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Structural elucidation of polysaccharide from fresh Areca catechu L. and its mitigation effect on DSS-induced colitis in mice
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40484100
Ulcerative colitis (UC) is an inflammatory bowel disease and has emerged as a public health challenge worldwide. The present study aimed to isolate polysaccharide from fresh Areca catechu L. (FAP1a) and to investigate its potential mechanism for ameliorating UC symptoms in a mouse model of UC. The results indicated that …
Role of Noninvasive Imaging in the Diagnosis and Management of Patients With Suspected and Established Inflammatory Bowel Disease
Publication Year: 2025 Source: Gastroenterology PMID: 40484139 DOI: 10.1053/j.gastro.2025.06.002
In a treat-to-target era, objective disease assessment in inflammatory bowel disease has become increasingly important. For many years, endoscopy has been generally accepted as the gold standard for evaluating the bowel mucosa, additionally facilitating biopsy. However, noninvasive disease assessment is now increasingly demanded, and cross-sectional imaging techniques, as well as …
Targeting to High-Density Lipoprotein Cholesterol: New Insights for Inflammatory Bowel Disease Treatment
Publication Year: 2025 Source: J Lipid Res PMID: 40484317 DOI: 10.1016/j.jlr.2025.100836
BACKGROUND: The anti-inflammatory and vasoprotective properties of high-density lipoprotein cholesterol (HDL-C) make it best known in cardiovascular disease and sepsis. We aimed to investigate whether interventions that target HDL-C metabolism may be used for the prevention and treatment of inflammatory bowel disease (IBD). METHODS: The relationship between serum lipids and …
Enterococcus faecalis hijacks FABP2 to activate quorum-sensing signals and aggravate Crohn's disease by inducing gut dysbiosis
Publication Year: 2025 Source: Gut PMID: 40484632 DOI: 10.1136/gutjnl-2024-334604
BACKGROUND: Crohn's disease (CD) is a chronic inflammatory disorder characterised by intestinal dysbiosis. While inflammation-induced leakage of host proteins is a known phenomenon in CD, how these proteins affect the gut microbiota and contribute to dysbiosis remains unclear. One hypothesis is that commensal bacteria hijack these proteins, exacerbating inflammation in …
Letter to "Prevalence of Faecal Incontinence in Patients With Inflammatory Bowel Disease: Severity and Its Relationship With Quality of Life"
Publication Year: 2025 Source: J Adv Nurs PMID: 40484736
No Abstract
Author's reply: Claudin-2 immunochemistry in IBD
Publication Year: 2025 Source: Dig Liver Dis PMID: 40484746 DOI: 10.1016/j.dld.2025.05.022
No Abstract
Impact of immediate drug optimization of ustekinumab on medium term targets in Crohn's disease: results from the multicentre retrospective real-life study MUST
Publication Year: 2025 Source: Dig Liver Dis PMID: 40484747
BACKGROUND AND AIM: Whether immediate drug dose intensification is a valuable option to optimize ustekinumab efficacy in Crohn's disease (CD) remains unknown. We compared the one-year efficacy of immediate optimisation of ustekinumab 90 mg to 4-weekly with standard 8-weekly dosing in bio-exposed CD patients. METHODS: All consecutive CD patients starting …
Environmental enteropathy and inflammatory bowel disease are not mutually exclusive
Publication Year: 2025 Source: Dig Liver Dis PMID: 40484748 DOI: 10.1016/j.dld.2025.05.001
BACKGROUND: Environmental enteropathy (EE) is an asymptomatic lesion of the small intestine, likely an adaptive response to environmental noxa, including enteropathogens, leading to recurrent intestinal injury, mucosal inflammation, and microbial translocation. Inflammatory bowel disease (IBD) is increasing in incidence in newly industrialised countries. Given that EE is seen in individuals …
[Ulcerative colitis complicated with type 2 autoimmune pancreatitis: a case report]
Publication Year: 2025 Source: Zhonghua Nei Ke Za Zhi PMID: 40484827
No Abstract
Sphingosine-1-Phosphate Receptor Modulators for the Treatment of Ulcerative Colitis: A Narrative Review Focusing on Safety
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40485195
Ulcerative colitis is a chronic immune-mediated inflammatory disease of the colon that causes considerable morbidity and increases the risk of colorectal cancer. Several targeted therapies have been developed for moderate-to-severe ulcerative colitis, significantly improving its management. Ozanimod and etrasimod, oral small-molecule drugs, are the latest addition. They belong to the …
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