip Healthc PMID: 40546289 DOI: 10.2147/JMDH.S516019
BACKGROUND: Pulmonary tuberculosis (PTB) may have an autoimmune component. However, the cause of autoimmune diseases associated with PTB remains unclear. We performed a Mendelian randomization (MR) study to determine the causal genetic connections between liability to autoimmune diseases (AIDs) and PTB. METHODS: After rigorous assessment, potential candidate SNPs for 10 …
Circulating Neutrophil Extracellular Traps as Diagnostic and Prognostic Markers for Inflammatory Bowel Disease: A Case-Control Study
Publication Year: 2025 Source: J Inflamm Res PMID: 40546412 DOI: 10.2147/JIR.S519545
OBJECTIVE: Current challenges in inflammatory bowel disease (IBD) treatment include the invasive nature of endoscopic evaluation, the gold standard for diagnosis, and the limited prognostic value of traditional inflammatory markers such as CRP and IL-6. This study aimed to explore the potential role of neutrophil extracellular traps (NETs) as biomarkers …
Gut Microbiota as a Key Modulator of Chronic Disease: Implications for Diabetes, Autoimmunity, and Cancer
Publication Year: 2025 Source: Cureus PMID: 40546462 DOI: 10.7759/cureus.84687
The gut microbiota (GM) represents an intricate, dynamic, and complex ecosystem. It plays a key role in health and disease. The GM interacts with the host and modulates various physiological functions, including metabolism, immune regulation, and neurological function. This narrative review comprehensively analyses the role of the GM in the …
Gastric Crohn's Disease With Ileocolonic Involvement in a Patient With Chronic Recurrent Multifocal Osteomyelitis: A Rare Case Presentation
Publication Year: 2025 Source: Cureus PMID: 40546487 DOI: 10.7759/cureus.84586
Gastric Crohn's disease is a rare manifestation of Crohn's disease affecting the stomach, unlike its more common forms that primarily affect the ileum and colon. This is a case of an 18-year-old female who was referred to gastroenterology for investigation of iron deficiency anaemia, which was first noted when she …
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