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Microalgae and Bioactive Substances Therein: Unveiling Therapeutic Promise against Inflammatory Bowel Disease
Publication Year: 2025 Source: J Agric Food Chem PMID: 40682559
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), represents a chronic and recurrent inflammatory ailment of the intestines. It strikes a harsh blow to patients' quality of life. Currently, there is a dearth of effective treatments for IBD, which causes patients to endure significant distress. Thus, …
Editorial: JAK to JAK-Navigating Intra-Class JAK Inhibitor Switching in Inflammatory Bowel Disease. Authors' Reply
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40682429
No Abstract
JPEN Journal Club 94. Qualitative systematic reviews
Publication Year: 2025 Source: JPEN J Parenter Enteral Nutr PMID: 40682300
No Abstract
FXR acts as a therapeutic target for ulcerative colitis via suppressing ferroptosis
Publication Year: 2025 Source: Mol Med PMID: 40681992
BACKGROUND: The involvement of ferroptosis in ulcerative colitis (UC) is increasingly acknowledged. Several investigations have revealed the various mechanisms by which the farnesoid X receptor (FXR) inhibits ferroptosis in certain diseases; however, its potential modulation of ferroptosis in UC remains unexplored. METHODS: The characteristics of FXR expression in colitis were …
The global burden of inflammatory bowel disease: from 2025 to 2045
Publication Year: 2025 Source: Nat Rev Gastroenterol Hepatol PMID: 40681759
Inflammatory bowel disease (IBD) is a global condition that progresses through four epidemiologic stages: emergence, acceleration in incidence, compounding prevalence and prevalence equilibrium. Early industrialized countries are currently in the compounding prevalence stage before transitioning to the prevalence equilibrium stage, with >1% of their populations expected to live with IBD …
Reflections on youth partnership in a randomized controlled trial of an intervention to optimize transition from pediatric to adult care in inflammatory bowel disease
Publication Year: 2025 Source: Health Care Transit PMID: 40688098
BACKGROUND: Patient engagement allows for developing health interventions and research studies that align with the needs of people living with chronic diseases. Actively involving people with lived experience as partners in the design and governance of interventional trials is gaining prominence. However, there is a dearth of literature exploring the …
Comment On: Predictors of Complicated Disease Course in Children and Adults With Ulcerative Colitis: A Nationwide Study From the epi-IIRN
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40690522
No Abstract
Breaking Conventions: Innovative Reflections on the Medication Use Research of Inflammatory Bowel Disease in Adults and the Elderly
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40690517
No Abstract
Clinical characteristics and long-term outcomes among inflammatory bowel disease patients of different ethnic groups: a case-control study
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 40690326
INTRODUCTION: Inflammatory bowel disease (IBD) causes chronic inflammation in the gastrointestinal tract, particularly in the colon and small intestine. We aimed to compare the clinical characteristics and long-term outcomes of Arab Bedouin and Jewish IBD patients in the Negev. METHODS: This retrospective case-control study (1:2 matching, controlled for age and …
Bidirectional causal links between diabetes mellitus and autoimmune liver diseases: Insights from Mendelian randomization
Publication Year: 2025 Source: J Diabetes Investig PMID: 40689680
BACKGROUND: Diabetes, a growing global public health issue, is often associated with autoimmune liver diseases (AILD), such as autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), in both type 1 diabetes (T1DM) and type 2 diabetes (T2DM). However, the causal relationship between these conditions remains unclear. …
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