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Editorial: Time to EXIT? When Less Is More in IBD Management
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40485227 DOI: 10.1111/apt.70211
No Abstract
Editorial: Time to EXIT? When Less Is More in IBD Management. Authors' Reply
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40485250 DOI: 10.1111/apt.70230
No Abstract
Double infections in the gastrointestinal mucosal biopsies
Publication Year: 2025 Source: Indian J Pathol Microbiol PMID: 40485477 DOI: 10.4103/ijpm.ijpm_689_24
BACKGROUND AND OBJECTIVES: Gastrointestinal infections are an important cause of morbidity and mortality worldwide. There are a few reports of gastrointestinal double infections in immunocompromised patients. In this study, we retrospectively analyzed double infections identified in gastrointestinal mucosal biopsies in a tertiary care center. MATERIALS AND METHODS: This was a …
Machine Learning of Serum Cytokine and Chemokine Profiles Can Classify Inflammatory Bowel Disease Beyond Clinical Diagnosis
Publication Year: 2025 Source: Gastro Hep Adv PMID: 40486268 DOI: 10.1016/j.gastha.2025.100667
BACKGROUND AND AIMS: The pathophysiology of inflammatory bowel disease (IBD) including ulcerative colitis (UC) and Crohn's disease (CD) remains unclear. While IBD is heterogeneous, most molecular-targeted drugs (MTDs) are effective for both UC and CD. The immunological pathoetiology can be considered to overlap regardless of clinical manifestations. Classifying IBD based …
Duodenal ulcer perforation peritonitis as a cause of acute abdomen in pediatric population: a rare case report and review of literature
Publication Year: 2025 Source: Ann Med Surg (Lond) PMID: 40486608
INTRODUCTION: Acute abdomen in pediatric patients presents diagnostic challenges due to the wide range of potential causes and overlapping clinical features. Duodenal ulcer perforation, though rare, can mimic more common conditions like appendicitis, complicating diagnosis and management. Perforated peptic ulcer disease (PUD) in children, especially without chronic nonsteroidal anti-inflammatory drug …
Development and Initial Use of a New Inflammatory Bowel Disease Clinical Database Integrating Both Eastern and Western Clinical Characteristics
Publication Year: 2025 Source: Chronic Dis Transl Med PMID: 40486950 DOI: 10.1002/cdt3.70000
BACKGROUND: The increasing incidence of inflammatory bowel disease (IBD) presents significant medical and societal challenges. A well-designed IBD database is crucial for both epidemiological studies and clinical management. However, inconsistencies between regional databases hinder cross-institutional and international research, especially between Eastern and Western societies. METHODS: We developed a new IBD …
From variability to stability: Sensitivity of network properties in IBD human gut microbiome studies
Publication Year: 2025 Source: Comput Struct Biotechnol J PMID: 40487195 DOI: 10.1016/j.csbj.2025.05.005
BACKGROUND: The gut microbiome's role in inflammatory bowel disease (IBD) is well-established, but capturing its complexity is challenging. Network analysis offers a valuable approach, but selecting suitable measures is crucial. This study examines the sensitivity of network properties to abundance variations. It evaluates whether these properties reflect the microbiome in …
Guts for Self-Eating: Role of Autophagy in Gastrointestinal Health and Disease
Publication Year: 2025 Source: Gastro Hep Adv PMID: 40487273
Autophagy, a highly conserved cellular degradation pathway promotes cell survival via lysosomal degradation of aberrant cellular proteins and recycling of the nutrients. A variety of human diseases are now linked to defective autophagy and there is ever-growing interest in the application of autophagy in healthy living as well as disease …
Ulcerative Colitis but Not Dextran Sodium Sulfate-Induced Colitis-Associated Microbiota Promotes Early Biomarkers of Colitis in Interleukin-10 -/- Mice
Publication Year: 2025 Source: Gastro Hep Adv PMID: 40487274
BACKGROUND AND AIMS: Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis (UC), are inflammatory gastrointestinal conditions in which the pathogenesis is influenced by immune dysfunction, genetics, and environmental factors. Of the 2 conditions, UC is more prevalent, and there is a positive correlation between bacterial dysbiosis and colitis severity …
A Case of Type 2 Autoimmune Pancreatitis Suggesting Two Potential Disease Activity Markers
Publication Year: 2025 Source: Gastro Hep Adv PMID: 40487281
Autoimmune pancreatitis (AIP) is divided into 2 main subtypes: type 1 AIP (AIP-1) and type 2 AIP (AIP-2). This report describes a young woman diagnosed with AIP-2 using endoscopic ultrasound-guided tissue acquisition. AIP-2 has been reported less frequently than AIP-1 as serologic abnormalities and other organ involvement except for inflammatory …
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