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Arabinoxylan from barley bran alleviates ulcerative colitis in mice through enhancement of mucosal barrier function and modulation of gut microbiota
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40480573
Recurrent and intractable colitis is very distressing for patients. Natural dietary fibers and polysaccharides have shown great potential in the prevention and management of Inflammatory bowel disease. This study aimed to investigate the ameliorative effects of arabinoxylan (AX), derived from barley bran, on dextran sulfate sodium induced ulcerative colitis in …
Optimal positioning of biomarkers according to ulcerative colitis activity
Publication Year: 2025 Source: Sci Rep PMID: 40481096
The diagnostic performance and clinical utility of fecal calprotectin (FC), fecal immunochemical occult blood test (FIT), leucine-rich alpha-2 glycoprotein (LRG), C-reactive protein (CRP), and prostaglandin E-major urinary metabolite (PGE-MUM) as established biomarkers for ulcerative colitis (UC) were evaluated. Significant correlations were observed between the clinical activity index, Mayo endoscopic subscore …
Tumor necrosis factor α inhibitor-induced alopecia in pediatric patients: a cohort of 20 patients and review of the literature
Publication Year: 2025 Source: Arch Dermatol Res PMID: 40481366
Anti TNFalpha agents can induce cutaneous adverse events in both adults and children. While drug-related alopecia was reported in adults treated with TNFalpha inhibitors for various indications, pediatric data are scarce. To describe clinical characteristics and outcomes in pediatric patients with TNFalpha inhibitor-induced alopecia we conducted a single center retrospective …
Factors Impacting the Immunogenicity of Etrolizumab & Clinical Consequences
Publication Year: 2025 Source: AAPS J PMID: 40481373 DOI: 10.1208/s12248-025-01090-1
Ulcerative colitis (UC) and Crohn's disease (CD), pose a substantial burden, necessitating effective therapies. Etrolizumab, a unique monoclonal antibody targeting integrins, initially showed promise but was terminated due to lack of efficacy in PhIII studies. The immune responses elicited by patients towards etrolizumab make it a compelling subject for further …
Treatment sequences, outcomes, healthcare utilization, and costs in patients with inflammatory bowel diseases requiring advanced treatment-real world comparative effectiveness from German claims data
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40481399
BACKGROUND: There is limited data on inflammatory bowel disease advanced therapy sequences. Therefore, we examined real-world advanced therapy sequences to compare persistence, healthcare use and costs in first-line advanced therapy. METHODS: Evaluable patient characteristics, treatments, sequences, and outcomes were extracted from the WIG2 claims benchmark database and observed from 2014 …
Lactobacillus plantarum-derived extracellular vesicles from dietary barley leaf supplementation attenuate Citrobacter rodentium infection and intestinal inflammation
Publication Year: 2025 Source: J Nanobiotechnology PMID: 40481571 DOI: 10.1186/s12951-025-03504-w
BACKGROUND: Inflammatory bowel disease (IBD) is a gastrointestinal inflammatory disorder characterized by disturbed interactions between gut microbiota and host immune response. Barley leaf (BL) is a traditional Chinese herb recorded to have health-promoting effects. However, little is known about the beneficial role of BL against enteric infection-induced intestinal inflammation. Here, …
Outcomes Associated With Anti-Depressant Use in Patients With Inflammatory Bowel Disease
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40481682 DOI: 10.1111/apt.70229
BACKGROUND: Although depression is prevalent among people with inflammatory bowel diseases (IBD), the impact of treating depression is unknown. METHODS: We conducted a retrospective study in an electronic-health record-based cohort. We identified patients with IBD using >/= 2 diagnosis codes, and patients with depression using >/= 1 diagnosis code. The …
Menstrual Blood‑Derived Endometrial Stem Cells Protect the Integrity of the Intestinal Barrier by Inhibiting the NF-κB/Snail Signaling Pathway
Publication Year: 2025 Source: Cell Biol Int PMID: 40481716 DOI: 10.1002/cbin.70040
Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC) are chronic recurrent nonspecific intestinal disease. Current IBD therapeutics cannot fundamentally change the natural course of IBD. Therefore, it is of great significance to find new treatment strategies for IBD. Preclinical and clinical studies have shown that mesenchymal …
Prevalence and risk factors of renal involvement in seronegative spondyloarthropathies: a systematic review
Publication Year: 2025 Source: Rheumatol Int PMID: 40481867
Seronegative spondyloarthritis (SpA) comprises a heterogeneous group of rheumatic diseases characterized by axial and peripheral joint involvement, as well as extra-articular manifestations, including uveitis, psoriasis, and inflammatory bowel disease. Although renal involvement in SpA is less understood, evidence suggests it may result from disease activity, chronic inflammation, or therapeutic agents. …
Quantified motility assessment in paediatric inflammatory bowel disease: a multi-reader study
Publication Year: 2025 Source: Pediatr Radiol PMID: 40481880
BACKGROUND: Quantitative bowel motility in inflammatory bowel disease using magnetic resonance enterography (MRE) shows promise as a biomarker of disease activity against histopathological and biochemical markers of inflammation when used by experienced readers in a research setting. OBJECTIVE: The aim of this study was to test multi-reader agreement in quantified …
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