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Astragalus membranaceus extract attenuates ulcerative colitis by integrating multiomics and the PI3K/AKT signaling pathway
Publication Year: 2025 Source: Front Pharmacol PMID: 40552164 DOI: 10.3389/fphar.2025.1585748
INTRODUCTION: Ulcerative colitis (UC) is a chronic, non-specific inflammatory bowel disease (IBD) that severely impairs the quality of life of affected individuals. Astragalus membranaceus (Fisch.) Bge. [Fabaceae; Astragali radix] (AM), a widely used Chinese medicine, has active ingredients that exhibit significant anti-inflammatory effects. This study aimed to investigate the role …
Seahorse Attenuated DSS-Induced Depression in Mice by Inhibiting Neuroinflammation and Ferroptosis
Publication Year: 2025 Source: Food Sci Nutr PMID: 40552333 DOI: 10.1002/fsn3.70482
Seahorse (Hippocampus abdominalis), a small fish, has been extensively utilized in traditional Chinese medicine to enhance and harmonize vital energy throughout the body and brain. This study aimed to elucidate the therapeutic role and underlying mechanism of seahorse in treating depressive symptoms. The therapeutic potential of seahorse was investigated in …
Ethanolic Extract of Atractylodis Rhizoma Ameliorates DSS-Induced Ulcerative Colitis via Improving Intestinal Barrier Function Through the Rho-Associated Kinase/Myosin Light Chain Pathway
Publication Year: 2025 Source: J Med Food PMID: 40552462
The utilization of traditional Chinese medicine (TCM) for disease treatment dates back thousands of years. Atractylodis rhizoma (AR) is recognized as a premier TCM and has effective therapeutic properties for gastrointestinal disorders. Nonetheless, the underlying mechanisms by which the ethanolic extract of Atractylodis rhizoma (EEAR) addresses ulcerative colitis (UC) remain …
Fruits, vegetables, legumes and potatoes and risk of Crohn's disease and ulcerative colitis
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40553119
OBJECTIVES: Low intake of fiber, fruits and vegetables is associated with the risk of developing Crohn's disease (CD) and ulcerative colitis (UC). We therefore aimed to assess the risk of developing CD and UC according to individual fruits, vegetables, legumes, and potatoes and their diversity in the European Prospective Investigation …
The Impact of Specialized Pro-Resolving Mediators on Disease Activity and the Risk of Associated Colorectal Carcinoma in Inflammatory Bowel Disease
Publication Year: 2025 Source: Curr Gastroenterol Rep PMID: 40553304 DOI: 10.1007/s11894-025-00997-1
PURPOSE OF REVIEW: The purpose of this review is to explore the role of specialized pro-resolving mediators (SPMs) in the resolution of inflammation in inflammatory bowel disease (IBD) focusing on their potential therapeutic benefits in these conditions. RECENT FINDINGS: IBD is characterized by chronic inflammation and mucosal barrier dysfunction, driven …
Integrative AI-Based Approaches to Connect the Multiome to Use Microbiome-Metabolome Interactive Outcome as Precision Medicine
Publication Year: 2025 Source: Methods Mol Biol PMID: 40553325
In the era of Genome-Wide Association Studies (GWAS), biologists have unprecedented access to vast datasets, mirrored in the wealth of information from various omics studies, including genomics, transcriptomics, proteomics, metabolomics, and metagenomics. Integrating diverse data sources has emerged as crucial in unravelling the intricacies of biological processes. This chapter delves …
Novel Small-Molecule miR-124 Inducer Acts as "a Physiological Brake" of Inflammation in Ulcerative Colitis by Targeting the PIK3R2/PI3K/Akt Axis
Publication Year: 2025 Source: J Med Chem PMID: 40553443
Ulcerative colitis (UC), a chronic inflammatory bowel disease with limited therapeutic options, necessitates novel treatments targeting its complex pathophysiology. This study identified FHND5032, a novel small-molecule miR-124 inducer, as a potent therapeutic candidate for UC. We found that FHND5032 significantly upregulated miR-124 expression in macrophages, surpassing the clinical-stage comparator ABX464 …
A Rare Case of Axial Spondyloarthritis with IgA Vasculitis
Publication Year: 2025 Source: J Assoc Physicians India PMID: 40553537
Spondyloarthritis (SpA) is a chronic inflammatory disease characterized by axial, peripheral, and extra-musculoskeletal manifestations. Axial involvement manifests as sacroiliitis, spondylitis, and peripheral involvement in the form of arthritis, enthesitis, and dactylitis. The extra-musculoskeletal manifestations commonly include uveitis, inflammatory bowel disease, and psoriasis, in addition to rare manifestations such as aortitis, …
Differential Outcomes of Early Versus Late Anti-TNF Therapy in Ulcerative Colitis and Crohn's Disease: A Nationwide Propensity Score-Matched Cohort Study
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40553684 DOI: 10.1002/ueg2.70071
BACKGROUND: Early advanced inflammatory bowel disease (IBD) therapy is emphasised to prevent disease progression and restore quality of life. AIMS: To evaluate the potential advantages of early versus late anti-tumour necrosis factor (TNF) therapy in patients with IBD. METHODS: This retrospective study included patients with newly diagnosed IBD (2004-2018) who …
Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn's Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial
Publication Year: 2025 Source: Gastroenterology PMID: 40553742
BACKGROUND & AIMS: Tasty&Healthy (T&H) is a whole food diet for Crohn's disease (CD) that excludes processed food, gluten, red meat, and dairy, without requiring formula or mandatory ingredients. TASTI-MM was a clinician-blinded, randomized controlled trial comparing tolerability and effectiveness of T&H vs exclusive enteral nutrition (EEN). METHODS: Patients with …
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