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Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn's disease
Publication Year: 2025 Source: Front Immunol PMID: 40475778 DOI: 10.3389/fimmu.2025.1539830
Despite the increasing incidence of Crohn's disease (CD), its early immune disturbances have not all been described yet. We analysed single-cell RNASeq data from peripheral blood mononuclear cells of patients with incidentally-diagnosed CD, and compared their gene expression profile to healthy individuals. The main aim of our study was to …
The Prevalence of Sarcopenia in Crohn's Disease Patients and Its Correlation With Disease Activity and Effect on Prognosis
Publication Year: 2025 Source: Cureus PMID: 40476129
Introduction Crohn's disease (CD) is a chronic inflammatory disorder that can involve any part from mouth to anus but predominantly involves the distal small intestine and proximal colon. Sarcopenia is recognized as muscle failure consequent to loss of skeletal muscle strength, function, and mass. Sarcopenia was found to be prevalent …
Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis
Publication Year: 2025 Source: Clin Sci (Lond) PMID: 40476597 DOI: 10.1042/CS20256078
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with underlying inflammatory bowel disease (IBD). This study investigates how PSC predisposes individuals to altered inflammatory immune responses compared with IBD alone. A case-control study was conducted with a cohort of 75 patients, including 16 with PSC (14 …
Temporal Trends in Mortality Related to Crohn's Disease in the United States: A 21-year Retrospective Analysis of CDC-WONDER Database
Publication Year: 2025 Source: J Clin Gastroenterol PMID: 40478201
BACKGROUND: Crohn's disease is a chronic and debilitating inflammatory bowel disease that affects many people worldwide. This study explores mortality trends associated with Crohn's disease across various age groups, racial and ethnic backgrounds, urban and suburban settings, and census regions. GOALS: By examining age-adjusted mortality rates (AAMRs), we identified the …
Association of Primary Language with Treatment and Outcomes in Inflammatory Bowel Disease
Publication Year: 2025 Source: Clin Transl Gastroenterol PMID: 40478247 DOI: 10.14309/ctg.0000000000000868
BACKGROUND: As rates of inflammatory bowel disease (IBD) rise among non-English speaking populations, it is imperative to better understand the impact of language barriers and cultural differences on disease management. METHODS: Multi-center, retrospective, cohort study of adult patients with IBD who spoke a language other than English, matched 1:2 to …
Screening and validation of 3'-Methoxydaidzein as a therapeutic agent in ulcerative colitis based on disulfidptosis-associated molecular clusters
Publication Year: 2025 Source: PLoS One PMID: 40478904
BACKGROUND: Ulcerative colitis (UC) is a recurrent inflammatory condition of the bowel with a multifaceted pathogenesis, including programmed cell death, oxidative stress, and immune-mediated inflammation. As a recently identified type of cell death, disulfidptosis has an unclear role in UC. METHODS: We analyzed clusters of disulfidptosis-related genes (DRGs) and immune …
Deep learning reconstruction for T2-weighted and contrast-enhanced T1-weighted magnetic resonance enterography imaging in patients with Crohn's disease: Assessment of image quality and clinical utility
Publication Year: 2025 Source: Clin Imaging PMID: 40479900
PURPOSE: To investigate the image quality of deep learning-reconstructed T2-weighted half-Fourier single-shot turbo spin echo (DL T2 HASTE) and contrast-enhanced T1-weighted volumetric interpolated breath-hold examination (DL T1 VIBE) of magnetic resonance enterography in patients with Crohn's disease. METHODS: Ninety-three patients for the comparison between T2 HASTE and DL T2 HASTE, …
Artemether ameliorates DSS-induced ulcerative colitis by modulating macrophage polarization
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40480007
Ulcerative colitis (UC) is a type of human intestinal disease with limited therapeutic options and a low cure rate. The difficulty in treating UC is partly attributed to its complex immune regulatory mechanisms. Artemether, a derivatives of artemisinin, has shown significant therapeutic potential in treating immune-related diseases, such as systemic …
The triple association of sickle cell disease, primary sclerosing cholangitis and inflammatory bowel disease (SCD-PSC-IBD): iceberg in sight
Publication Year: 2025 Source: Clin Res Hepatol Gastroenterol PMID: 40480408 DOI: 10.1016/j.clinre.2025.102633
No Abstract
Acetic acid induced-ulcerative colitis is repressed by morin via modulation of CD3/CD4 mucosal immunity and TLR4/NF-κB/ERK1/2/IL-6 signalling in rats
Publication Year: 2025 Source: Food Chem Toxicol PMID: 40480415
Ulcerative colitis (UC) is an inflammatory bowel disease with indefinite etiology. Currently, immune alterations and their consequences are reported to exist beyond UC development. Herein, the potential coloprotective impact of 6 days-administration of two doses of morin (100, 200 mg/kg) was evaluated and compared to dexamethasone against acetic acid-induced ulcerative …
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