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Addressing the Critical Gap in Biological Therapies for Inflammatory Bowel Disease in Syria
Publication Year: 2025 Source: Avicenna J Med PMID: 40546901
No Abstract
Application of single-cell sequencing in the study of immune cell infiltration in inflammatory bowel disease and colorectal cancer
Publication Year: 2025 Source: World J Gastrointest Oncol PMID: 40547160 DOI: 10.4251/wjgo.v17.i6.107382
The rapid advancement of single-cell sequencing (SCS) technology has provided new insights into the relationship between inflammatory bowel disease (IBD) and colorectal cancer (CRC). This technique allows for detailed cellular analysis, enabling researchers to uncover the infiltration patterns of immune cells within the gut microenvironment and their roles in disease …
Discordance between patients' perception and endoscopic assessment of disease activity in ulcerative colitis
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40547250 DOI: 10.1177/17562848251346258
BACKGROUND: Discrepancies between symptoms and endoscopy exist in patients with ulcerative colitis (UC). Most studies focused on patient-reported outcomes-2 rather than their overall perception of disease activity. OBJECTIVES: The objectives were to assess the concordance between the patient global assessment (PtGA) and the endoscopic evaluation, to analyse the factors associated …
Successful treatment of refractory pyoderma gangrenosum with risankizumab in a 57-year-old patient: A case report
Publication Year: 2025 Source: SAGE Open Med Case Rep PMID: 40547405
Pyoderma gangrenosum is a neutrophilic dermatosis characterized by rapidly progressing inflammatory skin lesions. It is often associated with underlying systemic conditions, such as inflammatory bowel disease and rheumatoid arthritis. Patients typically present with erythematous papules and pustules that rapidly evolve into painful ulcers, most commonly affecting the lower extremities. In …
Long-term outcome in Wiskott-Aldrich syndrome and X-linked thrombocytopenia patients: an observational -prospective multi-center study of the Italian Primary Immune Deficiency Network (IPINET)
Publication Year: 2025 Source: EClinicalMedicine PMID: 40547444
BACKGROUND: Wiskott-Aldrich Syndrome (WAS) is characterized by eczema, infections, and severe bleeding, but may also include autoimmunity and malignancy. Subjects with X-linked thrombocytopenia (XLT) can display a mild phenotype, although severe complications may occur at any age. WAS and XLT are caused by mutations of the WAS gene. However, retrospective …
Alchemizing earth's legacy: Bismuth-engineered humic nanoparticles for IBD theranostics through mitochondrial anti-inflammation and sustained intestinal delivery
Publication Year: 2025 Source: Mater Today Bio PMID: 40547490 DOI: 10.1016/j.mtbio.2025.101948
Humic acid (HA), a complex organic substance naturally present in soil, peat, and coal, is traditionally referred to as the extract of "Wujinshi" () in Chinese medicine. It is renowned for its potent anti-inflammatory, analgesic, and blood circulation-promoting properties. However, its mechanisms and delivery methods require further exploration. We developed …
The Roles of Dietary Bioactive Compounds in Alleviating Inflammatory Bowel Disease-Associated Colorectal Cancer
Publication Year: 2025 Source: Food Sci Nutr PMID: 40548181 DOI: 10.1002/fsn3.70432
Inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) is a serious global health issue. Owing to the successful mimicking of the entire process of CRC induced by IBD, azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced colitis-associated cancer (CAC) animal models have been widely used to study the carcinogenic mechanisms of IBD-associated …
Gut virome: New key players in the pathogenesis of inflammatory bowel disease
Publication Year: 2025 Source: World J Methodol PMID: 40548227 DOI: 10.5662/wjm.v15.i2.92592
Inflammatory bowel disease (IBD) is a chronic inflammatory illness of the intestine. While the mechanism underlying the pathogenesis of IBD is not fully understood, it is believed that a complex combination of host immunological response, environmental exposure, particularly the gut microbiota, and genetic susceptibility represents the major determinants. The gut …
Clinical Utility and Cost-Effectiveness of Pretreatment NUDT15 Pharmacogenetic Testing to Prevent Thiopurine-Induced Myelosuppression: A Genotype-First Reverse Phenotyping Cohort Study Within the UK NIHR Inflammatory Bowel Disease Bioresource
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40548539
BACKGROUND: The clinical utility and cost-effectiveness of pre-thiopurine NUDT15 pharmacogenetic testing in European and admixed populations are unknown. AIMS: To report the prevalence, penetrance, expressivity, and pathogenicity of NUDT15 variant allele carriage and the diagnostic accuracy and cost-effectiveness of an inexpensive loop-mediated isothermal amplification (LAMP) test. METHODS: Retrospective case-matched cohort …
How lived experiences of illness trajectories, burdens of treatment, and social inequalities shape service user and caregiver participation in health and social care: a theory-informed qualitative evidence synthesis
Publication Year: 2025 Source: Health Soc Care Deliv Res PMID: 40548558
BACKGROUND: The workload service users and caregivers take on, and their capacity to do this work, when they engage with and participate in different kinds of care is important. It is reflected in policy and practice interventions that identify service users and caregivers as part of a team that consists …
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