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Impact of Obesity on the Long-Term Outcomes of Advanced Therapies in IBD: A Real-World Study in Taiwan
Publication Year: 2025 Source: J Inflamm Res PMID: 40487282 DOI: 10.2147/JIR.S520446
PURPOSE: Obesity has emerged as a factor influencing outcomes in inflammatory bowel disease (IBD), yet its effect on the persistence of advanced biologic therapies, especially in Asian populations, remains unclear. This study evaluates obesity's impact on clinical outcomes and treatment persistence among Taiwanese IBD patients on advanced biologic therapies. METHODS: …
N4BP3 Activates TLR4-NF-κB Pathway in Inflammatory Bowel Disease by Promoting K48-Linked IκBα Ubiquitination
Publication Year: 2025 Source: J Inflamm Res PMID: 40487287 DOI: 10.2147/JIR.S518155
PURPOSE: N4BP3 is a ubiquitination-related gene that plays a pivotal role in neurology and neoplasia. Studies have demonstrated its essential function in axonal and dendritic branching, promoting hepatocellular carcinoma and breast cancer. Our previous research reveals that N4BP3 enhances inflammatory responses by modulating the NOD2 signaling pathway. It is crucial …
Loss of Adenosine Deaminase Acting on RNA 1 Induces Panoptosis and Immune Response in Ulcerative Colitis Gut Mucosa
Publication Year: 2025 Source: MedComm (2020) PMID: 40487746 DOI: 10.1002/mco2.70212
The gut virome is a complex community that exists in equilibrium with the host. Disruptions of this balance could drive the development of inflammatory diseases, such as inflammatory bowel disease (IBD). RNA editing, particularly A-to-I editing by ADAR1, prevents the excessive immune response to viral double strand (ds) RNA. Failure …
Therapeutic Potential of Polyphenols in Targeting Th17/Treg Balance for Intestinal Barrier Maintenance
Publication Year: 2025 Source: Food Sci Nutr PMID: 40488195 DOI: 10.1002/fsn3.70400
The integrity of the intestinal barrier is essential for overall health. Disruption of tight junction (TJs) proteins negatively affects intestinal barrier function, leading to immune imbalances and causing a variety of pathological conditions that are closely associated with the pathogenesis of multiple diseases. Th17 and Treg cells are two distinct …
Pannexin-1 Aggravates Inflammatory Bowel Disease via Unbalancing Macrophage Polarisation and Triggering Ferroptosis in Mice
Publication Year: 2025 Source: Immunology PMID: 40488292 DOI: 10.1111/imm.13948
Inflammatory bowel disease (IBD) is characterised by chronic inflammation in the gastrointestinal tract resulting from dysregulated immune responses to gut microflora. Intestinal macrophages play important roles in the pathogenesis of IBD. The progression of IBD is often associated with increased M1-like macrophages, whereas M2-like macrophages are linked to tissue repair …
Achievement of long-term treatment goals in upadacitinib-treated patients with moderately to severely active ulcerative colitis: a post hoc analysis of phase 3 trial data
Publication Year: 2025 Source: J Crohns Colitis PMID: 40488552
BACKGROUND AND AIMS: Comprehensive disease control is an important yet elusive treatment goal in ulcerative colitis (UC). We evaluated the effect of upadacitinib induction and maintenance treatment on composite clinical endpoints and normalization of important health-related quality of life (HRQoL) outcomes. METHODS: Data from the U-ACHIEVE and U-ACCOMPLISH trials were …
Addressing sexual health among patients with immune-mediated inflammatory diseases
Publication Year: 2025 Source: Br J Nurs PMID: 40488560
BACKGROUND: Sexual health is fundamental to overall health and wellbeing. When a person has one or more immune-mediated inflammatory diseases (IMIDs), their sexual health may be undermined. AIM: To investigate how intimacy and sexual health were affected in patients with IMIDs and to generate knowledge on their disease-related difficulties and …
Metabolism and response to stress gene signatures reveal ulcerative colitis heterogeneity and identify patients with increased response to therapy
Publication Year: 2025 Source: J Crohns Colitis PMID: 40488582
BACKGROUND AND AIMS: Ulcerative colitis (UC) therapies lead to variable remission and response rates in patients participating in clinical trials, likely due to interindividual target variability, differences in active biological pathways, feedback, and/or resistance mechanisms. Here, we stratified patients into subtypes by characterizing heterogeneity using mucosal biopsy transcriptomics data. METHODS: …
Monitoring Inflammatory Bowel Disease Activity: When, How and Why
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40488637 DOI: 10.14309/ajg.0000000000003582
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, are disorders caused by inflammation in the gastrointestinal tract leading to a wide variety of symptoms. The presence of symptoms may not always correlate with active intestinal inflammation and the lack of symptoms does not always indicate control of inflammation. …
The preventive effect of solubilized sturgeon oil on dextran sulfate sodium-induced ulcerative colitis via inflammation attenuation and intestinal microbiota regulation
Publication Year: 2025 Source: Food Funct PMID: 40488649
Ulcerative colitis (UC), an inflammatory bowel disease, causes inflammation in the colonic mucosa. The pathogenesis of UC is closely linked to abnormalities in the gastrointestinal microbiota and immune response. Current treatments for UC primarily alleviate symptoms but are associated with several drawbacks, particularly with prolonged use. Therefore, there is a …
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