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Advancing multispectral optoacoustic tomography (MSOT): Phasor analysis for real-time spectral unmixing
Publication Year: 2025 Source: Comput Biol Med PMID: 40554059
BACKGROUND: Multispectral optoacoustic tomography (MSOT) merges optical and ultrasound imaging to generate high-resolution, molecularly specific images. By capturing ultrasound emissions at multiple wavelengths, MSOT enables real-time visualization of tissue slices or volumes. The technique's specificity relies on chromophores emitting distinct signals across different wavelengths, requiring accurate spectral unmixing. However, existing …
Enhanced anti-inflammatory efficacy of a new piroxicam analogue through the MEK/ERK/NF-κB pathway in vitro and in vivo
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40554258 DOI: 10.1016/j.intimp.2025.115100
Piroxicam (PX) is potent and widely used for the treatment of inflammatory conditions. To develop active PX analogues with improved anti-inflammatory activity and minimized adverse effects, a series of PX analogues were designed and synthesized for enhancing anti-inflammatory activity. Among these derivatives, compound 12 exhibited superior NO-inhibitory ability with minimal …
The Role of Novel Small Molecule Drugs in the Management of Inflammatory Bowel Disease
Publication Year: 2025 Source: Br J Hosp Med (Lond) PMID: 40554447 DOI: 10.12968/hmed.2024.0798
Treatment algorithms have traditionally been based on biological therapy when conventional therapy was not successful in controlling inflammatory bowel disease (IBD). Novel small molecule drugs (SMDs) for IBD include the Janus Kinase (JAK) inhibitors Tofacitinib, Filgotinib and Upadactinib and the sphingosine-1 phosphate (S1P) inhibitors Ozanimod and Etrasimod. SMDs have advantages …
Real-World Clinical Effectiveness and Safety of Vedolizumab and Ustekinumab in Biologic-Naive Patients With Crohn's Disease By Disease Location: Results from the EVOLVE Expansion Study
Publication Year: 2025 Source: J Clin Gastroenterol PMID: 40554515 DOI: 10.1097/MCG.0000000000002186
GOALS: This analysis compared the real-world effectiveness and safety of vedolizumab versus ustekinumab in biologic-naive patients by CD location. BACKGROUND: Crohn's disease (CD) location may affect disease course and treatment decisions. STUDY: Medical charts of biologic-naive patients with CD aged 18 years or older initiating vedolizumab or ustekinumab were analyzed …
Natural History, Treatment Persistence and Predictors of Treatment Failure in Patients With Ulcerative Colitis on 5-Aminosalicylic Acid: A US Population-Level Cohort Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40554593
INTRODUCTION: Limited data exist on the natural history and treatment persistence in ulcerative colitis (UC) patients on 5-aminosalicylic acid (5-ASA) in the era of biologic agents and small molecules. METHODS: This was a retrospective cohort study utilizing the US Collaborative Network in patients with UC who were initiated on 5-ASA …
The Dual Role of ACE2 in IBD: Balancing SARS-CoV-2 Susceptibility and Gut Homeostasis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40554594 DOI: 10.1093/ibd/izaf132
No Abstract
Inflammation of the Rectal Cuff is Associated With Strictures and Fistulas in Patients With Ulcerative Colitis who Have an Ileal Pouch-Anal Anastomosis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40554598
BACKGROUND: Patients with medically refractory ulcerative colitis (UC) may undergo colectomy with ileal pouch-anal anastomosis (IPAA). Rectal cuff inflammation following surgery is common and may be associated with pouch failure, but the mechanisms underlying this association remain unclear. We assessed whether endoscopic cuff inflammation is associated with fistula and stricture …
Genetic disease risks of under-represented founder populations in New York City
Publication Year: 2025 Source: PLoS Genet PMID: 40554605 DOI: 10.1371/journal.pgen.1011755
The detection of founder pathogenic variants, those observed in high frequency only in a group of individuals with increased inter-relatedness, can help improve delivery of health care for that community. We identified 16 groups with shared ancestry, based on genomic segments that are shared through identity by descent (IBD), in …
Correction to "Rewiring Tryptophan Metabolism via Programmable Probiotic Integrated by Dual-Layered Microcapsule Protects against Inflammatory Bowel Disease in Mice"
Publication Year: 2025 Source: ACS Nano PMID: 40554607
No Abstract
Efficacy of Risankizumab Dose Escalation Among Patients With Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40554625
No Abstract
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