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A review of the capacity of xylooligosaccharides to modulate gut microbiota and promote health
Publication Year: 2025 Source: Food Funct PMID: 40470881
Xylooligosaccharides (XOS), derived from lignocellulosic biomass and algae, have emerged as promising prebiotics due to their ability to selectively modulate gut microbiota and confer various health benefits. XOS are composed of beta-D-xylopyranose units linked by beta-glycosidic bonds and are resistant to mammalian digestion but fermentable by beneficial gut bacteria. Research …
Repurposing liraglutide to the management of DSS-induced colitis: a potential for promoting autophagy
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 40471244 DOI: 10.1007/s00210-025-04339-w
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that typically requires long-term drug treatment. The emerging role of glucagon-like peptide 1 (GLP-1) and its receptor agonists in gastrointestinal diseases has drawn much attention. A mouse model of acute colitis was conducted using a 7-day protocol of dextran sulfate …
Preoperative immunosuppressive therapy might not affect the length of resected bowel in patients receiving ileocolic resection for Crohn's disease
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 40471309
PURPOSE: Rates of surgery remain relevant for localized Crohn's disease despite the evolution of novel therapies. However, the effect of immunosuppressive medication on the perioperative outcome including the extent of the resection is still inconclusive and needs to be evaluated. METHODS: In a single-center study, all patients who received ileocolic …
Curbing Communication - Transanal Infiltration of Autologous Mesenchymal Stem Cells Facilitating Rectovesical Fistula Repair After Radical Prostatectomy
Publication Year: 2025 Source: Dig Dis Sci PMID: 40471497
Treatment of acquired rectovesical or rectourethral fistula can be very challenging for surgeons. When a conservative approach fails, complex surgery is needed, with a substantial probability of complications and recurrences. In order to minimize the need for major surgery, autologous mesenchymal stem cells have been used to treat fistulas, especially …
Effectiveness and Safety of Advanced Combination Treatment (ACT) in patients with refractory inflammatory bowel disease or concomitant immune mediated disease or extra-intestinal manifestations: A Multi-Center Canadian Study
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40471825 DOI: 10.14309/ajg.0000000000003573
INTRODUCTION: Due to the therapeutic ceiling associated with inflammatory bowel disease (IBD) therapies, some patients may require two advanced therapeutic agents, known as advanced combination treatment (ACT) to control disease or treat associated extraintestinal manifestations (EIMs). METHODS: We included adult IBD patients from 9 Canadian centers treated with either two …
CCR2 overexpressing gingiva mesenchymal stem cells provide high intestinal regeneration in a rat model of ulcerative colitis
Publication Year: 2025 Source: PLoS One PMID: 40472038
BACKGROUND/AIMS: Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colon. Mesenchymal stem cells (MSCs) are candidates for use in inflammatory diseases with their tissue regeneration and anti-inflammatory capabilities. Chemokine receptor overexpression on MSCs is an effective strategy for the migration of MSCs into inflammatory tissue in high amounts. …
Design and synthesis of novel xanthone-thiazole hybrid derivatives as potent anti-inflammatory agent
Publication Year: 2025 Source: Comput Biol Chem PMID: 40472622
Inflammation is a crucial physiological process that, when dysregulated can lead to chronic diseases such as arthritis, asthma and inflammatory bowel disease. This study focused on the design, synthesis and evaluation of novel xanthone-thiazole hybrid derivatives as potential anti-inflammatory agents using a straightforward experimental procedure. Anti-inflammatory activity was assessed through …
Co-designing a new body image and wellbeing intervention for Australians with inflammatory bowel disease
Publication Year: 2025 Source: Body Image PMID: 40472652 DOI: 10.1016/j.bodyim.2025.101916
Individuals with inflammatory bowel disease (IBD) often present with high body dissatisfaction, poorer quality of life and comorbid psychiatric conditions including eating disorders, anxiety, and depression. The aim of this study was to co-design a new intervention to support people with IBD and body image concerns. To the best of …
In vitro activity, structural characterization and modulation of DSS-induced intestinal inflammation in zebrafish by Pseudognaphalium affine (D.Don) Anderb polysaccharides
Publication Year: 2025 Source: Fitoterapia PMID: 40472978
A wide range of medicinal values and good health effects characterizes pseudognaphalium affine (D.Don) Anderb. PHP, as a polysaccharide fraction, was isolated and purified from Pseudognaphalium affine (D.Don) Anderb. This study evaluated PHP's structural characteristics in terms of its molecular weight, functional groups, and monosaccharide content. After dextrose sodium sulfate …
Prevalence and Impact of Social Risk in Patients With Inflammatory Bowel Diseases: National Estimates from the United States
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40473090 DOI: 10.1016/j.cgh.2025.03.031
BACKGROUND AND AIMS: Social risks are individual-level factors associated with adverse health outcomes. We determined the prevalence and impact of social risks on healthcare use among patients with inflammatory bowel diseases (IBDs) in the United States. METHODS: In the U.S. National Health Interview Survey 2023, we estimated social risks across …
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