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TMAO and the gut microbiome: implications for the CVD-CKD-IBD axis
Publication Year: 2025 Source: Ann Med PMID: 40548623 DOI: 10.1080/07853890.2025.2522324
Trimethylamine N-oxide (TMAO) is a metabolite produced by the gut microbiome from dietary nutrients such as choline and carnitine. Recent research has found that TMAO is strongly associated with cardiovascular disease (CVD), chronic kidney disease (CKD) and, more recently, inflammatory bowel disease (IBD). Although TMAO is linked to conditions characterized …
[Pyoderma gangrenosum: pathogenesis, diagnosis, and treatment]
Publication Year: 2025 Source: Dermatologie (Heidelb) PMID: 40549162
Pyoderma gangrenosum (PG) is a skin disease that rapidly develops from papules or primarily sterile pustules. It is characterized by the formation of extremely painful wounds with a reddish-livid edge and surrounding areas. It can be triggered by trauma, bacteria or drugs in genetically predisposed people. In 70% of cases, …
Adding Fat to the Fire: Does Lipidated IL-22 Promote Mucosal Healing in Patients with Inflammatory Bowel Disease Treated with Immunomodulators?
Publication Year: 2025 Source: Dig Dis Sci PMID: 40549241
No Abstract
Dysregulation and gene polymorphisms of Vitamin D receptor: its implications in lipid metabolic disorders
Publication Year: 2025 Source: Mol Biol Rep PMID: 40549261
The intricate relationship between vitamin D and metabolic homeostasis has garnered substantial attention recently. The presence of the vitamin D receptor (VDR) in many tissues provides evidence of its broad physiological roles, in addition to its impact on calcium and phosphorus metabolism. VDR gene is expressed in various tissues such …
Epidemiology and Steroid Dependency Reduction in Crohn's Disease During the Biologics Era: A Nationwide Population-Based Study
Publication Year: 2025 Source: Adv Ther PMID: 40549269
INTRODUCTION: Crohn's disease (CD), a subtype of inflammatory bowel disease, is a growing health concern. In this study, we examined the influence of biologics on prescription trends and steroid dependency. METHODS: This retrospective longitudinal analysis of insurance coverage spanned at least 1 year before and 1 year after the inflammatory …
Anti-colitic effects of Oldenlandia umbellata L. through NF-κB pathway inhibition in a DSS-induced mouse model
Publication Year: 2025 Source: Inflammopharmacology PMID: 40549321
BACKGROUND: Ulcerative colitis (UC) is an inflammatory bowel disease marked by epithelial barrier dysfunction and hyperactivation of immune signaling, particularly in the NF-kappaB pathway. Conventional therapies are limited by side effects and relapse risk, highlighting the need for safer, plant-based interventions. Oldenlandia umbellata L., a traditional herb, has demonstrated anti-inflammatory …
Gut microbiome promotes succinate-induced ulcerative colitis by enhancing glycolysis through SUCNR1/NF-κB signaling pathway
Publication Year: 2025 Source: Am J Physiol Cell Physiol PMID: 40549551
Ulcerative colitis (UC) is a chronic recurrent inflammatory disease. Previous studies demonstrate that excessive accumulation of gut microbial metabolites, especially succinate, increases the risk of disease progression. However, the role of succinate and its molecular mechanism have not been explored. We investigated the effects of succinate on colonic inflammation and …
Biological Therapies in Inflammatory Bowel Disease: Predictive Factors of Nonresponse
Publication Year: 2025 Source: J Clin Gastroenterol PMID: 40549632 DOI: 10.1097/MCG.0000000000002179
The treatment modalities for inflammatory bowel disease (IBD) have been rapidly expanding over the past years. Biological therapies are the leading choice of therapy in moderate and severe IBD, aiming to help patients achieve meaningful clinical, endoscopic, and laboratory responses. However, some patients are primary nonresponders and fail to show …
Misdiagnosis of rectal misplaced glands as rectal cancer: A rare case report
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40550026
RATIONALE: We report a rare case of rectal misplaced glands (RMG) with a 2-year disease course. Digital rectal examination identified a semi-circumferential mass approximately 4 cm from the anal verge. Imaging studies revealed irregular thickening of the middle and lower rectal walls with multiple mildly enlarged surrounding lymph nodes. Colonoscopic …
Ulcerative colitis-associated diffuse enteritis without prior colectomy: A case report
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40550068
RATIONALE: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that primarily affects the colon. Although UC is classically limited to the colonic mucosa, rare cases of small bowel involvement have been reported. UC-associated small bowel inflammation is an uncommon complication, most frequently described following colectomy with ileal pouch formation. …
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