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Enterocolic lymphocytic phlebitis: Clinical insights from a literature review
Publication Year: 2025 Source: Med Clin (Barc) PMID: 40555030
OBJECTIVE: Enterocolic lymphocytic phlebitis (ELP) is a rare venous-specific gastrointestinal inflammation with challenging preoperative diagnosis. We aimed to characterize its clinicopathological spectrum. PATIENTS AND METHODS: This narrative review synthesizes evidence from 85 published cases (9-81 years) from 50 articles to characterize ELP's clinicopathological features and diagnostic pitfalls, along with its …
Advanced biologic therapies and cardiovascular events in patients with inflammatory bowel disease
Publication Year: 2025 Source: Am J Prev Cardiol PMID: 40469220 DOI: 10.1016/j.ajpc.2025.100991
AIMS: Atherosclerotic cardiovascular disease (ASCVD) risk is increased in patients with Inflammatory Bowel Disease (IBD). The impact of advanced biologic therapies (ABT) on ASCVD risk in patients with IBD has not been reported. This study tests the hypothesis of a protective effect of immune modulation with ABT on ASCVD risk …
Pharmacogenomics of TNF inhibitors
Publication Year: 2025 Source: Front Immunol PMID: 40469293
Tumor necrosis factor alpha inhibitors (TNFi) are biologic drugs that target TNFalpha, a key pro-inflammatory cytokine, to suppress disease activity and alleviate symptoms of various autoimmune diseases, including inflammatory bowel disease. This review focuses on the five US FDA-approved TNFi including the monoclonal antibodies Infliximab, Adalimumab, Golimumab, Certolizumab pegol and …
Gut microbiota-derived butyrate mediates the anticolitic effect of indigo supplementation through regulating CD4(+) T cell differentiation
Publication Year: 2025 Source: Imeta PMID: 40469515
This study explored the effect of plant-derived indigo supplementation on intestinal inflammation using in vivo, in vitro, and clinical sample analyses. Our results showed that indigo decreased mucosal inflammation by regulating CD4(+) T cell differentiation in a gut microbiota-dependent manner. Microbes transferred from indigo-treated mice, indigo-induced enrichment of Roseburia intestinalis, …
Bibliometric analysis of research on intestinal flora and primary biliary cholangitis published between 2004 and 2024 using VOSviewer and CiteSpace visualization
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40470048
BACKGROUND: Increasing evidence suggests that the onset and progression of primary biliary cholangitis (PBC) are closely linked to changes in gut microbiota, including bacterial translocation, molecular mimicry, and immune regulation. This study aimed to conduct a bibliometric analysis of the frontiers and hotspots of research on the relationship between gut …
Improving Procedural Documentation of Newly Diagnosed Pediatric Inflammatory Bowel Disease Patients: A Single-center Quality Improvement Study
Publication Year: 2025 Source: Pediatr Qual Saf PMID: 40470290 DOI: 10.1097/pq9.0000000000000819
INTRODUCTION: Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn disease (CD), presents significant challenges in management, particularly regarding standardized endoscopic scoring. This study aimed to assess and improve procedural documentation practices among endoscopists managing newly diagnosed pediatric IBD (PIBD). METHODS: This quality improvement project involved a preintervention review of …
Anti-tumor Necrosis Factor-Alpha (TNF-α)-Induced Hypertrophic Lichen Planus: A Case Report
Publication Year: 2025 Source: Cureus PMID: 40470457
We report the case of a 26-year-old male patient with a six-year history of inflammatory bowel disease who developed pruritic, hyperpigmented, and hyperkeratotic nodules on his left abdomen three months after switching from adalimumab to infliximab therapy. Clinical examination and histopathological analysis confirmed the diagnosis of hypertrophic lichen planus (HLP), …
Post-Colonoscopy Perforation in a Patient With Ulcerative Colitis
Publication Year: 2025 Source: Cureus PMID: 40470463
Ulcerative colitis, a chronic inflammatory bowel disease, renders the colonic mucosa particularly vulnerable to complications during endoscopic procedures. This case illustrates a serious complication following colonoscopy in active disease. A 25-year-old female presented with two weeks of hematochezia. Colonoscopy revealed severe active inflammation with ulcerations, friability, and spontaneous bleeding throughout …
Positioning Guselkumab in The Treatment Algorithm of Patients with Crohn's Disease
Publication Year: 2025 Source: Biologics PMID: 40470513 DOI: 10.2147/BTT.S530354
Guselkumab, a selective interleukin-23 (IL-23) inhibitor, has emerged as a promising biologic therapy for the management of patients with moderate-to-severe Crohn's disease (CD) and has been recently approved for its treatment. Unlike conventional therapies, guselkumab offers a different mechanism of action by selectively inhibiting IL-23, a key cytokine implicated in …
A multicenter study on bowel preparation in inflammatory bowel disease patients: comparison between 1L-PEG-ASC and 2L-PEG regimens in an outpatient setting
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 40470699 DOI: 10.1097/MEG.0000000000003005
BACKGROUND AND AIMS: There is a paucity of data on which bowel preparation (BP) to use in an inflammatory bowel disease (IBD) outpatient setting, in particular after the introduction of 1L-PEG-ASC. Thus, we aimed to evaluate the most effective BP between 1L-PEG-ASC and 2L-PEG and to identify risk factors for …
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