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Serum proteins and faecal microbiota as potential biomarkers in newly diagnosed, treatment-naïve inflammatory bowel disease and irritable bowel syndrome patients
Publication Year: 2025 Source: J Mol Med (Berl) PMID: 40481885 DOI: 10.1007/s00109-025-02558-5
Molecular biomarkers are valuable tools to predict the disease and determine its course. Several markers have been associated with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS); however, none is sufficiently reliable to enable accurate diagnosis. We characterized a broad panel of serum proteins to assess disease-specific biomarker profiles …
Indicators for early surgery in patients with intra-abdominal fistulizing Crohn's disease
Publication Year: 2025 Source: Ann Saudi Med PMID: 40482192
BACKGROUND: The management of intra-abdominal fistulizing Crohn's disease involves surgical resection and biologic therapy. The criteria for choosing one therapy over the other are debated. OBJECTIVES: Identify factors influencing the choice of early surgical intervention over biologic therapy. DESIGN: Retrospective. SETTING: Single center, tertiary training and research hospital. PATIENTS AND …
Fidaxomicin Treatment of Clostridioides difficile Infections and Recurrences in Children and Adolescents: A Retrospective Multicenter Study
Publication Year: 2025 Source: J Pediatr PMID: 40482880
OBJECTIVE: To report the effectiveness and tolerability of treating children with primary and recurrent Clostridioides difficile infection (CDI) with fidaxomicin in a real-world, multicenter cohort. STUDY DESIGN: We performed a multicenter, retrospective, observational study of fidaxomicin treatment for primary or recurrent CDI in children ages 12 months to 18 years …
The functional role of the extracellular matrix in inflammatory bowel disease associated gut fibrosis
Publication Year: 2025 Source: Matrix Biol PMID: 40483004 DOI: 10.1016/j.matbio.2025.05.001
No Abstract
Vascular complications in inflammatory bowel disease: moving from recognition to personalised prevention
Publication Year: 2025 Source: Dig Liver Dis PMID: 40483173
No Abstract
Author's reply: "Prevalence and outcomes of arthritis in pediatric IBD: A study from the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition"
Publication Year: 2025 Source: Dig Liver Dis PMID: 40483174 DOI: 10.1016/j.dld.2025.05.003
No Abstract
Predicting severe inflammatory bowel disease: a risk matrix model based on the IBSEN III inception cohort
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40483585 DOI: 10.1080/00365521.2025.2512591
BACKGROUND AND AIMS: Identifying patients at risk of developing severe inflammatory bowel disease (IBD) can aid treatment decisions. However, predicting disease course remains challenging. We aimed to identify predictive factors associated with severe disease course in the first year after IBD diagnosis. METHODS: Newly diagnosed adult (>/=18 years) patients with …
TNF-α Inhibitor Associated Psoriasis in Rheumatoid Arthritis and Inflammatory Bowel Disease Patients: A Disproportionality Analysis Using the FDA Adverse Event Reporting System
Publication Year: 2025 Source: J Cutan Med Surg PMID: 40483716
No Abstract
Design and discovery of novel cyclic peptides as TSP1-CD36 interaction inhibitors for intestinal fibrosis treatment
Publication Year: 2025 Source: Bioorg Chem PMID: 40483936 DOI: 10.1016/j.bioorg.2025.108667
Intestinal fibrosis is a refractory complication of inflammatory bowel disease (IBD), arising from recurrent intestinal inflammation and excessive wound healing. Repeated strictures can lead to intestinal obstruction, with three-quarters of patients with strictures eventually requiring surgery, which severely impacts their quality of life. Thrombospondin-1 (TSP1) is a matricellular protein that …
An anthocyanins-loaded extracellular vesicles coated with fucoidan nano-delivery system for enhancing dietary defense against inflammation-related colon injury
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40484073
Anthocyanins (ACNs) are water-soluble natural pigments exhibiting multiple physiologically active properties. However, their limited stability and bioavailability restrict their use in functional foods and pharmaceutical field applications. In this study, a FU-MEV-ACNs nano-delivery system was successfully constructed by encapsulating ACNs within milk-derived extracellular vesicles (MEV) via ultrasonication, followed by surface …
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