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Cohort profile: Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID:IBD) genetic cohort
Publication Year: 2025 Source: Eur J Epidemiol PMID: 40488802 DOI: 10.1007/s10654-025-01239-4
The Copenhagen Hospital Biobank-chronic inflammatory disease-inflammatory bowel disease (CHB-CID: IBD) cohort contributes to genetic research in inflammatory bowel disease, including Crohn's disease and ulcerative colitis. Of the 327,084 enrolled and genotyped individuals in the cohort, 10,626 have been diagnosed with IBD as of May 2023. The CHB-CID: IBD cohort includes …
The clinical application value of the biomarkers based on autophagy screening in the diagnosis and monitoring of inflammatory bowel disease in pediatric patients
Publication Year: 2025 Source: Eur J Pediatr PMID: 40488902 DOI: 10.1007/s00431-025-06213-6
Inflammatory bowel diseases (IBD) are immune-mediated disorders of children and adults. Autophagy dysfunction has been linked to IBD pathology, and we screened and evaluated the potential biomarkers for pediatric IBD diagnosis and activity evaluation. The autophagy gene expression matrix of IBD samples was obtained via GeneCards and GEO databases. Significant …
Regulating Bacteria-Host Interactions for Disease Intervention by Covalent Conjugation of Bacterial Surface
Publication Year: 2025 Source: Acc Chem Res PMID: 40489653
ConspectusThe interactions between bacteria and in vivo environments are critical for microorganism-host association, which plays essential roles in host immunomodulation and nutrient metabolism. Regulating the interactions of bacteria with various in vivo interfaces can vary microorganism-host relationships, offering a promising approach to intervene immune and/or metabolism disorders. However, the rationale …
Causal mediation of plasma metabolomics in pancreatitis: A Mendelian randomization study
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40489851 DOI: 10.1097/MD.0000000000042557
Pancreatitis frequently leads to hospital stay for digestive system disorders and is in high demand for treatment. To identify possible treatment targets, we utilized Mendelian randomization (MR) to investigate the potential causal effects of metabolites on the outcomes of pancreatitis and examined the intermediary roles of risk factors associated with …
Bibliometric analysis of global research trends on ultrasound in inflammatory bowel disease: A quickly developing field
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40489862 DOI: 10.1097/MD.0000000000042226
The aim of this study was to explore the scientific hotspots related to ultrasound in inflammatory bowel disease (IBD) through bibliometric approaches. The Web of Science Core database was used to identify articles about ultrasound and IBD that were published. We retrieved articles related to ultrasound and IBD from the …
Upadacitinib and vedolizumab combination therapy for the management of refractory ulcerative colitis and Crohn's disease
Publication Year: 2025 Source: Intest Res PMID: 40490017 DOI: 10.5217/ir.2024.00174
BACKGROUND/AIMS: Inflammatory bowel disease (IBD) is characterised by chronic inflammation of the gastrointestinal tract, and encompasses both ulcerative colitis (UC) and Crohn's disease (CD). Refractory disease is common, a combination of advanced drug therapies may be required to obtain maximal efficacy. We describe the use of upadacitinib therapy in combination …
Mathematical study of the spread and blocking in inflammatory bowel disease
Publication Year: 2025 Source: Math Biosci PMID: 40490184 DOI: 10.1016/j.mbs.2025.109481
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with mechanisms that are still partially unclear. Unlike other types of IBD, inflammation in UC is limited to the inner lining of the large intestine and rectum, spreading continuously without breaks between affected areas, creating a uniform pattern of inflammation …
Reply to 'Critical appraisal of the HELIOS study on surveillance in IBD patients'
Publication Year: 2025 Source: Gut PMID: 40490317 DOI: 10.1136/gutjnl-2025-335967
No Abstract
Exosomes in inflammation and cancer: from bench to bedside applications
Publication Year: 2025 Source: Mol Biomed PMID: 40490663
Exosomes, lipid bilayer nanovesicles secreted by nearly all cell types, play pivotal roles in intercellular communication by transferring proteins, nucleic acids, and lipids. This review comprehensively summarizes their multiple functions in inflammation and cancer. In inflammation, exosomes exhibit context-dependent pro- or anti-inflammatory effects: they promote acute responses by delivering cytokines …
Fusion analysis of sMRI-DTI in patients with ulcerative colitis by multimodal CCA + joint ICA and associated neurotransmitter profiles
Publication Year: 2025 Source: BMC Med PMID: 40490731
BACKGROUND: As a chronic inflammatory disease, ulcerative colitis (UC) is characterized by complex etiology and unclear pathological mechanisms. Neuroimaging research plays a pivotal role in improving diagnostic accuracy and guiding treatment decisions, while enhancing our understanding of disease mechanisms. We aimed to explore the possible associations between gray matter volume …
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